{"corpus_id":38119879,"paper_sha":"28f36522855301be05753c3939dca314bb1c31e8","doi":"10.1126/science.1228746","arxiv_id":null,"pmid":23065905,"pmcid":null,"mag_id":2050694525,"dblp_id":null,"acl_id":null,"title":"Copy Number Variation of Multiple Genes at Rhg1 Mediates Nematode Resistance in Soybean","year":2012,"publication_date":"2012-11-30","venue":"Science","journal":{"name":"Science","pages":"1206 - 1209","volume":"338"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, Non-U.S. Gov't","Research Support, U.S. Gov't, Non-P.H.S."],"s2_fields_of_study":["Agricultural and Food Sciences","Medicine","Biology","Environmental Science"],"reference_count":50,"citation_count":554,"influential_citation_count":41,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Alleles","mj":false,"ui":"D000483"},{"d":"Amino Acid Sequence","mj":false,"ui":"D000595"},{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Gene Dosage","mj":true,"ui":"D018628"},{"d":"Gene Expression Regulation, Plant","mj":false,"ui":"D018506"},{"d":"Genetic Loci","mj":true,"ui":"D056426"},{"d":"Genetic Variation","mj":false,"ui":"D014644"},{"d":"Haplotypes","mj":false,"ui":"D006239"},{"d":"Male","mj":false,"ui":"D008297"},{"d":"Molecular Sequence Data","mj":false,"ui":"D008969"},{"d":"Plant Diseases","mj":false,"qs":[{"q":"genetics","mj":true,"ui":"Q000235"},{"q":"parasitology","mj":true,"ui":"Q000469"}],"ui":"D010935"},{"d":"Plant Proteins","mj":false,"qs":[{"q":"genetics","mj":true,"ui":"Q000235"}],"ui":"D010940"},{"d":"Plant Roots","mj":false,"qs":[{"q":"genetics","mj":false,"ui":"Q000235"},{"q":"parasitology","mj":false,"ui":"Q000469"}],"ui":"D018517"},{"d":"Protein Structure, Tertiary","mj":false,"qs":[{"q":"genetics","mj":false,"ui":"Q000235"}],"ui":"D017434"},{"d":"Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins","mj":false,"qs":[{"q":"genetics","mj":false,"ui":"Q000235"}],"ui":"D052067"},{"d":"Glycine max","mj":false,"qs":[{"q":"genetics","mj":true,"ui":"Q000235"},{"q":"parasitology","mj":true,"ui":"Q000469"}],"ui":"D013025"},{"d":"Tylenchoidea","mj":true,"ui":"D014431"}],"chemicals":[{"n":"Plant Proteins","ui":"D010940","reg":"0"},{"n":"Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins","ui":"D052067","reg":"0"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://www.science.org/cms/asset/5d00802f-f79d-4914-a04e-12701718d2c9/pap.pdf","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/28f36522855301be05753c3939dca314bb1c31e8","s2_open_access_license":null,"s2_open_access_status":"BRONZE","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"The rhg1-b allele of soybean is widely used for resistance against soybean cyst nematode (SCN), the most economically damaging pathogen of soybeans in the United States. Gene silencing showed that genes in a 31-kilobase segment at rhg1-b, encoding an amino acid transporter, an α-SNAP protein, and a WI12 (wound-inducible domain) protein, each contribute to resistance. There is one copy of the 31-kilobase segment per haploid genome in susceptible varieties, but 10 tandem copies are present in an rhg1-b haplotype. Overexpression of the individual genes in roots was ineffective, but overexpression of the genes together conferred enhanced SCN resistance. Hence, SCN resistance mediated by the soybean quantitative trait locus Rhg1 is conferred by copy number variation that increases the expression of a set of dissimilar genes in a repeated multigene segment.","claims":[{"public_id":"cl_9bb0c2870015fac254871162e0109d44","status":"active","text":"Copy number variation of a 31-kilobase segment at the rhg1-b locus mediates soybean cyst nematode resistance.","confidence":0.95,"contributors":[{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["extraction"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale 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not individually, confers enhanced SCN resistance.","confidence":0.95,"contributors":[{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["extraction"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/claims/cl_61383bc0c9b28e7fb71e570e87dc6479"},{"public_id":"cl_c107bc73e9cf709061053a662b31181e","status":"active","text":"Susceptible soybean varieties have one copy of the 31-kilobase segment per haploid genome, while the rhg1-b haplotype carries 10 tandem copies.","confidence":0.95,"contributors":[{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ 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