{"corpus_id":261103398,"paper_sha":"e13f60ce93272651e7b9076ff255eed60f8895a8","doi":"10.1007/s12032-023-02140-4","arxiv_id":null,"pmid":37624423,"pmcid":"10457412","mag_id":null,"dblp_id":null,"acl_id":null,"title":"Metformin as a promising target for DPP4 expression: computational modeling and experimental validation","year":2023,"publication_date":"2023-08-25","venue":"Medical Oncology","journal":{"name":"Medical Oncology (Northwood, London, England)","pages":null,"volume":"40"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article"],"s2_fields_of_study":["Medicine"],"reference_count":36,"citation_count":11,"influential_citation_count":0,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Molecular Docking Simulation","mj":false,"ui":"D062105"},{"d":"Dipeptidyl Peptidase 4","mj":true,"qs":[{"q":"genetics","mj":false,"ui":"Q000235"}],"ui":"D018819"},{"d":"Computer Simulation","mj":false,"ui":"D003198"},{"d":"Clinical Relevance","mj":false,"ui":"D000092522"},{"d":"Metformin","mj":true,"qs":[{"q":"pharmacology","mj":false,"ui":"Q000494"},{"q":"therapeutic use","mj":false,"ui":"Q000627"}],"ui":"D008687"}],"chemicals":[{"n":"Dipeptidyl Peptidase 4","ui":"D018819","reg":"EC 3.4.14.5"},{"n":"Metformin","ui":"D008687","reg":"9100L32L2N"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://link.springer.com/content/pdf/10.1007/s12032-023-02140-4.pdf","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/e13f60ce93272651e7b9076ff255eed60f8895a8","s2_open_access_license":"CCBY","s2_open_access_status":"HYBRID","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Metformin is a regularly prescribed and low-cost generic medication. Metformin has been proposed as a target for Dipeptidyl-peptidase 4 (DPP4) expression in various clinical disorders. We provide insilco investigations on molecular docking and dynamic modeling of metformin and DPP4 potential interactions. Moreover, we conducted bioinformatic studies to highlight the clinical significance of DPP4 expression and mutation in various types of malignancies, as well as the invasion of different immune cells into the tumor microenvironment. We believe the present proposal’s findings have crucial implications for understanding how metformin may confer health advantages by targeting DPP4 expression in malignancies.","claims":[{"public_id":"cl_0ad5e33a6b003e39f0892d0771902a81","status":"active","text":"Bioinformatic analysis highlighted the clinical significance of DPP4 expression and mutation across multiple malignancies and their association with immune-cell invasion of the tumor microenvironment.","confidence":0.91,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_0ad5e33a6b003e39f0892d0771902a81"},{"public_id":"cl_ff8171682414e3b7744878a1a0204976","status":"active","text":"Molecular docking and dynamic modeling were used to investigate potential interactions between metformin and DPP4.","confidence":0.95,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_ff8171682414e3b7744878a1a0204976"},{"public_id":"cl_22a039f182fb1f3fc7e798b19831c54b","status":"active","text":"The findings support metformin as a promising modulator of DPP4 expression in malignancies.","confidence":0.84,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_22a039f182fb1f3fc7e798b19831c54b"}],"concepts":[{"public_id":"co_01a238bed03d8c58402e0f42e975e185","status":"active","name":"tumor microenvironment","description":"The local cellular and molecular environment surrounding a tumor.","types":["biological environment"],"aliases":["TME"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_01a238bed03d8c58402e0f42e975e185"},{"public_id":"co_08adbe44998b41fa4a66e8a144642877","status":"active","name":"bioinformatic studies","description":"Computational analyses of biological data used here to assess clinical associations of DPP4.","types":["computational method"],"aliases":["bioinformatics studies"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_08adbe44998b41fa4a66e8a144642877"},{"public_id":"co_3471c02e2260bfd7214c80eb0c54755b","status":"active","name":"DPP4 expression","description":"The level of DPP4 gene or protein expression in biological samples.","types":["molecular feature"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_3471c02e2260bfd7214c80eb0c54755b"},{"public_id":"co_5e2203a0295a8194d87a0065f6f5a55d","status":"active","name":"immune cells","description":"Cells of the immune system considered in relation to tumor infiltration.","types":["cell type"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_5e2203a0295a8194d87a0065f6f5a55d"},{"public_id":"co_61cf8bedb85f2fc433cf9ecd308260b1","status":"active","name":"metformin","description":"A low-cost generic medication investigated here for its potential interaction with DPP4 and relevance to cancer biology.","types":["drug"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_61cf8bedb85f2fc433cf9ecd308260b1"},{"public_id":"co_80700a15c8584c1f6dfaa22a45e79a81","status":"active","name":"dynamic modeling","description":"A computational approach used to examine the temporal behavior and stability of molecular interactions.","types":["computational method"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_80700a15c8584c1f6dfaa22a45e79a81"},{"public_id":"co_9279e5326080c5b2020616bca355f796","status":"active","name":"malignancies","description":"Cancerous diseases examined for DPP4 expression and mutation patterns.","types":["disease"],"aliases":["cancers"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_9279e5326080c5b2020616bca355f796"},{"public_id":"co_e113b0276d0ee758bc54fd0dfd9c96bc","status":"active","name":"molecular docking","description":"A computational method used to estimate binding interactions between molecules.","types":["computational method"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_e113b0276d0ee758bc54fd0dfd9c96bc"},{"public_id":"co_e6db777cf175688c29ff727546badea2","status":"active","name":"DPP4 mutation","description":"Genetic alterations affecting the DPP4 gene or its product.","types":["genetic feature"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_e6db777cf175688c29ff727546badea2"},{"public_id":"co_fd9da98c9a99242c35d529b72ff2b780","status":"active","name":"DPP4","description":"Dipeptidyl-peptidase 4, a protein targeted in the interaction modeling and expression analysis.","types":["protein","enzyme"],"aliases":["dipeptidyl-peptidase 4"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_fd9da98c9a99242c35d529b72ff2b780"}],"external_ids":{"DOI":"10.1007/s12032-023-02140-4","ArXiv":null,"PubMed":37624423,"PubMedCentral":"10457412","MAG":null,"DBLP":null,"ACL":null},"open_access":{"is_open_access":true,"pdf_url":"https://link.springer.com/content/pdf/10.1007/s12032-023-02140-4.pdf","landing_url":"https://www.semanticscholar.org/paper/e13f60ce93272651e7b9076ff255eed60f8895a8","source":"semantic_scholar","pdf_url_source":"semantic_scholar_open_access_pdf","license":"CCBY","status":"HYBRID","reason":null},"reference_availability":{"status":"available","references_indexed":true,"full_text_available":false,"full_text_source":null,"count_basis":"semantic_scholar_metadata","extraction_status":"not_applicable","reason":null},"source":{"provider":"episteme2","base_corpus":"semantic_scholar_dump","freshness_mode":"unknown","basis":["semantic_scholar_metadata","postgres_metadata"],"limits":["paper metadata is based on indexed upstream scholarly datasets","claims and concepts are available only for extracted papers","absence of claims or concepts means no extracted graph data is available in this response"],"status":"available","degraded":false,"degraded_reasons":[],"diagnostics":{"status":"available","degraded":false,"degraded_reasons":[],"metadata_status":"available","graph_status":"available","abstract_status":"available"},"source_flags":5},"paper_id":631876,"paper_uid":"6eac5c40-7866-41be-9f72-58a34cf8e7d8","canonical_identity":{"paper_id":631876,"paper_uid":"6eac5c40-7866-41be-9f72-58a34cf8e7d8","identity_status":"available","lookup_basis":"semantic_scholar_external_id","compatibility_path":"corpus_id"},"url":"https://sah.borca.ai/papers/261103398"}