{"corpus_id":27608012,"paper_sha":"7f2eef7c6e973171053f13ecf3bde5305a76a89e","doi":"10.1128/AAC.00177-06","arxiv_id":null,"pmid":16870794,"pmcid":"PMC1538683","mag_id":2126630384,"dblp_id":null,"acl_id":null,"title":"In Vitro Interactions between Piperaquine, Dihydroartemisinin, and Other Conventional and Novel Antimalarial Drugs","year":2006,"publication_date":"2006-08-01","venue":"Antimicrobial Agents and Chemotherapy","journal":{"name":"Antimicrobial Agents and Chemotherapy","pages":"2883 - 2885","volume":"50"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle","Study"],"pubmed_pub_types":["Comparative Study","Journal Article","Research Support, Non-U.S. Gov't"],"s2_fields_of_study":["Medicine","Chemistry"],"reference_count":24,"citation_count":28,"influential_citation_count":3,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Antimalarials","mj":false,"qs":[{"q":"pharmacology","mj":true,"ui":"Q000494"}],"ui":"D000962"},{"d":"Artemisinins","mj":false,"qs":[{"q":"pharmacology","mj":true,"ui":"Q000494"}],"ui":"D037621"},{"d":"Drug Combinations","mj":false,"ui":"D004338"},{"d":"Drug Interactions","mj":false,"ui":"D004347"},{"d":"In Vitro Techniques","mj":false,"ui":"D066298"},{"d":"Plasmodium falciparum","mj":false,"qs":[{"q":"drug effects","mj":false,"ui":"Q000187"},{"q":"genetics","mj":false,"ui":"Q000235"},{"q":"growth & development","mj":false,"ui":"Q000254"}],"ui":"D010963"},{"d":"Quinolines","mj":false,"qs":[{"q":"pharmacology","mj":true,"ui":"Q000494"}],"ui":"D011804"},{"d":"Piperazines","mj":false,"ui":"D010879"}],"chemicals":[{"n":"Antimalarials","ui":"D000962","reg":"0"},{"n":"Artemisinins","ui":"D037621","reg":"0"},{"n":"Drug Combinations","ui":"D004338","reg":"0"},{"n":"Quinolines","ui":"D011804","reg":"0"},{"n":"piperaquine","ui":"C034759","reg":"A0HV2Q956Y"},{"n":"Piperazines","ui":"D010879","reg":"0"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"ABSTRACT In an in vitro assessment of antimalarial combinations, dihydroartemisinin (DHA) showed no interaction or was mildly antagonistic when combined with piperaquine, pyronaridine, or naphthoquine. Interactions between 4-aminoquinolines and related drugs were also indifferent/antagonistic. The clinical significance of mildly antagonistic DHA combinations is uncertain but may become important if parasite drug sensitivity declines.","claims":[{"public_id":"cl_991ca2293e52f25f3c33aebadd42fe36","status":"active","text":"Dihydroartemisinin showed no interaction or was mildly antagonistic when combined with piperaquine, pyronaridine, or naphthoquine.","confidence":0.98,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_991ca2293e52f25f3c33aebadd42fe36"},{"public_id":"cl_8b88ec4bc43f991b7ab25dfc52516f14","status":"active","text":"Interactions between 4-aminoquinolines and related drugs were indifferent or antagonistic in the in vitro assessment.","confidence":0.92,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous 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