{"corpus_id":36950926,"paper_sha":"9a93285755c4fe63c27a4b1e237eda104b5a72f6","doi":"10.4103/0366-6999.183427","arxiv_id":null,"pmid":27270547,"pmcid":"4910375","mag_id":2416055080,"dblp_id":null,"acl_id":null,"title":"Topical Tetracycline Improves MC903-induced Atopic Dermatitis in Mice through Inhibition of Inflammatory Cytokines and Thymic Stromal Lymphopoietin Expression","year":2016,"publication_date":"2016-06-20","venue":"Chinese Medical Journal","journal":{"name":"Chinese Medical Journal","pages":"1483 - 1490","volume":"129"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article"],"s2_fields_of_study":["Medicine"],"reference_count":33,"citation_count":16,"influential_citation_count":0,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Administration, Topical","mj":false,"ui":"D000287"},{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Calcitriol","mj":false,"qs":[{"q":"analogs & derivatives","mj":false,"ui":"Q000031"},{"q":"toxicity","mj":false,"ui":"Q000633"}],"ui":"D002117"},{"d":"Cytokines","mj":false,"ui":"D016207"},{"d":"Dermatitis, Atopic","mj":false,"qs":[{"q":"chemically induced","mj":false,"ui":"Q000139"},{"q":"drug therapy","mj":true,"ui":"Q000188"}],"ui":"D003876"},{"d":"Disease Models, Animal","mj":false,"ui":"D004195"},{"d":"Enzyme-Linked Immunosorbent Assay","mj":false,"ui":"D004797"},{"d":"Female","mj":false,"ui":"D005260"},{"d":"Interleukin-13","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D018793"},{"d":"Interleukin-4","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D015847"},{"d":"Mice","mj":false,"ui":"D051379"},{"d":"Mice, Inbred BALB C","mj":false,"ui":"D008807"},{"d":"Tetracyclines","mj":false,"qs":[{"q":"administration & dosage","mj":false,"ui":"Q000008"},{"q":"therapeutic use","mj":true,"ui":"Q000627"}],"ui":"D013754"},{"d":"Tumor Necrosis Factor-alpha","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D014409"},{"d":"Thymic Stromal Lymphopoietin","mj":false,"ui":"D000094632"}],"chemicals":[{"n":"Cytokines","ui":"D016207","reg":"0"},{"n":"Interleukin-13","ui":"D018793","reg":"0"},{"n":"Tetracyclines","ui":"D013754","reg":"0"},{"n":"Tumor Necrosis Factor-alpha","ui":"D014409","reg":"0"},{"n":"calcipotriene","ui":"C055085","reg":"143NQ3779B"},{"n":"Interleukin-4","ui":"D015847","reg":"207137-56-2"},{"n":"Calcitriol","ui":"D002117","reg":"FXC9231JVH"},{"n":"Thymic Stromal Lymphopoietin","ui":"D000094632","reg":"GT0IL38SP4"},{"n":"TSLP protein, mouse","ui":"C000721967","reg":"0"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Background:Tetracycline (TET) has been found to have both antibiotic and anti-inflammatory properties. The anti-inflammatory effect of topical TET on atopic dermatitis (AD) has not been reported. The purpose of this study was to explore the potential role of topical TET and its anti-inflammatory effects in a mouse model of AD. Methods:The 2% TET was applied topically to ears of MC903-induced AD-like BALB/c mice once a day. AD-like symptoms and severity were evaluated by assessing skin scoring of dermatitis, ear thickness, and frequency of scratching. Serum IgE and thymic stromal lymphopoietin (TSLP) levels were measured by enzyme-linked immunosorbent assay. Western blot was used for analyzing the expressions of TSLP, protease-activated receptor 2 (PAR2), and nuclear factor-kappa B (NF-&kgr;B) in skin lesions. Real-time polymerase chain reaction was performed to assess the mRNA levels of TSLP and inflammatory cytokines including interleukin (IL)-4, IL-13, tumor necrosis factor (TNF)-&agr;, and IL-1&bgr; in skin lesions. Results:Scoring of dermatitis (9.00 ± 0.63 vs. 6.67 ± 1.03, P = 0.001), ear thickness (0.44 ± 0.02 mm vs. 0.40 ± 0.03 mm, P = 0.018), and serum IgE level (421.06 ± 212.13 pg/ml vs. 244.15 ± 121.39 pg/ml, P = 0.047) were all improved in the 2% TET treatment group compared with AD group. Topical TET significantly reduced the serum level of TSLP (119.04 ± 38.92 pg/ml vs. 65.95 ± 54.61 pg/ml, P = 0.011) and both mRNA and protein expressions of TSLP in skin lesions compared with AD group (P = 0.003 and 0.011, respectively), and NF-&kgr;B and PAR2 expression in skin lesions were also suppressed (P = 0.016 and 0.040, respectively). Furthermore, expressions of inflammatory cytokines IL-4, IL-13, and TNF-&agr; in skin lesions were down-regulated in 2% TET group compared with AD group (P = 0.035, 0.008, and 0.044, respectively). Conclusions:Topical TET exerted anti-inflammatory effects through suppression of TSLP and inflammatory cytokines in AD mouse model, suggesting TET as a potential agent for the topical treatment of AD in the future.","claims":[{"public_id":"cl_061dceade4b956a455a8df33e5d34c2f","status":"active","text":"Anti-inflammatory effects in the atopic dermatitis mouse model are associated with suppression of thymic stromal lymphopoietin and inflammatory cytokines.","confidence":0.9,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_061dceade4b956a455a8df33e5d34c2f"},{"public_id":"cl_e8a4bcf6c3a02c1759a3783f10cb5c76","status":"active","text":"Topical 2% tetracycline down-regulated interleukin-4, interleukin-13, tumor necrosis factor-alpha, and interleukin-1 beta expression in skin 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