{"corpus_id":262438573,"paper_sha":"a43784aca65bb7b03281d15ca0e0863e2beb0ca2","doi":"10.7554/eLife.08649","arxiv_id":null,"pmid":26371552,"pmcid":"4608005","mag_id":2102905759,"dblp_id":null,"acl_id":null,"title":"NOCA-1 functions with γ-tubulin and in parallel to Patronin to assemble non-centrosomal microtubule arrays in C. elegans","year":2015,"publication_date":"2015-09-15","venue":"eLife","journal":{"name":"eLife","pages":null,"volume":"4"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, N.I.H., Extramural"],"s2_fields_of_study":["Biology","Medicine"],"reference_count":70,"citation_count":101,"influential_citation_count":8,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Caenorhabditis elegans","mj":false,"qs":[{"q":"physiology","mj":true,"ui":"Q000502"}],"ui":"D017173"},{"d":"Caenorhabditis elegans Proteins","mj":false,"qs":[{"q":"metabolism","mj":true,"ui":"Q000378"}],"ui":"D029742"},{"d":"Cell Cycle Proteins","mj":false,"qs":[{"q":"metabolism","mj":true,"ui":"Q000378"}],"ui":"D018797"},{"d":"Cytoskeletal Proteins","mj":false,"qs":[{"q":"metabolism","mj":true,"ui":"Q000378"}],"ui":"D003598"},{"d":"Microtubule-Associated Proteins","mj":false,"qs":[{"q":"metabolism","mj":true,"ui":"Q000378"}],"ui":"D008869"},{"d":"Microtubules","mj":false,"qs":[{"q":"metabolism","mj":true,"ui":"Q000378"}],"ui":"D008870"},{"d":"Nuclear Proteins","mj":false,"qs":[{"q":"metabolism","mj":true,"ui":"Q000378"}],"ui":"D009687"},{"d":"Protein Multimerization","mj":true,"ui":"D055503"},{"d":"Tubulin","mj":false,"qs":[{"q":"metabolism","mj":true,"ui":"Q000378"}],"ui":"D014404"}],"chemicals":[{"n":"Caenorhabditis elegans Proteins","ui":"D029742","reg":"0"},{"n":"Cell Cycle Proteins","ui":"D018797","reg":"0"},{"n":"Cytoskeletal Proteins","ui":"D003598","reg":"0"},{"n":"Microtubule-Associated Proteins","ui":"D008869","reg":"0"},{"n":"NOCA-1 protein, C elegans","ui":"C000608701","reg":"0"},{"n":"Nuclear Proteins","ui":"D009687","reg":"0"},{"n":"PTRN-1 protein, C elegans","ui":"C000599463","reg":"0"},{"n":"Tubulin","ui":"D014404","reg":"0"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Non-centrosomal microtubule arrays assemble in differentiated tissues to perform mechanical and transport-based functions. In this study, we identify Caenorhabditis elegans NOCA-1 as a protein with homology to vertebrate ninein. NOCA-1 contributes to the assembly of non-centrosomal microtubule arrays in multiple tissues. In the larval epidermis, NOCA-1 functions redundantly with the minus end protection factor Patronin/PTRN-1 to assemble a circumferential microtubule array essential for worm growth and morphogenesis. Controlled degradation of a γ-tubulin complex subunit in this tissue revealed that γ-tubulin acts with NOCA-1 in parallel to Patronin/PTRN-1. In the germline, NOCA-1 and γ-tubulin co-localize at the cell surface, and inhibiting either leads to a microtubule assembly defect. γ-tubulin targets independently of NOCA-1, but NOCA-1 targeting requires γ-tubulin when a non-essential putatively palmitoylated cysteine is mutated. These results show that NOCA-1 acts with γ-tubulin to assemble non-centrosomal arrays in multiple tissues and highlight functional overlap between the ninein and Patronin protein families. 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