{"corpus_id":37448366,"paper_sha":"c0ae61f649c2a9ba90e2832a290846172b4743f4","doi":"10.1172/JCI112902","arxiv_id":null,"pmid":3102560,"pmcid":"PMC424237","mag_id":2112348962,"dblp_id":null,"acl_id":null,"title":"Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon.","year":1987,"publication_date":"1987-03-01","venue":"Journal of Clinical Investigation","journal":{"name":"The Journal of clinical investigation","pages":"\n          918-25\n        ","volume":"79 3"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article"],"s2_fields_of_study":["Biology","Medicine"],"reference_count":32,"citation_count":890,"influential_citation_count":10,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Alanine Transaminase","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D000410"},{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Blood Coagulation Disorders","mj":false,"qs":[{"q":"etiology","mj":true,"ui":"Q000209"},{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D001778"},{"d":"Enzyme Activation","mj":false,"ui":"D004789"},{"d":"Escherichia coli","mj":true,"ui":"D004926"},{"d":"Factor V","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D005165"},{"d":"Factor VIII","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D005169"},{"d":"Fibrinogen","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D005340"},{"d":"Leukocyte Count","mj":false,"ui":"D007958"},{"d":"Liver Diseases","mj":false,"qs":[{"q":"etiology","mj":false,"ui":"Q000209"},{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D008107"},{"d":"Papio","mj":false,"ui":"D010215"},{"d":"Protein C","mj":false,"qs":[{"q":"physiology","mj":true,"ui":"Q000502"}],"ui":"D011486"},{"d":"Shock, Septic","mj":false,"qs":[{"q":"complications","mj":true,"ui":"Q000150"},{"q":"prevention & control","mj":false,"ui":"Q000517"}],"ui":"D012772"}],"chemicals":[{"n":"Protein C","ui":"D011486","reg":"0"},{"n":"Factor V","ui":"D005165","reg":"9001-24-5"},{"n":"Factor VIII","ui":"D005169","reg":"9001-27-8"},{"n":"Fibrinogen","ui":"D005340","reg":"9001-32-5"},{"n":"Alanine Transaminase","ui":"D000410","reg":"EC 2.6.1.2"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"http://www.jci.org/articles/view/112902/files/pdf","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/c0ae61f649c2a9ba90e2832a290846172b4743f4","s2_open_access_license":null,"s2_open_access_status":"BRONZE","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Gram-negative septicemia elicits multiple abnormalities of the coagulation system. Although products of coagulation can lead to clot formation, thereby potentiating organ damage, recent work has shown that low concentrations of thrombin can protect animals from the shock state. Because these amounts of thrombin also lead to formation in vivo of the anticoagulant enzyme, activated protein C, we examined the role of protein C in modulation of Escherichia coli shock in baboons. First, we infused activated protein C and lethal concentrations of E. coli organisms, which prevented the coagulopathic, hepatotoxic, and lethal effects of E. coli. Second, using an antibody to protein C we blocked protein C activation in vivo to determine if this influenced the response to lethal and sublethal concentrations of E. coli organisms. Under these conditions the response to lethal concentrations of E. coli organisms was made more severe and the response to sublethal concentrations of E. coli was made lethal. The coagulopathic, hepatotoxic, and lethal responses in this latter case were prevented by infusion of exogenous protein C.","claims":[{"public_id":"cl_95eb8288acfa34a20bf1d42b53ab6c23","status":"active","text":"Activated protein C prevents the coagulopathic, hepatotoxic, and lethal effects of lethal Escherichia coli infusion in baboons.","confidence":0.98,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_95eb8288acfa34a20bf1d42b53ab6c23"},{"public_id":"cl_fcd3211992729eada53a5713700af59f","status":"active","text":"Blocking protein C activation in vivo makes the response to lethal Escherichia coli more severe and converts the response to sublethal Escherichia coli into a lethal one.","confidence":0.96,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_fcd3211992729eada53a5713700af59f"},{"public_id":"cl_12c3522bc22f117c68f9590b92514d9c","status":"active","text":"Exogenous protein C prevents the coagulopathic, hepatotoxic, and lethal responses that follow inhibition of endogenous protein C activation.","confidence":0.95,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_12c3522bc22f117c68f9590b92514d9c"}],"concepts":[{"public_id":"co_0c97b2f114a5f03938654e6055358ee5","status":"active","name":"activated protein C","description":"The activated anticoagulant form of protein C.","types":["protein","anticoagulant enzyme"],"aliases":["APC"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_0c97b2f114a5f03938654e6055358ee5"},{"public_id":"co_17d9dc67f401ada70b3c593f3e9aaea1","status":"active","name":"lethal effects","description":"Fatal outcomes resulting from the septic challenge.","types":["outcome"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_17d9dc67f401ada70b3c593f3e9aaea1"},{"public_id":"co_299ff3ddb6562d296f51fe38e14ad023","status":"active","name":"baboons","description":"Nonhuman primates used as the experimental animal model.","types":["animal model","primate"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_299ff3ddb6562d296f51fe38e14ad023"},{"public_id":"co_54418aa62ff14d6dcf88e3f047cca505","status":"active","name":"Escherichia coli","description":"A gram-negative bacterium used here as the septic challenge organism.","types":["organism","bacterium"],"aliases":["E. coli"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_54418aa62ff14d6dcf88e3f047cca505"},{"public_id":"co_65d9ac98ff69e280cb143b9f2b02f597","status":"active","name":"protein C","description":"A vitamin K-dependent plasma protein that functions in the anticoagulant pathway.","types":["protein"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_65d9ac98ff69e280cb143b9f2b02f597"},{"public_id":"co_b1b670c899f6739341af827c926ea349","status":"active","name":"coagulopathic effects","description":"Disorders of blood coagulation associated with septic challenge.","types":["outcome","pathophysiological effect"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_b1b670c899f6739341af827c926ea349"},{"public_id":"co_c67ddd92a0339763553f648f2677ed66","status":"active","name":"sublethal concentrations of Escherichia coli","description":"An Escherichia coli dose that does not cause death under normal conditions in the experiment.","types":["experimental condition"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_c67ddd92a0339763553f648f2677ed66"},{"public_id":"co_c7c58de4881d15999678a1ad1d96a66f","status":"active","name":"hepatotoxic effects","description":"Liver-damaging effects associated with septic challenge.","types":["outcome","pathophysiological effect"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_c7c58de4881d15999678a1ad1d96a66f"},{"public_id":"co_d49c7743d057d1690b4430fa03491564","status":"active","name":"protein C activation","description":"The conversion of protein C into its activated anticoagulant form in vivo.","types":["biological process"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_d49c7743d057d1690b4430fa03491564"},{"public_id":"co_f29fa8927dbda0664a0ceb4bd0214e19","status":"active","name":"exogenous protein C","description":"Protein C administered from an external source to restore anticoagulant activity.","types":["treatment"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_f29fa8927dbda0664a0ceb4bd0214e19"}],"external_ids":{"DOI":"10.1172/JCI112902","ArXiv":null,"PubMed":3102560,"PubMedCentral":"PMC424237","MAG":2112348962,"DBLP":null,"ACL":null},"open_access":{"is_open_access":true,"pdf_url":"http://www.jci.org/articles/view/112902/files/pdf","landing_url":"https://www.semanticscholar.org/paper/c0ae61f649c2a9ba90e2832a290846172b4743f4","source":"semantic_scholar","pdf_url_source":"semantic_scholar_open_access_pdf","license":null,"status":"BRONZE","reason":null},"reference_availability":{"status":"available","references_indexed":true,"full_text_available":false,"full_text_source":null,"count_basis":"semantic_scholar_metadata","extraction_status":"not_applicable","reason":null},"source":{"provider":"episteme2","base_corpus":"semantic_scholar_dump","freshness_mode":"unknown","basis":["semantic_scholar_metadata","postgres_metadata"],"limits":["paper metadata is based on indexed upstream scholarly datasets","claims and concepts are available only for extracted papers","absence of claims or concepts means no extracted graph data is available in this response"],"status":"available","degraded":false,"degraded_reasons":[],"diagnostics":{"status":"available","degraded":false,"degraded_reasons":[],"metadata_status":"available","graph_status":"available","abstract_status":"available"},"source_flags":5},"paper_id":636072,"paper_uid":"2fc17ee2-cee4-4ef3-b523-d6184c3c4fbe","canonical_identity":{"paper_id":636072,"paper_uid":"2fc17ee2-cee4-4ef3-b523-d6184c3c4fbe","identity_status":"available","lookup_basis":"semantic_scholar_external_id","compatibility_path":"corpus_id"},"url":"https://sah.borca.ai/papers/37448366"}