{"corpus_id":33556798,"paper_sha":"7dd94bf9941ffa47e041adf7cd9d9084ca43aa8f","doi":"10.4049/jimmunol.105.4.938","arxiv_id":null,"pmid":4097146,"pmcid":null,"mag_id":1549364526,"dblp_id":null,"acl_id":null,"title":"The kinetics of in vivo tolerance introduction in mice.","year":1970,"publication_date":"1970-10-01","venue":"Journal of Immunology","journal":{"name":"Journal of immunology","pages":"\n          938-43\n        ","volume":"105 4"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article"],"s2_fields_of_study":["Biology","Medicine"],"reference_count":0,"citation_count":11,"influential_citation_count":0,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Antigens","mj":false,"ui":"D000941"},{"d":"Cattle","mj":false,"ui":"D002417"},{"d":"Freund's Adjuvant","mj":false,"ui":"D005620"},{"d":"Immune Tolerance","mj":true,"ui":"D007108"},{"d":"Immunity","mj":false,"ui":"D007109"},{"d":"Immunization, Passive","mj":false,"ui":"D007116"},{"d":"Injections, Intraperitoneal","mj":false,"ui":"D007274"},{"d":"Iodine Isotopes","mj":false,"ui":"D007456"},{"d":"Mice","mj":false,"ui":"D051379"},{"d":"Ornithine","mj":false,"qs":[{"q":"pharmacology","mj":false,"ui":"Q000494"}],"ui":"D009952"},{"d":"Radiation Chimera","mj":false,"ui":"D011828"},{"d":"Radionuclide Imaging","mj":false,"ui":"D011877"},{"d":"Spleen","mj":false,"qs":[{"q":"immunology","mj":false,"ui":"Q000276"}],"ui":"D013154"},{"d":"gamma-Globulins","mj":false,"ui":"D005719"}],"chemicals":[{"n":"Antigens","ui":"D000941","reg":"0"},{"n":"Iodine Isotopes","ui":"D007456","reg":"0"},{"n":"gamma-Globulins","ui":"D005719","reg":"0"},{"n":"Freund's Adjuvant","ui":"D005620","reg":"9007-81-2"},{"n":"Ornithine","ui":"D009952","reg":"E524N2IXA3"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://journals.aai.org/jimmunol/article-pdf/105/4/938/989318/ji1050040938.pdf","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/7dd94bf9941ffa47e041adf7cd9d9084ca43aa8f","s2_open_access_license":null,"s2_open_access_status":"BRONZE","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"\n C57BL/6 mice were rendered immunologically tolerant by an intraperitoneal injection of 200 μg of bovine γ globulin (BGG). An intraperitoneal injection of 1 mg of polyornithine (poly-O) given from 24 hr before to 5 hr after the injection of BGG produced immunity rather than tolerance. After 8 hr the induction of tolerance by BGG was no longer reversible by the poly-O. In a further test of the induction period of tolerance, washed spleen cells were transferred to x-irradiated recipients which were then immunized. If spleen cells were removed from donor mice as little as 4 hr after they had been injected with 2 mg of BGG, significant loss of ability to produce immunity in recipients was seen.","claims":[{"public_id":"cl_591f2da3a61bd8136bfaeee8f4a1f1df","status":"active","text":"After 8 hours, tolerance induction by bovine gamma globulin is no longer reversible by polyornithine.","confidence":0.92,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_591f2da3a61bd8136bfaeee8f4a1f1df"},{"public_id":"cl_e443e8f1557a88d7e82aacf60f804980","status":"active","text":"Intraperitoneal bovine gamma globulin induces immunological tolerance in C57BL/6 mice.","confidence":0.98,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_e443e8f1557a88d7e82aacf60f804980"},{"public_id":"cl_b702c3df8978ba37b908a60ddb174d45","status":"active","text":"Polyornithine administered from 24 hours before to 5 hours after bovine gamma globulin converts the response from tolerance to immunity.","confidence":0.95,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_b702c3df8978ba37b908a60ddb174d45"},{"public_id":"cl_aa9f79e6b61f5d18dd24306ad704505b","status":"active","text":"Washed spleen cells removed as little as 4 hours after bovine gamma globulin injection show a significant loss of ability to produce immunity in irradiated recipients.","confidence":0.94,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous 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