{"corpus_id":267666365,"paper_sha":"aaa48337f32a3faf968d983721f5f11eb4a859b4","doi":"10.1016/j.celrep.2024.113756","arxiv_id":null,"pmid":38358886,"pmcid":null,"mag_id":null,"dblp_id":null,"acl_id":null,"title":"Prefrontal projections modulate recurrent circuitry in the insular cortex to support short-term memory.","year":2024,"publication_date":"2024-02-01","venue":"Cell Reports","journal":{"name":"Cell reports","pages":"\n          113756\n        ","volume":"43 2"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, Non-U.S. Gov't"],"s2_fields_of_study":["Biology","Medicine"],"reference_count":110,"citation_count":3,"influential_citation_count":0,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Mice","mj":false,"ui":"D051379"},{"d":"Insular Cortex","mj":true,"ui":"D000087623"},{"d":"Memory, Short-Term","mj":true,"ui":"D008570"},{"d":"Cytoplasm","mj":false,"ui":"D003593"},{"d":"Neurons","mj":false,"ui":"D009474"},{"d":"Optogenetics","mj":false,"ui":"D062308"}],"chemicals":null,"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://www.cell.com/article/S2211124724000846/pdf","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/aaa48337f32a3faf968d983721f5f11eb4a859b4","s2_open_access_license":"CCBYNCND","s2_open_access_status":"GOLD","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Short-term memory (STM) maintains information during a short delay period. How long-range and local connections interact to support STM encoding remains elusive. Here, we tackle the problem focusing on long-range projections from the medial prefrontal cortex (mPFC) to the anterior agranular insular cortex (aAIC) in head-fixed mice performing an olfactory delayed-response task. Optogenetic and electrophysiological experiments reveal the behavioral importance of the two regions in encoding STM information. Spike-correlogram analysis reveals strong local and cross-region functional coupling (FC) between memory neurons encoding the same information. Optogenetic suppression of mPFC-aAIC projections during the delay period reduces behavioral performance, the proportion of memory neurons, and memory-specific FC within the aAIC, whereas optogenetic excitation enhances all of them. mPFC-aAIC projections also bidirectionally modulate the efficacy of STM-information transfer, measured by the contribution of FC spiking pairs to the memory-coding ability of following neurons. Thus, prefrontal projections modulate insular neurons' functional connectivity and memory-coding ability to support STM.","claims":[{"public_id":"cl_69f11e72010ec8a0f7626ebc416935c4","status":"active","text":"Optogenetic excitation of mPFC-aAIC projections enhances behavioral performance, proportion of memory neurons, and memory-specific functional coupling within the aAIC.","confidence":0.95,"contributors":[{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["extraction"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/claims/cl_69f11e72010ec8a0f7626ebc416935c4"},{"public_id":"cl_55fdaa80ac1abba873680887d1b3b87b","status":"active","text":"Optogenetic suppression 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