{"corpus_id":28827417,"paper_sha":"7c91725fa89a8c8d1f3a4f6c96dc54afcdd1bb66","doi":"10.1111/jcmm.13256","arxiv_id":null,"pmid":28661035,"pmcid":"5706566","mag_id":2728740126,"dblp_id":null,"acl_id":null,"title":"Up‐regulated basigin‐2 in microglia induced by hypoxia promotes retinal angiogenesis","year":2017,"publication_date":"2017-06-29","venue":"Journal of Cellular and Molecular Medicine","journal":{"name":"Journal of Cellular and Molecular Medicine","pages":"3467 - 3480","volume":"21"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article"],"s2_fields_of_study":["Biology","Medicine","Environmental Science"],"reference_count":62,"citation_count":38,"influential_citation_count":1,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Basigin","mj":false,"qs":[{"q":"genetics","mj":true,"ui":"Q000235"},{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D051926"},{"d":"Cell Hypoxia","mj":false,"ui":"D015687"},{"d":"Cell Movement","mj":false,"ui":"D002465"},{"d":"Culture Media, Conditioned","mj":false,"qs":[{"q":"pharmacology","mj":false,"ui":"Q000494"}],"ui":"D017077"},{"d":"Endothelial Cells","mj":false,"qs":[{"q":"drug effects","mj":false,"ui":"Q000187"},{"q":"metabolism","mj":false,"ui":"Q000378"},{"q":"pathology","mj":false,"ui":"Q000473"}],"ui":"D042783"},{"d":"Gene Expression Regulation","mj":false,"ui":"D005786"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Hypoxia","mj":false,"qs":[{"q":"genetics","mj":true,"ui":"Q000235"},{"q":"metabolism","mj":false,"ui":"Q000378"},{"q":"pathology","mj":false,"ui":"Q000473"}],"ui":"D000860"},{"d":"Insulin-Like Growth Factor I","mj":false,"qs":[{"q":"genetics","mj":false,"ui":"Q000235"},{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D007334"},{"d":"Mice","mj":false,"ui":"D051379"},{"d":"Mice, Inbred C57BL","mj":false,"ui":"D008810"},{"d":"Microglia","mj":false,"qs":[{"q":"drug effects","mj":true,"ui":"Q000187"},{"q":"metabolism","mj":false,"ui":"Q000378"},{"q":"pathology","mj":false,"ui":"Q000473"}],"ui":"D017628"},{"d":"Oxygen","mj":false,"qs":[{"q":"pharmacology","mj":true,"ui":"Q000494"}],"ui":"D010100"},{"d":"Phosphatidylinositol 3-Kinases","mj":false,"qs":[{"q":"genetics","mj":false,"ui":"Q000235"},{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D019869"},{"d":"Primary Cell Culture","mj":false,"ui":"D061251"},{"d":"Proto-Oncogene Proteins c-akt","mj":false,"qs":[{"q":"genetics","mj":false,"ui":"Q000235"},{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D051057"},{"d":"Retina","mj":false,"qs":[{"q":"drug effects","mj":true,"ui":"Q000187"},{"q":"metabolism","mj":false,"ui":"Q000378"},{"q":"pathology","mj":false,"ui":"Q000473"}],"ui":"D012160"},{"d":"Retinal Neovascularization","mj":false,"qs":[{"q":"genetics","mj":true,"ui":"Q000235"},{"q":"metabolism","mj":false,"ui":"Q000378"},{"q":"pathology","mj":false,"ui":"Q000473"}],"ui":"D015861"},{"d":"Retinitis","mj":false,"qs":[{"q":"genetics","mj":true,"ui":"Q000235"},{"q":"metabolism","mj":false,"ui":"Q000378"},{"q":"pathology","mj":false,"ui":"Q000473"}],"ui":"D012173"},{"d":"Signal Transduction","mj":false,"ui":"D015398"}],"chemicals":[{"n":"Bsg protein, mouse","ui":"C497887","reg":"0"},{"n":"Culture Media, Conditioned","ui":"D017077","reg":"0"},{"n":"insulin-like growth factor-1, mouse","ui":"C519530","reg":"0"},{"n":"Basigin","ui":"D051926","reg":"136894-56-9"},{"n":"Insulin-Like Growth Factor I","ui":"D007334","reg":"67763-96-6"},{"n":"Phosphatidylinositol 3-Kinases","ui":"D019869","reg":"EC 2.7.1.-"},{"n":"Proto-Oncogene Proteins c-akt","ui":"D051057","reg":"EC 2.7.11.1"},{"n":"Oxygen","ui":"D010100","reg":"S88TT14065"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcmm.13256","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/7c91725fa89a8c8d1f3a4f6c96dc54afcdd1bb66","s2_open_access_license":"CCBY","s2_open_access_status":"GOLD","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Retinal microglia cells contribute to vascular angiogenesis and vasculopathy induced by relative hypoxia. However, its concrete molecular mechanisms in shaping retinal angiogenesis have not been elucidated. Basigin, being involved in tumour neovasculogenesis, is explored to exert positive effects on retinal angiogenesis induced by microglia. Therefore, we set out to investigate the expression of basigin using a well‐characterized mouse model of oxygen‐induced retinopathy, which recapitulated hypoxia‐induced aberrant neovessel growth. Our results elucidate that basigin is overexpressed in microglia, which accumulating in retinal angiogenic sprouts. In vitro, conditioned media from microglia BV2 under hypoxia treatment increase migration and tube formation of retinal capillary endothelia cells, compared with media from normoxic condition. The angiogenic capacity of BV2 is inhibited after basigin knockdown by small interfering RNAs. A new molecular mechanism for high angiogenic capacity, whereby microglia cells release basigin via up‐regulation of PI3K‐AKT and IGF‐1 pathway to induce angiogenesis is unveiled. Collectively, our results demonstrate that basigin from hypoxic microglia plays a pivotal pro‐angiogenic role, providing new insights into microglia‐promoting retinal angiogenesis.","claims":[{"public_id":"cl_0d1beafef25944391b1fe07817318cea","status":"active","text":"Basigin is overexpressed in microglia accumulating in retinal angiogenic sprouts in a mouse model of oxygen-induced retinopathy.","confidence":0.95,"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_0d1beafef25944391b1fe07817318cea"},{"public_id":"cl_00458450e287a44567ebea438b313238","status":"active","text":"Basigin knockdown by small interfering RNAs inhibits the angiogenic capacity of BV2 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