{"corpus_id":259039394,"paper_sha":"460080f81ad97159bb7e463f7e757c8267a9d196","doi":"10.1016/j.lfs.2023.121826","arxiv_id":null,"pmid":37270172,"pmcid":null,"mag_id":null,"dblp_id":null,"acl_id":null,"title":"Docosahexaenoic acid and etanercept could reduce functional and metabolic alterations during collagen-induced arthritis in rats without any synergistic effect.","year":2023,"publication_date":"2023-06-01","venue":"Life Science","journal":{"name":"Life sciences","pages":"\n          121826\n        ","volume":null},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article"],"s2_fields_of_study":["Medicine"],"reference_count":52,"citation_count":4,"influential_citation_count":1,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Rats","mj":false,"ui":"D051381"},{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Etanercept","mj":false,"qs":[{"q":"pharmacology","mj":false,"ui":"Q000494"},{"q":"therapeutic use","mj":false,"ui":"Q000627"}],"ui":"D000068800"},{"d":"Docosahexaenoic Acids","mj":false,"qs":[{"q":"pharmacology","mj":false,"ui":"Q000494"},{"q":"therapeutic use","mj":false,"ui":"Q000627"}],"ui":"D004281"},{"d":"Arthritis, Experimental","mj":true,"qs":[{"q":"drug therapy","mj":false,"ui":"Q000188"},{"q":"pathology","mj":false,"ui":"Q000473"}],"ui":"D001169"},{"d":"Sarcopenia","mj":true,"ui":"D055948"},{"d":"Tumor Necrosis Factor Inhibitors","mj":false,"ui":"D000079424"},{"d":"Arthritis, Rheumatoid","mj":true,"qs":[{"q":"drug therapy","mj":false,"ui":"Q000188"}],"ui":"D001172"},{"d":"Fatty Acids, Omega-3","mj":true,"qs":[{"q":"therapeutic use","mj":false,"ui":"Q000627"}],"ui":"D015525"},{"d":"Inflammation","mj":false,"ui":"D007249"},{"d":"Pain","mj":false,"qs":[{"q":"drug therapy","mj":false,"ui":"Q000188"}],"ui":"D010146"}],"chemicals":[{"n":"Etanercept","ui":"D000068800","reg":"OP401G7OJC"},{"n":"Docosahexaenoic Acids","ui":"D004281","reg":"25167-62-8"},{"n":"Tumor Necrosis Factor Inhibitors","ui":"D000079424","reg":"0"},{"n":"Fatty Acids, Omega-3","ui":"D015525","reg":"0"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://www.sciencedirect.com/science/article/am/pii/S0024320523004605","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/460080f81ad97159bb7e463f7e757c8267a9d196","s2_open_access_license":"publisher-specific-oa","s2_open_access_status":"BRONZE","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"AIMS\nRheumatoid arthritis is an autoimmune disease which induces chronic inflammation and increases the risk for sarcopenia and metabolic abnormalities. Nutritional strategies using omega 3 polyunsaturated fatty acids could be proposed to alleviate inflammation and improve the maintenance of lean mass. Independently, pharmacological agents targeting key molecular regulators of the pathology such as TNF alpha could be proposed, but multiple therapies are frequently necessary increasing the risk for toxicity and adverse effects. The aim of the present study was to explore if the combination of an anti-TNF therapy (Etanercept) with dietary supplementation with omega 3 PUFA could prevent pain and metabolic effects of RA.\n\n\nMATERIALS AND METHODS\nRA was induced using collagen-induced arthritis (CIA) in rats to explore of supplementation with docosahexaenoic acid, treatment with etanercept or their association could alleviate symptoms of RA (pain, dysmobility), sarcopenia and metabolic alterations.\n\n\nKEY FINDINGS\nWe observed that Etanercept had major benefits on pain and RA scoring index. However, DHA could reduce the impact on body composition and metabolic alterations.\n\n\nSIGNIFICANCE\nThis study revealed for the first time that nutritional supplementation with omega 3 fatty acid could reduce some symptoms of rheumatoid arthritis and be an effective preventive treatment in patients who do not need pharmacological therapy, but no sign of synergy with an anti-TNF agent was observed.","claims":[{"public_id":"cl_389e58bb5f35542181f5afea84fcc911","status":"active","text":"Docosahexaenoic acid supplementation reduced the impact on body composition and metabolic alterations in collagen-induced arthritis rats.","confidence":0.9,"contributors":[{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["extraction"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale 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with omega-3 polyunsaturated fatty acids could reduce some symptoms of rheumatoid arthritis and be an effective preventive treatment for patients not requiring pharmacological therapy.","confidence":0.85,"contributors":[{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["extraction"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"},{"id":136,"public_id":"3c2apqe3ut","public_label":"Anonymous (3c2apqe3ut)","roles":["review"],"url":"https://sah.borca.ai/u/3c2apqe3ut"}],"url":"https://sah.borca.ai/claims/cl_509b08fe5370f32eaf0ca7ac7e7b7404"}],"concepts":[{"public_id":"co_03c20b3c0d72d2b5113b2c88aa5893db","status":"active","name":"synergistic effect","description":"The lack of interaction between DHA and etanercept observed in the 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