{"corpus_id":27984058,"paper_sha":"70c088d26c82a1c3e9938bc76e0ace2c6378ebe1","doi":"10.1016/j.pedneo.2017.10.010","arxiv_id":null,"pmid":29150336,"pmcid":null,"mag_id":2766071748,"dblp_id":null,"acl_id":null,"title":"Urinary tract infections in neonates with unexplained pathological indirect hyperbilirubinemia: Prevalence and significance.","year":2017,"publication_date":"2017-10-01","venue":"Pediatrics and Neonatology","journal":{"name":"Pediatrics and neonatology","pages":"\n          305-309\n        ","volume":"59 3"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article"],"s2_fields_of_study":["Medicine"],"reference_count":21,"citation_count":26,"influential_citation_count":0,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Female","mj":false,"ui":"D005260"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Hyperbilirubinemia","mj":false,"qs":[{"q":"etiology","mj":true,"ui":"Q000209"}],"ui":"D006932"},{"d":"Infant, Newborn","mj":false,"ui":"D007231"},{"d":"Jaundice","mj":false,"qs":[{"q":"etiology","mj":false,"ui":"Q000209"}],"ui":"D007565"},{"d":"Kidney","mj":false,"qs":[{"q":"diagnostic imaging","mj":false,"ui":"Q000000981"}],"ui":"D007668"},{"d":"Male","mj":false,"ui":"D008297"},{"d":"Phototherapy","mj":false,"ui":"D010789"},{"d":"Prevalence","mj":false,"ui":"D015995"},{"d":"Ultrasonography","mj":false,"ui":"D014463"},{"d":"Urinary Tract Infections","mj":false,"qs":[{"q":"complications","mj":false,"ui":"Q000150"},{"q":"diagnostic imaging","mj":false,"ui":"Q000000981"},{"q":"epidemiology","mj":true,"ui":"Q000453"}],"ui":"D014552"}],"chemicals":null,"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"http://www.pediatr-neonatol.com/article/S1875957217300566/pdf","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/70c088d26c82a1c3e9938bc76e0ace2c6378ebe1","s2_open_access_license":"CCBYNCND","s2_open_access_status":"GOLD","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"BACKGROUND\nIt is controversial to test for urinary tract infection (UTI) in patients with unexplained indirect hyperbilirubinemia in the first 2 weeks of life. We aimed to study the prevalence and significance of UTIs in such neonates who were requiring phototherapy.\n\n\nMETHODS\nSubjects were 2- to 14-day-old neonates with indirect bilirubin levels above phototherapy limit with no other abnormality in their bilirubinaemia-related etiologic workup. UTI was diagnosed by 2 consecutive positive cultures obtained by catheterisation, documenting growth of >10,000 colonies of the same microorganism with consistent antibiograms. The UTI (+) patients were evaluated by renal ultrasonography (US), and some were followed up for possible recurrent UTI.\n\n\nRESULTS\n262 neonates were included in the study. UTI prevalence was 12.2%, and bacteraemia was 6.2% among UTI (+) patients. The two most common pathogens (81.2%) were Escherichiacoli and Klebsiella. pneumonia. All UTI (+) patients had undergone US, revealing 12.5% pelvicaliectasis, other 12.5% increased renal parenchymal echogenicity, 3.1% concurrent pelvicaliectasis and increased renal parenchymal echogenicity. 53.1% of UTI (+) patients had undergone follow-up, after which 23.5% recurrent UTI were found at the end of a mean of 52 months.\n\n\nCONCLUSION\nWe suggest that the neonates with unexplained pathological jaundice should be tested for possible UTI. Consequently, all newborns with UTI shall be evaluated by the urinary US and followed up for recurrent UTI.","claims":[{"public_id":"cl_672e93576c5c4e75590527620497f5ec","status":"active","text":"Among 262 neonates with unexplained indirect hyperbilirubinemia requiring phototherapy, urinary tract infection prevalence was 12.2%.","confidence":0.98,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_672e93576c5c4e75590527620497f5ec"},{"public_id":"cl_1026f92b47b8d6e6687dcce17f6831e3","status":"active","text":"Bacteraemia occurred in 6.2% of neonates with urinary tract infection.","confidence":0.96,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_1026f92b47b8d6e6687dcce17f6831e3"},{"public_id":"cl_a2d2b5c1fdf4747fd74826c6959ffbc1","status":"active","text":"Escherichia coli and Klebsiella pneumoniae were the most common pathogens, accounting for 81.2% of urinary tract infection cases.","confidence":0.97,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_a2d2b5c1fdf4747fd74826c6959ffbc1"},{"public_id":"cl_3795f6ac6dcdfd00dd99fbf40d963334","status":"active","text":"Follow-up of 53.1% of urinary tract infection-positive neonates found recurrent urinary tract infection in 23.5% after a mean of 52 months.","confidence":0.95,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous 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cases.","confidence":0.9,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_a503bdf305637431f89d653082307674"}],"concepts":[{"public_id":"co_3adfa34764c7a168a8c091693a226836","status":"active","name":"neonates with unexplained indirect hyperbilirubinemia requiring phototherapy","description":"Newborn infants aged 2 to 14 days with indirect bilirubin above the phototherapy threshold and no other identified etiologic abnormality.","types":["patient group"],"aliases":["neonates with unexplained pathological indirect hyperbilirubinemia"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_3adfa34764c7a168a8c091693a226836"},{"public_id":"co_428e42e30dac0042f8bb824f02e2e814","status":"active","name":"urinary 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of urinary tract infection-positive neonates over time to detect recurrence.","types":["study procedure"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_539f2c0a65ff28de6839fff9874acbc4"},{"public_id":"co_8abccd1c90336908fec58f6a40f421aa","status":"active","name":"recurrent urinary tract infection","description":"A repeat urinary tract infection occurring during follow-up after the initial infection episode.","types":["outcome"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_8abccd1c90336908fec58f6a40f421aa"},{"public_id":"co_9b76aa2163b5cbdf0dcf34b6f71da007","status":"active","name":"UTI prevalence","description":"The proportion of studied neonates diagnosed with 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