{"corpus_id":36422711,"paper_sha":"3a214f48ac67b5db4d8f3347f367165436e66dea","doi":"10.3109/03009738409179507","arxiv_id":null,"pmid":6516066,"pmcid":null,"mag_id":2114100397,"dblp_id":null,"acl_id":null,"title":"Evaluation of possible spinal neurotoxicity of clonidine.","year":1984,"publication_date":null,"venue":"Upsala Journal of Medical Sciences","journal":{"name":"Upsala journal of medical sciences","pages":"\n          266-73\n        ","volume":"89 3"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, Non-U.S. Gov't"],"s2_fields_of_study":["Medicine"],"reference_count":13,"citation_count":38,"influential_citation_count":0,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Brain","mj":false,"qs":[{"q":"drug effects","mj":false,"ui":"Q000187"},{"q":"pathology","mj":false,"ui":"Q000473"}],"ui":"D001921"},{"d":"Clonidine","mj":false,"qs":[{"q":"toxicity","mj":true,"ui":"Q000633"}],"ui":"D003000"},{"d":"Dogs","mj":false,"ui":"D004285"},{"d":"Female","mj":false,"ui":"D005260"},{"d":"Neurotoxins","mj":true,"ui":"D009498"},{"d":"Organ Specificity","mj":false,"ui":"D009928"},{"d":"Spinal Cord","mj":false,"qs":[{"q":"drug effects","mj":true,"ui":"Q000187"},{"q":"pathology","mj":false,"ui":"Q000473"}],"ui":"D013116"}],"chemicals":[{"n":"Neurotoxins","ui":"D009498","reg":"0"},{"n":"Clonidine","ui":"D003000","reg":"MN3L5RMN02"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://ujms.net/index.php/ujms/article/download/7009/12803","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/3a214f48ac67b5db4d8f3347f367165436e66dea","s2_open_access_license":"CCBY","s2_open_access_status":"HYBRID","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"An experimental investigation was carried out concerning the potential neurotoxic effects of clonidine. For this purpose intrathecal or extradural catheters were implanted in dogs. Clonidine at a dose level of 25 micrograms/kg or 12.5 micrograms/kg, or placebo, was then administrated via the catheter once daily for 14 consecutive days. The spinal cord and the nerve roots were then taken for neuropathological analysis. Observation of the neurological behaviour of the animals and the results of the morphological investigation support the conclusion that clonidine under these circumstances does not have any significant neurotoxic effects.","claims":[{"public_id":"cl_27ed8327a0e6b7af8071d3ad1943b105","status":"active","text":"Clonidine administered intrathecally or extraduraly once daily for 14 days did not produce significant spinal neurotoxic effects under the tested conditions.","confidence":0.97,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_27ed8327a0e6b7af8071d3ad1943b105"},{"public_id":"cl_b821fce5b3163aad1feec27dcfa1f6ec","status":"active","text":"Neurological behavior and neuropathological morphology in dogs supported the absence of significant neurotoxicity after repeated catheter administration of clonidine.","confidence":0.92,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_b821fce5b3163aad1feec27dcfa1f6ec"}],"concepts":[{"public_id":"co_2033ca2425c4b5f2900b78391b327fbc","status":"active","name":"neuropathological analysis","description":"Microscopic and morphological examination of the spinal cord and nerve roots.","types":["analysis method"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_2033ca2425c4b5f2900b78391b327fbc"},{"public_id":"co_2e6924197df26d0e2ec12191e031b4ff","status":"active","name":"clonidine","description":"An alpha-2 adrenergic agonist administered here through spinal catheter 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