{"corpus_id":35981244,"paper_sha":"a2cbe89361ac1470493d6d2123d05f7a528436d5","doi":"10.1152/JAPPL.1986.61.1.165","arxiv_id":null,"pmid":3525502,"pmcid":null,"mag_id":2177016730,"dblp_id":null,"acl_id":null,"title":"Muscle glycogen utilization during prolonged strenuous exercise when fed carbohydrate.","year":1986,"publication_date":"1986-07-01","venue":"Journal of applied physiology","journal":{"name":"Journal of applied physiology","pages":"\n          165-72\n        ","volume":"61 1"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, Non-U.S. Gov't"],"s2_fields_of_study":["Agricultural and Food Sciences","Medicine","Chemistry"],"reference_count":24,"citation_count":1067,"influential_citation_count":74,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Adult","mj":false,"ui":"D000328"},{"d":"Blood Glucose","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D001786"},{"d":"Capillaries","mj":false,"ui":"D002196"},{"d":"Dietary Carbohydrates","mj":false,"qs":[{"q":"pharmacology","mj":true,"ui":"Q000494"}],"ui":"D004040"},{"d":"Fatty Acids, Nonesterified","mj":false,"qs":[{"q":"blood","mj":false,"ui":"Q000097"}],"ui":"D005230"},{"d":"Glycerol","mj":false,"qs":[{"q":"blood","mj":false,"ui":"Q000097"}],"ui":"D005990"},{"d":"Glycogen","mj":false,"qs":[{"q":"metabolism","mj":true,"ui":"Q000378"}],"ui":"D006003"},{"d":"Heart Rate","mj":false,"ui":"D006339"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Insulin","mj":false,"qs":[{"q":"blood","mj":false,"ui":"Q000097"}],"ui":"D007328"},{"d":"Lactates","mj":false,"qs":[{"q":"blood","mj":false,"ui":"Q000097"}],"ui":"D007773"},{"d":"Male","mj":false,"ui":"D008297"},{"d":"Muscles","mj":false,"qs":[{"q":"blood supply","mj":false,"ui":"Q000098"},{"q":"metabolism","mj":true,"ui":"Q000378"}],"ui":"D009132"},{"d":"Osmolar Concentration","mj":false,"ui":"D009994"},{"d":"Oxygen Consumption","mj":false,"ui":"D010101"},{"d":"Physical Endurance","mj":true,"ui":"D010807"},{"d":"Physical Exertion","mj":true,"ui":"D005082"},{"d":"Pulmonary Gas Exchange","mj":false,"ui":"D011659"},{"d":"Self Concept","mj":false,"ui":"D012649"},{"d":"Time Factors","mj":false,"ui":"D013997"}],"chemicals":[{"n":"Blood Glucose","ui":"D001786","reg":"0"},{"n":"Dietary Carbohydrates","ui":"D004040","reg":"0"},{"n":"Fatty Acids, Nonesterified","ui":"D005230","reg":"0"},{"n":"Insulin","ui":"D007328","reg":"0"},{"n":"Lactates","ui":"D007773","reg":"0"},{"n":"Glycogen","ui":"D006003","reg":"9005-79-2"},{"n":"Glycerol","ui":"D005990","reg":"PDC6A3C0OX"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"The purpose of this study was to determine whether the postponement of fatigue in subjects fed carbohydrate during prolonged strenuous exercise is associated with a slowing of muscle glycogen depletion. Seven endurance-trained cyclists exercised at 71 +/- 1% of maximal O2 consumption (VO2max), to fatigue, while ingesting a flavored water solution (i.e., placebo) during one trial and while ingesting a glucose polymer solution (i.e., 2.0 g/kg at 20 min and 0.4 g/kg every 20 min thereafter) during another trial. Fatigue during the placebo trial occurred after 3.02 +/- 0.19 h of exercise and was preceded by a decline (P less than 0.01) in plasma glucose to 2.5 +/- 0.5 mM and by a decline in the respiratory exchange ratio (i.e., R; from 0.85 to 0.80; P less than 0.05). Glycogen within the vastus lateralis muscle declined at an average rate of 51.5 +/- 5.4 mmol glucosyl units (GU) X kg-1 X h-1 during the first 2 h of exercise and at a slower rate (P less than 0.01) of 23.0 +/- 14.3 mmol GU X kg-1 X h-1 during the third and final hour. When fed carbohydrate, which maintained plasma glucose concentration (4.2-5.2 mM), the subjects exercised for an additional hour before fatiguing (4.02 +/- 0.33 h; P less than 0.01) and maintained their initial R (i.e., 0.86) and rate of carbohydrate oxidation throughout exercise. The pattern of muscle glycogen utilization, however, was not different during the first 3 h of exercise with the placebo or the carbohydrate feedings. The additional hour of exercise performed when fed carbohydrate was accomplished with little reliance on muscle glycogen (i.e., 5 mmol GU X kg-1 X h-1; NS) and without compromising carbohydrate oxidation. We conclude that when they are fed carbohydrate, highly trained endurance athletes are capable of oxidizing carbohydrate at relatively high rates from sources other than muscle glycogen during the latter stages of prolonged strenuous exercise and that this postpones fatigue.","claims":[{"public_id":"cl_2e15b11d6044ea894cf2f335c1190703","status":"active","text":"Carbohydrate feeding extended exercise duration to fatigue from 3.02 ± 0.19 h to 4.02 ± 0.33 h compared with placebo in endurance-trained cyclists exercising at 71% of maximal oxygen consumption.","confidence":0.97,"contributors":[{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["extraction"],"url":"https://sah.borca.ai/u/322360f1c1"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ 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endurance athletes fed carbohydrate can oxidize carbohydrate at relatively high rates from sources other than muscle glycogen during the latter stages of prolonged strenuous exercise, postponing fatigue.","confidence":0.95,"contributors":[{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["extraction"],"url":"https://sah.borca.ai/u/322360f1c1"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/claims/cl_983db8d58b4bb9efc6f33739364150c4"},{"public_id":"cl_80a6590fd92a811cf8671af946c41b04","status":"active","text":"Muscle glycogen utilization pattern in the vastus lateralis was not different during the first 3 hours of exercise between placebo and carbohydrate feeding trials.","confidence":0.97,"contributors":[{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["extraction"],"url":"https://sah.borca.ai/u/322360f1c1"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/claims/cl_80a6590fd92a811cf8671af946c41b04"},{"public_id":"cl_306b1484a269b853799a914e2601be2a","status":"active","text":"The additional hour of exercise enabled by carbohydrate feeding was accomplished with little reliance on muscle glycogen (5 mmol glucosyl units × kg⁻¹ × h⁻¹) and without compromising carbohydrate oxidation.","confidence":0.95,"contributors":[{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale 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