{"corpus_id":36066562,"paper_sha":"68a4796c7d925438f606fbe00df58dbd030558d5","doi":"10.14712/18059694.2018.95","arxiv_id":null,"pmid":15841900,"pmcid":null,"mag_id":20622852,"dblp_id":null,"acl_id":null,"title":"Acetylcholinesterase and butyrylcholinesterase--important enzymes of human body.","year":2004,"publication_date":null,"venue":"Acta medica","journal":{"name":"Acta medica","pages":"\n          215-28\n        ","volume":"47 4"},"journal_issn":null,"journal_title":null,"publication_types":["Review","JournalArticle"],"pubmed_pub_types":["Journal Article","Review"],"s2_fields_of_study":["Medicine","Chemistry"],"reference_count":111,"citation_count":125,"influential_citation_count":3,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Acetylcholinesterase","mj":false,"qs":[{"q":"chemistry","mj":false,"ui":"Q000737"},{"q":"metabolism","mj":false,"ui":"Q000378"},{"q":"physiology","mj":true,"ui":"Q000502"}],"ui":"D000110"},{"d":"Aging","mj":false,"qs":[{"q":"physiology","mj":false,"ui":"Q000502"}],"ui":"D000375"},{"d":"Alzheimer Disease","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"},{"q":"physiopathology","mj":false,"ui":"Q000503"}],"ui":"D000544"},{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Butyrylcholinesterase","mj":false,"qs":[{"q":"chemistry","mj":false,"ui":"Q000737"},{"q":"metabolism","mj":false,"ui":"Q000378"},{"q":"physiology","mj":true,"ui":"Q000502"}],"ui":"D002091"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Neurotransmitter Agents","mj":false,"qs":[{"q":"physiology","mj":true,"ui":"Q000502"}],"ui":"D018377"},{"d":"Peripheral Nervous System","mj":false,"qs":[{"q":"physiology","mj":true,"ui":"Q000502"}],"ui":"D017933"},{"d":"Receptors, Cholinergic","mj":false,"qs":[{"q":"classification","mj":false,"ui":"Q000145"},{"q":"physiology","mj":false,"ui":"Q000502"}],"ui":"D011950"}],"chemicals":[{"n":"Neurotransmitter Agents","ui":"D018377","reg":"0"},{"n":"Receptors, Cholinergic","ui":"D011950","reg":"0"},{"n":"Acetylcholinesterase","ui":"D000110","reg":"EC 3.1.1.7"},{"n":"Butyrylcholinesterase","ui":"D002091","reg":"EC 3.1.1.8"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://actamedica.lfhk.cuni.cz/media/pdf/18059694.2018.95.pdf","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/68a4796c7d925438f606fbe00df58dbd030558d5","s2_open_access_license":"CCBY","s2_open_access_status":"GOLD","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"The serine hydrolases and proteases are a ubiquitous group of enzymes that is fundamental to many critical life-functions. Human tissues have two distinct cholinesterase activities: acetylcholinesterase and butyrylcholinesterase. Acetylcholinesterase functions in the transmission of nerve impulses, whereas the physiological function of butyrylcholinesterase remains unknown. Acetylcholinesterase is one of the crucial enzymes in the central and peripheral nerve system. Organophosphates and carbamates are potent inhibitors of serine hydrolases and well suited probes for investigating the chemical reaction mechanism of the inhibition. 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