{"corpus_id":28713406,"paper_sha":"bdceb761a3fa957dcc2d28b5df546e15dd7f7721","doi":"10.7883/yoken.63.271","arxiv_id":null,"pmid":20657067,"pmcid":null,"mag_id":1514820657,"dblp_id":null,"acl_id":null,"title":"Antibacterial activity of Psidium guajava leaf and bark against multidrug-resistant Vibrio cholerae: implication for cholera control.","year":2010,"publication_date":"2010-07-01","venue":"Japanese journal of infectious diseases (Print)","journal":{"name":"Japanese journal of infectious diseases","pages":"\n          271-4\n        ","volume":"63 4"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, Non-U.S. Gov't"],"s2_fields_of_study":["Biology","Medicine","Environmental Science"],"reference_count":24,"citation_count":63,"influential_citation_count":2,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Anti-Bacterial Agents","mj":false,"qs":[{"q":"isolation & purification","mj":false,"ui":"Q000302"},{"q":"pharmacology","mj":true,"ui":"Q000494"}],"ui":"D000900"},{"d":"Bangladesh","mj":false,"ui":"D001459"},{"d":"Cholera","mj":false,"qs":[{"q":"drug therapy","mj":false,"ui":"Q000188"},{"q":"microbiology","mj":true,"ui":"Q000382"}],"ui":"D002771"},{"d":"Drug Resistance, Multiple, Bacterial","mj":true,"ui":"D024901"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Microbial Sensitivity Tests","mj":false,"ui":"D008826"},{"d":"Microbial Viability","mj":false,"qs":[{"q":"drug effects","mj":false,"ui":"Q000187"}],"ui":"D050296"},{"d":"Plant Bark","mj":false,"qs":[{"q":"chemistry","mj":false,"ui":"Q000737"}],"ui":"D024301"},{"d":"Plant Extracts","mj":false,"qs":[{"q":"isolation & purification","mj":false,"ui":"Q000302"},{"q":"pharmacology","mj":true,"ui":"Q000494"}],"ui":"D010936"},{"d":"Plant Leaves","mj":false,"qs":[{"q":"chemistry","mj":false,"ui":"Q000737"}],"ui":"D018515"},{"d":"Psidium","mj":false,"qs":[{"q":"chemistry","mj":true,"ui":"Q000737"}],"ui":"D031647"},{"d":"Vibrio cholerae O1","mj":false,"qs":[{"q":"drug effects","mj":true,"ui":"Q000187"}],"ui":"D041241"}],"chemicals":[{"n":"Anti-Bacterial Agents","ui":"D000900","reg":"0"},{"n":"Plant Extracts","ui":"D010936","reg":"0"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://www.jstage.jst.go.jp/article/yoken/63/4/63_63.271/_pdf","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/bdceb761a3fa957dcc2d28b5df546e15dd7f7721","s2_open_access_license":null,"s2_open_access_status":"BRONZE","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"In clinical cholera, a 3-day course of antibiotic complements extensive rehydration therapy by reducing stool volume, shortening the illness, and averting death. However, antibiotic therapy, which has lifesaving implications for cholera, is often hindered due to multidrug resistance in Vibrio cholerae, the cause of cholera. Crude aqueous mixture and water soluble methanol extract from leaf and bark of Psidium guajava, a tropical fruit guava of the family Myrtaceae, showed strong antibacterial activity against multidrug-resistant V. cholerae O1. The in vitro minimum inhibitory concentration of the crude aqueous mixture and water soluble methanol extract, which was bactericidal against 10(7) CFU/mL of V. cholerae was determined to be 1,250 microg/mL and 850 microg/mL, respectively. The antibacterial activity of P. guajava was stable at 100 degrees C for 15-20 min, suggesting nonprotein nature of the active component. The growth of V. cholerae in rice oral rehydration saline (ORS) was completely inhibited when 10 mg/mL (wt/vol) of crude aqueous mixture was premixed with the ORS in a ratio of 1:7 (vol. extract/vol. ORS). 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