{"corpus_id":30136014,"paper_sha":"0c66d8d0802e0d650a33ed33ca0b9f96f22894f1","doi":"10.4049/jimmunol.144.8.3028","arxiv_id":null,"pmid":2139075,"pmcid":null,"mag_id":1512110246,"dblp_id":null,"acl_id":null,"title":"Cytokine receptors and B cell functions. I. Recombinant soluble receptors specifically inhibit IL-1- and IL-4-induced B cell activities in vitro.","year":1990,"publication_date":"1990-04-15","venue":"Journal of Immunology","journal":{"name":"Journal of immunology","pages":"\n          3028-33\n        ","volume":"144 8"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article"],"s2_fields_of_study":["Biology","Medicine"],"reference_count":0,"citation_count":116,"influential_citation_count":1,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Antigens, Differentiation, B-Lymphocyte","mj":false,"qs":[{"q":"analysis","mj":false,"ui":"Q000032"}],"ui":"D000944"},{"d":"B-Lymphocytes","mj":false,"qs":[{"q":"physiology","mj":true,"ui":"Q000502"}],"ui":"D001402"},{"d":"Binding, Competitive","mj":false,"ui":"D001667"},{"d":"Cell Differentiation","mj":false,"ui":"D002454"},{"d":"Histocompatibility Antigens Class II","mj":false,"qs":[{"q":"analysis","mj":false,"ui":"Q000032"}],"ui":"D000949"},{"d":"Immunoglobulins","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D007136"},{"d":"Interleukin-1","mj":false,"qs":[{"q":"physiology","mj":true,"ui":"Q000502"}],"ui":"D007375"},{"d":"Interleukin-4","mj":false,"qs":[{"q":"physiology","mj":true,"ui":"Q000502"}],"ui":"D015847"},{"d":"Lymphocyte Activation","mj":false,"ui":"D008213"},{"d":"Mice","mj":false,"ui":"D051379"},{"d":"Mice, Inbred C57BL","mj":false,"ui":"D008810"},{"d":"Receptors, Fc","mj":false,"qs":[{"q":"analysis","mj":false,"ui":"Q000032"}],"ui":"D011961"},{"d":"Receptors, IgE","mj":false,"ui":"D017455"},{"d":"Receptors, Immunologic","mj":false,"qs":[{"q":"physiology","mj":true,"ui":"Q000502"}],"ui":"D011971"},{"d":"Receptors, Interleukin-1","mj":false,"ui":"D017472"},{"d":"Receptors, Interleukin-4","mj":false,"ui":"D019948"},{"d":"Receptors, Mitogen","mj":false,"qs":[{"q":"physiology","mj":true,"ui":"Q000502"}],"ui":"D011975"},{"d":"Recombinant Proteins","mj":false,"ui":"D011994"},{"d":"Solubility","mj":false,"ui":"D012995"}],"chemicals":[{"n":"Antigens, Differentiation, B-Lymphocyte","ui":"D000944","reg":"0"},{"n":"Histocompatibility Antigens Class II","ui":"D000949","reg":"0"},{"n":"Immunoglobulins","ui":"D007136","reg":"0"},{"n":"Interleukin-1","ui":"D007375","reg":"0"},{"n":"Receptors, Fc","ui":"D011961","reg":"0"},{"n":"Receptors, IgE","ui":"D017455","reg":"0"},{"n":"Receptors, Immunologic","ui":"D011971","reg":"0"},{"n":"Receptors, Interleukin-1","ui":"D017472","reg":"0"},{"n":"Receptors, Interleukin-4","ui":"D019948","reg":"0"},{"n":"Receptors, Mitogen","ui":"D011975","reg":"0"},{"n":"Recombinant Proteins","ui":"D011994","reg":"0"},{"n":"Interleukin-4","ui":"D015847","reg":"207137-56-2"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://journals.aai.org/jimmunol/article-pdf/144/8/3028/1047627/3028.pdf","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/0c66d8d0802e0d650a33ed33ca0b9f96f22894f1","s2_open_access_license":null,"s2_open_access_status":"BRONZE","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"IL-1 and IL-4 are important mediators of B cell growth and differentiation. The cell-surface receptors for these cytokines have recently been cloned and recombinant soluble receptors have been produced that bind their respective ligand. The ability of soluble forms of the murine IL-1R (sIL-1R) and IL-4R (sIL-4R) to inhibit B cell functions in vitro was examined. Proliferation of B cells treated with anti-Ig plus IL-1 or IL-4 was inhibited by the appropriate soluble receptor. sIL-4R also inhibited IL-4-dependent B cell differentiation as measured by: induction of IgG1 and IgE secretion by LPS blasts, down-regulation of IgG3 secretion by LPS blasts, increased Ia expression, and increased Fc epsilon R (CD23) expression. The inhibitory effects of the soluble receptors were found to be highly specific in that sIL-4R had no effect on IL-1-induced B cell activity and sIL-1R had no effect on IL-4 activity, further demonstrating the existence of two independent pathways of B cell activation directed by IL-1 and IL-4.","claims":[{"public_id":"cl_eab651897782a7e6224cfee19b08c2ff","status":"active","text":"B cell proliferation induced by anti-Ig plus IL-1 or IL-4 is inhibited by the appropriate soluble receptor.","confidence":0.95,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_eab651897782a7e6224cfee19b08c2ff"},{"public_id":"cl_5a71e172080bfefa6a6a6dc0b0763d0a","status":"active","text":"IL-1 and IL-4 direct two independent pathways of B cell activation.","confidence":0.92,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous 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