{"corpus_id":258789608,"paper_sha":"e6292a45d01610d70f9b8a26273d9a8cfa4989c0","doi":"10.1186/s12933-023-01853-0","arxiv_id":null,"pmid":37210516,"pmcid":"10199476","mag_id":null,"dblp_id":null,"acl_id":null,"title":"Drug-coated balloon-based versus drug-eluting stent-only revascularization in patients with diabetes and multivessel coronary artery disease","year":2023,"publication_date":"2023-05-20","venue":"Cardiovascular Diabetology","journal":{"name":"Cardiovascular Diabetology","pages":null,"volume":"22"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, Non-U.S. Gov't"],"s2_fields_of_study":["Medicine"],"reference_count":32,"citation_count":25,"influential_citation_count":1,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Coronary Artery Disease","mj":true,"qs":[{"q":"diagnostic imaging","mj":false,"ui":"Q000000981"},{"q":"therapy","mj":false,"ui":"Q000628"},{"q":"etiology","mj":false,"ui":"Q000209"}],"ui":"D003324"},{"d":"Drug-Eluting Stents","mj":true,"ui":"D054855"},{"d":"Percutaneous Coronary Intervention","mj":true,"qs":[{"q":"adverse effects","mj":false,"ui":"Q000009"}],"ui":"D062645"},{"d":"Retrospective Studies","mj":false,"ui":"D012189"},{"d":"Treatment Outcome","mj":false,"ui":"D016896"},{"d":"Diabetes Mellitus","mj":true,"qs":[{"q":"diagnosis","mj":false,"ui":"Q000175"},{"q":"etiology","mj":false,"ui":"Q000209"}],"ui":"D003920"}],"chemicals":null,"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://cardiab.biomedcentral.com/counter/pdf/10.1186/s12933-023-01853-0","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/e6292a45d01610d70f9b8a26273d9a8cfa4989c0","s2_open_access_license":"CCBY","s2_open_access_status":"CLOSED","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Background Data on drug-coated balloon (DCB) treatment in the context of diabetes mellitus (DM) and multivessel coronary artery disease (CAD) are limited. We aimed to investigate the clinical impact of DCB-based revascularization on percutaneous coronary intervention (PCI) in patients with DM and multivessel CAD. Methods A total of 254 patients with multivessel disease (104 patients with DM) successfully treated with DCB alone or combined with drug-eluting stent (DES) were retrospectively enrolled (DCB-based group) and compared with 254 propensity-matched patients treated with second-generation DES from the PTRG-DES registry (n = 13,160 patients) (DES-only group). Major adverse cardiovascular events (MACE) comprised cardiac death, myocardial infarction, stroke, stent or target lesion thrombosis, target vessel revascularization, and major bleeding at 2 years. Results The DCB-based group was associated with a reduced risk of MACE in patients with DM (hazard ratio [HR] 0.19, 95% confidence interval [CI] 0.05–0.68, p = 0.003], but not in those without DM (HR 0.52, 95% CI 0.20–1.38, p = 0.167) at the 2-year follow-up. In patients with DM, the risk of cardiac death was lower in the DCB-based group than the DES-only group, but not in those without DM. In both patients with or without DM, the burdens of DES and small DES (less than 2.5 mm) used were lower in the DCB-based group than in the DES-only group. Conclusions In multivessel CAD, the clinical benefit of a DCB-based revascularization strategy appears to be more evident in patients with DM than in those without DM after 2 years of follow-up. (Impact of Drug-Coated Balloon Treatment in De Novo Coronary Lesion; NCT04619277)","claims":[{"public_id":"cl_92ed2e429de777b7d65a44b99e7349a5","status":"active","text":"Cardiac death risk was lower with DCB-based treatment than with DES-only treatment in patients with diabetes, while no such reduction was seen in patients without diabetes.","confidence":0.93,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_92ed2e429de777b7d65a44b99e7349a5"},{"public_id":"cl_76449a394efc88517c96f513c89bde50","status":"active","text":"DCB-based revascularization was associated with a lower 2-year risk of major adverse cardiovascular events in patients with diabetes, but not in patients without diabetes.","confidence":0.98,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous 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years.","confidence":0.91,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_1bae79d35c394e9bb02e195dbf8698de"}],"concepts":[{"public_id":"co_3c38e8a95a437705c98396337aea477e","status":"active","name":"drug-eluting stent-only revascularization","description":"A percutaneous coronary revascularization strategy using second-generation drug-eluting stents without drug-coated balloons.","types":["treatment strategy"],"aliases":["DES-only group","DES-only treatment"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_3c38e8a95a437705c98396337aea477e"},{"public_id":"co_43096f60e3082a344b54eb1295776a31","status":"active","name":"drug-eluting stent burden","description":"The amount or number of drug-eluting stents used during revascularization.","types":["procedural measure"],"aliases":["DES burden"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_43096f60e3082a344b54eb1295776a31"},{"public_id":"co_685866600f52cfc13fb096d715571cbd","status":"active","name":"propensity-matched patients","description":"Patients matched using propensity scores to balance baseline characteristics between treatment groups.","types":["study population"],"aliases":["propensity-matched cohort"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_685866600f52cfc13fb096d715571cbd"},{"public_id":"co_87bfeea90019a1d6fbb8144eb86e9efa","status":"active","name":"drug-coated balloon-based revascularization","description":"A 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