{"corpus_id":28847278,"paper_sha":"bc62cf38e98260658ba9b62a47480a043b2a6bbd","doi":"10.1074/jbc.M202771200","arxiv_id":null,"pmid":12029087,"pmcid":null,"mag_id":2078868629,"dblp_id":null,"acl_id":null,"title":"Endostatin Blocks Vascular Endothelial Growth Factor-mediated Signaling via Direct Interaction with KDR/Flk-1*","year":2002,"publication_date":"2002-08-02","venue":"Journal of Biological Chemistry","journal":{"name":"The Journal of Biological Chemistry","pages":"27872 - 27879","volume":"277"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, Non-U.S. Gov't"],"s2_fields_of_study":["Medicine","Chemistry"],"reference_count":29,"citation_count":425,"influential_citation_count":23,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Antineoplastic Agents","mj":false,"qs":[{"q":"pharmacology","mj":false,"ui":"Q000494"}],"ui":"D000970"},{"d":"Cell Division","mj":false,"qs":[{"q":"drug effects","mj":false,"ui":"Q000187"}],"ui":"D002455"},{"d":"Cell Membrane","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D002462"},{"d":"Cells, Cultured","mj":false,"ui":"D002478"},{"d":"Chemotaxis","mj":false,"qs":[{"q":"drug effects","mj":false,"ui":"Q000187"}],"ui":"D002633"},{"d":"Collagen","mj":false,"qs":[{"q":"pharmacology","mj":true,"ui":"Q000494"}],"ui":"D003094"},{"d":"Collagen Type XVIII","mj":false,"ui":"D043170"},{"d":"Endostatins","mj":false,"ui":"D043169"},{"d":"Endothelial Growth Factors","mj":false,"qs":[{"q":"antagonists & inhibitors","mj":false,"ui":"Q000037"},{"q":"metabolism","mj":true,"ui":"Q000378"},{"q":"pharmacology","mj":true,"ui":"Q000494"}],"ui":"D016228"},{"d":"Endothelium, Vascular","mj":false,"qs":[{"q":"cytology","mj":false,"ui":"Q000166"},{"q":"drug effects","mj":false,"ui":"Q000187"},{"q":"physiology","mj":true,"ui":"Q000502"}],"ui":"D004730"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Kinetics","mj":false,"ui":"D007700"},{"d":"Lymphokines","mj":false,"qs":[{"q":"antagonists & inhibitors","mj":false,"ui":"Q000037"},{"q":"metabolism","mj":true,"ui":"Q000378"},{"q":"pharmacology","mj":true,"ui":"Q000494"}],"ui":"D008222"},{"d":"Peptide Fragments","mj":false,"qs":[{"q":"pharmacology","mj":true,"ui":"Q000494"}],"ui":"D010446"},{"d":"Receptor Protein-Tyrosine Kinases","mj":false,"qs":[{"q":"drug effects","mj":false,"ui":"Q000187"},{"q":"physiology","mj":true,"ui":"Q000502"}],"ui":"D020794"},{"d":"Receptors, Growth Factor","mj":false,"qs":[{"q":"drug effects","mj":false,"ui":"Q000187"},{"q":"physiology","mj":true,"ui":"Q000502"}],"ui":"D017978"},{"d":"Receptors, Vascular Endothelial Growth Factor","mj":false,"ui":"D040262"},{"d":"Recombinant Proteins","mj":false,"qs":[{"q":"pharmacology","mj":false,"ui":"Q000494"}],"ui":"D011994"},{"d":"Signal Transduction","mj":false,"qs":[{"q":"drug effects","mj":false,"ui":"Q000187"},{"q":"physiology","mj":true,"ui":"Q000502"}],"ui":"D015398"},{"d":"Umbilical Veins","mj":false,"ui":"D014471"},{"d":"Vascular Endothelial Growth Factor A","mj":false,"ui":"D042461"},{"d":"Vascular Endothelial Growth Factors","mj":false,"ui":"D042442"}],"chemicals":[{"n":"Antineoplastic Agents","ui":"D000970","reg":"0"},{"n":"Collagen Type XVIII","ui":"D043170","reg":"0"},{"n":"Endostatins","ui":"D043169","reg":"0"},{"n":"Endothelial Growth Factors","ui":"D016228","reg":"0"},{"n":"Lymphokines","ui":"D008222","reg":"0"},{"n":"Peptide Fragments","ui":"D010446","reg":"0"},{"n":"Receptors, Growth Factor","ui":"D017978","reg":"0"},{"n":"Recombinant Proteins","ui":"D011994","reg":"0"},{"n":"VEGFA protein, human","ui":"C467484","reg":"0"},{"n":"Vascular Endothelial Growth Factor A","ui":"D042461","reg":"0"},{"n":"Vascular Endothelial Growth Factors","ui":"D042442","reg":"0"},{"n":"Collagen","ui":"D003094","reg":"9007-34-5"},{"n":"Receptor Protein-Tyrosine Kinases","ui":"D020794","reg":"EC 2.7.10.1"},{"n":"Receptors, Vascular Endothelial Growth Factor","ui":"D040262","reg":"EC 2.7.10.1"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"http://www.jbc.org/article/S0021925819662514/pdf","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/bc62cf38e98260658ba9b62a47480a043b2a6bbd","s2_open_access_license":"CCBY","s2_open_access_status":"HYBRID","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Endostatin, a fragment of collagen XVIII, is a potent anti-angiogenic protein, but the molecular mechanism of its action is not yet clear. 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