{"corpus_id":34983002,"paper_sha":"b786a11940ffe5e079fd0e6666ce4186b1d40d58","doi":"10.1074/JBC.M312581200","arxiv_id":null,"pmid":15229229,"pmcid":null,"mag_id":2049409526,"dblp_id":null,"acl_id":null,"title":"TEL/ETV6 Is a Signal Transducer and Activator of Transcription 3 (Stat3)-induced Repressor of Stat3 Activity*","year":2004,"publication_date":"2004-09-10","venue":"Journal of Biological Chemistry","journal":{"name":"Journal of Biological Chemistry","pages":"38787 - 38796","volume":"279"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, Non-U.S. Gov't"],"s2_fields_of_study":["Biology","Medicine"],"reference_count":53,"citation_count":32,"influential_citation_count":1,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Blotting, Western","mj":false,"ui":"D015153"},{"d":"Cell Cycle","mj":false,"ui":"D002453"},{"d":"Cell Division","mj":false,"ui":"D002455"},{"d":"Cell Line","mj":false,"ui":"D002460"},{"d":"Cell Line, Tumor","mj":false,"ui":"D045744"},{"d":"DNA","mj":false,"qs":[{"q":"chemistry","mj":false,"ui":"Q000737"}],"ui":"D004247"},{"d":"DNA-Binding Proteins","mj":false,"qs":[{"q":"metabolism","mj":true,"ui":"Q000378"},{"q":"physiology","mj":true,"ui":"Q000502"}],"ui":"D004268"},{"d":"Flow Cytometry","mj":false,"ui":"D005434"},{"d":"G1 Phase","mj":false,"ui":"D016193"},{"d":"G2 Phase","mj":false,"ui":"D016195"},{"d":"Gene Deletion","mj":false,"ui":"D017353"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Lac Operon","mj":false,"ui":"D007763"},{"d":"Luciferases","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D008156"},{"d":"Mutation","mj":false,"ui":"D009154"},{"d":"Oligonucleotide Array Sequence Analysis","mj":false,"ui":"D020411"},{"d":"Oligonucleotides","mj":false,"qs":[{"q":"chemistry","mj":false,"ui":"Q000737"}],"ui":"D009841"},{"d":"Plasmids","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D010957"},{"d":"Precipitin Tests","mj":false,"ui":"D011233"},{"d":"Protein Structure, Tertiary","mj":false,"ui":"D017434"},{"d":"Proto-Oncogene Proteins c-ets","mj":false,"ui":"D050783"},{"d":"RNA, Small Interfering","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D034741"},{"d":"Receptors, Estrogen","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D011960"},{"d":"Recombinant Proteins","mj":false,"qs":[{"q":"chemistry","mj":false,"ui":"Q000737"}],"ui":"D011994"},{"d":"Repressor Proteins","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"},{"q":"physiology","mj":true,"ui":"Q000502"}],"ui":"D012097"},{"d":"Reverse Transcriptase Polymerase Chain Reaction","mj":false,"ui":"D020133"},{"d":"STAT3 Transcription Factor","mj":false,"ui":"D050796"},{"d":"Signal Transduction","mj":false,"ui":"D015398"},{"d":"Time Factors","mj":false,"ui":"D013997"},{"d":"Trans-Activators","mj":false,"qs":[{"q":"metabolism","mj":true,"ui":"Q000378"}],"ui":"D015534"},{"d":"Transcription, Genetic","mj":false,"ui":"D014158"},{"d":"Transfection","mj":false,"ui":"D014162"},{"d":"ETS Translocation Variant 6 Protein","mj":false,"ui":"D000097764"}],"chemicals":[{"n":"DNA","ui":"D004247","reg":"9007-49-2"},{"n":"DNA-Binding Proteins","ui":"D004268","reg":"0"},{"n":"Luciferases","ui":"D008156","reg":"EC 1.13.12.-"},{"n":"Oligonucleotides","ui":"D009841","reg":"0"},{"n":"Proto-Oncogene Proteins c-ets","ui":"D050783","reg":"0"},{"n":"RNA, Small Interfering","ui":"D034741","reg":"0"},{"n":"Receptors, Estrogen","ui":"D011960","reg":"0"},{"n":"Recombinant Proteins","ui":"D011994","reg":"0"},{"n":"Repressor Proteins","ui":"D012097","reg":"0"},{"n":"STAT3 Transcription Factor","ui":"D050796","reg":"0"},{"n":"Trans-Activators","ui":"D015534","reg":"0"},{"n":"ETS Translocation Variant 6 Protein","ui":"D000097764","reg":"0"},{"n":"STAT3 protein, human","ui":"C494086","reg":"0"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"http://www.jbc.org/article/S0021925820729315/pdf","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/b786a11940ffe5e079fd0e6666ce4186b1d40d58","s2_open_access_license":"CCBY","s2_open_access_status":"HYBRID","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"The signal transducer and activator of transcription 3 (Stat3) transcription factor is required for the antiproliferative effects induced by cytokines, such as the interleukin-6 type. 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Inhibition of Stat3 activity by TEL represents a novel mechanism regulating the Stat3 signaling pathway.","claims":[{"public_id":"cl_90990c82cf4688f7dda738c45d394eca","status":"active","text":"Activation of Stat3 to moderate levels represses A375 melanoma cell proliferation by slowing cell-cycle transit.","confidence":0.99,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_90990c82cf4688f7dda738c45d394eca"},{"public_id":"cl_2ea585d859eaea0086b0f6a4ade3ddd2","status":"active","text":"Enhanced and prolonged Stat3 activity induces cell-cycle arrest and apoptosis.","confidence":0.98,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous 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