{"corpus_id":27728831,"paper_sha":"81e2c0ab0d10ad6079d9e60cd60e0f08fcfd44cf","doi":"10.4049/jimmunol.162.5.2467","arxiv_id":null,"pmid":10072484,"pmcid":null,"mag_id":1836129895,"dblp_id":null,"acl_id":null,"title":"Cutting edge: alloimmune responses against major and minor histocompatibility antigens: distinct division kinetics and requirement for CD28 costimulation.","year":1999,"publication_date":"1999-03-01","venue":"Journal of Immunology","journal":{"name":"Journal of immunology","pages":"\n          2467-71\n        ","volume":"162 5"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, Non-U.S. Gov't","Research Support, U.S. Gov't, P.H.S."],"s2_fields_of_study":["Biology","Medicine"],"reference_count":28,"citation_count":52,"influential_citation_count":4,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Animals","mj":false,"ui":"D000818"},{"d":"CD28 Antigens","mj":false,"qs":[{"q":"physiology","mj":true,"ui":"Q000502"}],"ui":"D018106"},{"d":"CD4-Positive T-Lymphocytes","mj":false,"qs":[{"q":"immunology","mj":false,"ui":"Q000276"}],"ui":"D015496"},{"d":"Histocompatibility Antigens","mj":false,"qs":[{"q":"immunology","mj":true,"ui":"Q000276"}],"ui":"D006649"},{"d":"Mice","mj":false,"ui":"D051379"},{"d":"Mice, Inbred BALB C","mj":false,"ui":"D008807"},{"d":"Mice, Inbred C3H","mj":false,"ui":"D008809"},{"d":"Mice, Inbred C57BL","mj":false,"ui":"D008810"},{"d":"Minor Histocompatibility Antigens","mj":false,"qs":[{"q":"immunology","mj":true,"ui":"Q000276"}],"ui":"D015778"}],"chemicals":[{"n":"CD28 Antigens","ui":"D018106","reg":"0"},{"n":"Histocompatibility Antigens","ui":"D006649","reg":"0"},{"n":"Minor Histocompatibility Antigens","ui":"D015778","reg":"0"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://journals.aai.org/jimmunol/article-pdf/162/5/2467/1102158/im059902467o.pdf","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/81e2c0ab0d10ad6079d9e60cd60e0f08fcfd44cf","s2_open_access_license":null,"s2_open_access_status":"BRONZE","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Comparative study of alloimmune responses against major and minor histocompatibility Ags has been limited by the lack of suitable assays. Here, we use a bioassay that permits tracking of alloreactive CD4+ T cell populations as they proliferate in response to major or minor histocompatibility Ags in vivo. Division of alloreactive CD4+ T cells proceeded more rapidly in response to major histocompatibility Ags than minor Ags, although CD4+ T cells alloreactive to minor Ags had a similar capacity to divide successively up to eight times after stimulation. Allorecognition of minor histocompatibility Ags was highly dependent on CD28 costimulation, with the frequency of CD4+ T cells proliferating in response to minor Ags in the absence of CD28 costimulation reduced up to 20-fold. These findings highlight differences in signaling processes that lead to allorecognition of major and minor histocompatibility Ags and have implications on the design of interventions aimed at abrogating these responses.","claims":[{"public_id":"cl_86cec17397244dae50053c9985284238","status":"active","text":"Alloreactive CD4+ T cells divide more rapidly in response to major histocompatibility antigens than to minor histocompatibility antigens in vivo.","confidence":0.98,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_86cec17397244dae50053c9985284238"},{"public_id":"cl_a0f4ce3eaffbf4734451f5618e692ded","status":"active","text":"Allorecognition of minor histocompatibility antigens is highly dependent on CD28 costimulation, with proliferating CD4+ T-cell frequency reduced up to 20-fold when CD28 costimulation is absent.","confidence":0.98,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_a0f4ce3eaffbf4734451f5618e692ded"},{"public_id":"cl_598c0fbc0cbbe0fab207b565dd60cf00","status":"active","text":"CD4+ T cells alloreactive to minor histocompatibility antigens can undergo successive division up to eight times after stimulation.","confidence":0.94,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_598c0fbc0cbbe0fab207b565dd60cf00"},{"public_id":"cl_e1330350baa582788094d753a0adf850","status":"active","text":"The bioassay enables in vivo tracking of alloreactive CD4+ T-cell proliferation in response to major or minor histocompatibility antigens.","confidence":0.92,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_e1330350baa582788094d753a0adf850"}],"concepts":[{"public_id":"co_055b75d190bb668ea882ab575463c5d8","status":"active","name":"division kinetics","description":"The timing and rate at which responding T cells undergo successive cell divisions.","types":["process"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_055b75d190bb668ea882ab575463c5d8"},{"public_id":"co_22f7811126a422319fe3433d5fe691fb","status":"active","name":"allorecognition","description":"Recognition of alloantigens by T cells that initiates an immune response to non-self histocompatibility antigens.","types":["immune 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approach"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_857878678d6640cab29918f67c46f2ed"},{"public_id":"co_9fae3aefb781819d16f6db7e2ea5648a","status":"active","name":"bioassay","description":"An experimental assay used to track proliferative responses of alloreactive T cells in vivo.","types":["assay"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_9fae3aefb781819d16f6db7e2ea5648a"},{"public_id":"co_a35baf725e323674008656d4a94b4d22","status":"active","name":"CD28 costimulation","description":"A costimulatory signaling pathway provided through CD28 that supports T-cell activation and proliferation.","types":["signaling 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cells"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_bc594aea4f38ea21d19b1ba57650d3a5"},{"public_id":"co_d738d0907e0b4d2aab8de57b576bd48b","status":"active","name":"major histocompatibility antigens","description":"Histocompatibility antigens that elicit strong allogeneic T-cell responses.","types":["antigen"],"aliases":["major histocompatibility Ags","major Ags"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_d738d0907e0b4d2aab8de57b576bd48b"},{"public_id":"co_f20c0320bc787c815701bd492e4b665d","status":"active","name":"minor histocompatibility antigens","description":"Polymorphic histocompatibility antigens that can trigger allogeneic T-cell responses.","types":["antigen"],"aliases":["minor histocompatibility Ags","minor Ags"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous 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