{"corpus_id":32430993,"paper_sha":"654a4d5ad98430dd8e46dae8193fda1cbe6257ed","doi":"10.1016/j.celrep.2017.10.052","arxiv_id":null,"pmid":29141224,"pmcid":"PMC5709812","mag_id":2770036612,"dblp_id":null,"acl_id":null,"title":"Genetic and Genomic Characterization of 462 Melanoma Patient-Derived Xenografts, Tumor Biopsies, and Cell Lines.","year":2017,"publication_date":"2017-11-14","venue":"Cell Reports","journal":{"name":"Cell reports","pages":"\n          1936-1952\n        ","volume":"21 7"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article"],"s2_fields_of_study":["Biology","Medicine"],"reference_count":44,"citation_count":66,"influential_citation_count":1,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Adult","mj":false,"ui":"D000328"},{"d":"Aged","mj":false,"ui":"D000368"},{"d":"Aged, 80 and over","mj":false,"ui":"D000369"},{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Cell Line, Tumor","mj":false,"ui":"D045744"},{"d":"Female","mj":false,"ui":"D005260"},{"d":"Genome","mj":true,"ui":"D016678"},{"d":"Heterografts","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D064593"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"MAP Kinase Signaling System","mj":false,"qs":[{"q":"genetics","mj":false,"ui":"Q000235"}],"ui":"D020935"},{"d":"Male","mj":false,"ui":"D008297"},{"d":"Melanoma","mj":false,"qs":[{"q":"genetics","mj":true,"ui":"Q000235"},{"q":"pathology","mj":false,"ui":"Q000473"}],"ui":"D008545"},{"d":"Mice","mj":false,"ui":"D051379"},{"d":"Middle Aged","mj":false,"ui":"D008875"},{"d":"Mutation","mj":false,"ui":"D009154"},{"d":"Oncogenes","mj":false,"ui":"D009857"},{"d":"Repetitive Sequences, Nucleic Acid","mj":false,"ui":"D012091"}],"chemicals":null,"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"http://www.cell.com/article/S2211124717314997/pdf","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/654a4d5ad98430dd8e46dae8193fda1cbe6257ed","s2_open_access_license":"CCBYNCND","s2_open_access_status":"GOLD","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Tumor-sequencing studies have revealed the widespread genetic diversity of melanoma. Sequencing of 108 genes previously implicated in melanomagenesis was performed on 462 patient-derived xenografts (PDXs), cell lines, and tumors to identify mutational and copy number aberrations. Samples came from 371 unique individuals: 263 were naive to treatment, and 108 were previously treated with targeted therapy (34), immunotherapy (54), or both (20). Models of all previously reported major melanoma subtypes (BRAF, NRAS, NF1, KIT, and WT/WT/WT) were identified. Multiple minor melanoma subtypes were also recapitulated, including melanomas with multiple activating mutations in the MAPK-signaling pathway and chromatin-remodeling gene mutations. 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