{"corpus_id":36215327,"paper_sha":"465c92482b2e289af1a85f6f2ae0cb067a469f43","doi":"10.2144/000113401","arxiv_id":null,"pmid":20569203,"pmcid":null,"mag_id":2025064029,"dblp_id":null,"acl_id":null,"title":"High-throughput methods to define complex stem cell niches.","year":2010,"publication_date":"2010-04-01","venue":"BioTechniques","journal":{"name":"BioTechniques","pages":"\n          ix-xxii\n        ","volume":"48 4"},"journal_issn":null,"journal_title":null,"publication_types":["Review","JournalArticle"],"pubmed_pub_types":["Journal Article","Review"],"s2_fields_of_study":["Biology","Medicine"],"reference_count":0,"citation_count":86,"influential_citation_count":0,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Cell Communication","mj":false,"ui":"D002450"},{"d":"Cell Culture Techniques","mj":true,"qs":[{"q":"instrumentation","mj":false,"ui":"Q000295"},{"q":"methods","mj":false,"ui":"Q000379"}],"ui":"D018929"},{"d":"High-Throughput Screening Assays","mj":true,"qs":[{"q":"instrumentation","mj":false,"ui":"Q000295"},{"q":"methods","mj":false,"ui":"Q000379"}],"ui":"D057166"},{"d":"Microfluidic Analytical Techniques","mj":false,"ui":"D046210"},{"d":"Micromanipulation","mj":false,"ui":"D008846"},{"d":"Protein Array Analysis","mj":false,"ui":"D040081"},{"d":"Stem Cells","mj":false,"qs":[{"q":"cytology","mj":false,"ui":"Q000166"},{"q":"physiology","mj":true,"ui":"Q000502"}],"ui":"D013234"}],"chemicals":null,"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"The potential of stem cells in clinics and as a diagnostic tool is still largely unmet, partially due to a lack of in vitro models that efficiently mimic the in vivo stem cell microenvironment-or niche-and thus would allow reproducible propagation of stem cells or their controlled differentiation in vitro. The current methodological challenges in studying and manipulating stem cells have spurred intense development and application of microfabrication and micropatterning technologies in stem cell biology. These approaches can be readily used to dissect the complex molecular interplay of stem cells and their niche and study single-cell behavior in high-throughput. 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