{"corpus_id":31393853,"paper_sha":"cb62318cbc61114763e158c2b8dc366af9767c1d","doi":"10.3748/wjg.v19.i45.8211","arxiv_id":null,"pmid":24363511,"pmcid":"PMC3857443","mag_id":2100915223,"dblp_id":null,"acl_id":null,"title":"Nickel trafficking system responsible for urease maturation in Helicobacter pylori.","year":2013,"publication_date":"2013-12-07","venue":"World Journal of Gastroenterology","journal":{"name":"World journal of gastroenterology","pages":"\n          8211-8\n        ","volume":"19 45"},"journal_issn":null,"journal_title":null,"publication_types":["Review","JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, Non-U.S. Gov't","Review"],"s2_fields_of_study":["Biology","Medicine","Chemistry"],"reference_count":89,"citation_count":29,"influential_citation_count":0,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Bacterial Proteins","mj":false,"qs":[{"q":"chemistry","mj":false,"ui":"Q000737"},{"q":"metabolism","mj":true,"ui":"Q000378"}],"ui":"D001426"},{"d":"Biological Transport","mj":false,"ui":"D001692"},{"d":"Helicobacter Infections","mj":false,"qs":[{"q":"microbiology","mj":true,"ui":"Q000382"}],"ui":"D016481"},{"d":"Helicobacter pylori","mj":false,"qs":[{"q":"enzymology","mj":true,"ui":"Q000201"},{"q":"pathogenicity","mj":false,"ui":"Q000472"}],"ui":"D016480"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Hydrogen-Ion Concentration","mj":false,"ui":"D006863"},{"d":"Metalloproteins","mj":false,"qs":[{"q":"chemistry","mj":false,"ui":"Q000737"},{"q":"metabolism","mj":true,"ui":"Q000378"}],"ui":"D008667"},{"d":"Models, Molecular","mj":false,"ui":"D008958"},{"d":"Molecular Chaperones","mj":false,"ui":"D018832"},{"d":"Nickel","mj":false,"qs":[{"q":"metabolism","mj":true,"ui":"Q000378"}],"ui":"D009532"},{"d":"Protein Conformation","mj":false,"ui":"D011487"},{"d":"Repressor Proteins","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D012097"},{"d":"Stomach","mj":false,"qs":[{"q":"microbiology","mj":true,"ui":"Q000382"}],"ui":"D013270"},{"d":"Urease","mj":false,"qs":[{"q":"chemistry","mj":false,"ui":"Q000737"},{"q":"metabolism","mj":true,"ui":"Q000378"}],"ui":"D014510"}],"chemicals":[{"n":"Bacterial Proteins","ui":"D001426","reg":"0"},{"n":"Metalloproteins","ui":"D008667","reg":"0"},{"n":"Molecular Chaperones","ui":"D018832","reg":"0"},{"n":"NikR protein, Helicobacter pylori","ui":"C523724","reg":"0"},{"n":"Repressor Proteins","ui":"D012097","reg":"0"},{"n":"Nickel","ui":"D009532","reg":"7OV03QG267"},{"n":"Urease","ui":"D014510","reg":"EC 3.5.1.5"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Helicobacter pylori (H. pylori) is a common human pathogen responsible for various gastric diseases. This bacterium relies on the production of urease and hydrogenase to inhabit the acidic environment of the stomach. Nickel is an essential cofactor for urease and hydrogenase. H. pylori has to uptake sufficient nickel ions for the maturation of urease, and on the other way, to prevent the toxic effects of excessive nickel ions. Therefore, H. pylori has to strike a delicate balance between the import of nickel ions, its efficient intracellular storage, and delivery to nickel-dependent metalloenzymes when required. The assembly and maturation of the urease enzyme is a complex and timely ordered process, requiring various regulatory, uptake, chaperone and accessory proteins. In this review, we focus on several nickel trafficking proteins involved in urease maturation: NikR, NixA, HypAB, UreEFGH, HspA, Hpn and Hpnl. The work will deepen our understanding of how this pathogenic bacterium adapts to severe habitant environments in the host.","claims":[{"public_id":"cl_9934aa9faf3698477f6b6a1103a4365c","status":"active","text":"NikR, NixA, HypAB, UreEFGH, HspA, Hpn, and Hpnl are the nickel trafficking proteins highlighted as involved in urease maturation in Helicobacter pylori.","confidence":0.98,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_9934aa9faf3698477f6b6a1103a4365c"},{"public_id":"cl_9245cb83171b87fb8210f14987f4bfbc","status":"active","text":"Urease assembly and maturation is a complex and temporally ordered process requiring regulatory, uptake, chaperone, and accessory proteins.","confidence":0.95,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous 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