{"corpus_id":39523966,"paper_sha":"7104fb23522238dfd49697bc912c6f19bd8b3ac3","doi":"10.1016/s0021-9258(18)98616-3","arxiv_id":null,"pmid":1869554,"pmcid":null,"mag_id":1530113860,"dblp_id":null,"acl_id":null,"title":"RPC19, the gene for a subunit common to yeast RNA polymerases A (I) and C (III).","year":1991,"publication_date":"1991-08-15","venue":"Journal of Biological Chemistry","journal":{"name":"The Journal of biological chemistry","pages":"\n          15300-7\n        ","volume":"266 23"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article"],"s2_fields_of_study":["Biology","Medicine"],"reference_count":0,"citation_count":111,"influential_citation_count":11,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Amino Acid Sequence","mj":false,"ui":"D000595"},{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Base Sequence","mj":false,"ui":"D001483"},{"d":"Blotting, Southern","mj":false,"ui":"D015139"},{"d":"Chromosome Mapping","mj":false,"ui":"D002874"},{"d":"DNA, Fungal","mj":false,"qs":[{"q":"analysis","mj":false,"ui":"Q000032"}],"ui":"D004271"},{"d":"Escherichia coli","mj":false,"ui":"D004926"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Molecular Sequence Data","mj":false,"ui":"D008969"},{"d":"Open Reading Frames","mj":false,"ui":"D016366"},{"d":"Plasmids","mj":false,"ui":"D010957"},{"d":"RNA Polymerase I","mj":false,"qs":[{"q":"genetics","mj":true,"ui":"Q000235"}],"ui":"D012318"},{"d":"RNA Polymerase III","mj":false,"qs":[{"q":"genetics","mj":true,"ui":"Q000235"}],"ui":"D012320"},{"d":"Restriction Mapping","mj":false,"ui":"D015183"},{"d":"Saccharomyces cerevisiae","mj":false,"qs":[{"q":"enzymology","mj":false,"ui":"Q000201"},{"q":"genetics","mj":true,"ui":"Q000235"}],"ui":"D012441"},{"d":"Sequence Homology, Nucleic Acid","mj":false,"ui":"D012689"},{"d":"Tetrahymena","mj":false,"ui":"D013768"}],"chemicals":[{"n":"DNA, Fungal","ui":"D004271","reg":"0"},{"n":"RNA Polymerase I","ui":"D012318","reg":"EC 2.7.7.6"},{"n":"RNA Polymerase III","ui":"D012320","reg":"EC 2.7.7.6"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Yeast RNA polymerases A (I) and C (III) share a subunit called AC19. The gene encoding AC19 has been isolated from yeast genomic DNA using oligonucleotide probes deduced from peptide sequences of the isolated subunit. This gene (RPC19) contains an intron-free open reading frame of 143 amino acid residues. RPC19 is a single copy gene that maps on chromosome II and is essential for cell viability. The amino acid sequence contains a sequence motif common to the Escherichia coli RNA polymerase alpha subunit, the Saccharomyces cerevisiae AC40 and B44.5 subunits, the human hRPB33 product, and the CnjC conjugation-specific gene product of Tetrahymena. The 5'-upstream region contains a sequence element, the PAC box, that has been conserved in at least 10 genes encoding subunits of RNA polymerases A and C.","claims":[{"public_id":"cl_c3f85f43b2ca6e52dff2564a692f4fcd","status":"active","text":"RPC19 contains an intron-free open reading frame of 143 amino acid residues and is a single-copy gene mapped to chromosome II.","confidence":0.97,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_c3f85f43b2ca6e52dff2564a692f4fcd"},{"public_id":"cl_98a111547684b93aa9421d1c05545113","status":"active","text":"RPC19 encodes the yeast RNA polymerase subunit AC19 shared by RNA polymerases A (I) and C (III).","confidence":0.99,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_98a111547684b93aa9421d1c05545113"},{"public_id":"cl_5126c62c27d323c7967f42fa6b689ca4","status":"active","text":"RPC19 is essential for cell viability.","confidence":0.98,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_5126c62c27d323c7967f42fa6b689ca4"},{"public_id":"cl_bb87773f3d63acb5686d9976aab68e1d","status":"active","text":"The 5'-upstream region contains the PAC box, a conserved sequence element found in at least 10 genes encoding subunits of RNA polymerases A and C.","confidence":0.96,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_bb87773f3d63acb5686d9976aab68e1d"},{"public_id":"cl_87438fa13fd7809985599839ea72b9c2","status":"active","text":"The encoded protein contains a motif shared with the Escherichia coli RNA polymerase alpha subunit, Saccharomyces cerevisiae AC40 and B44.5 subunits, the human hRPB33 product, and the Tetrahymena CnjC gene product.","confidence":0.95,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_87438fa13fd7809985599839ea72b9c2"}],"concepts":[{"public_id":"co_1af176a8ada10c12b65bc9e1789a2049","status":"active","name":"chromosome II","description":"The yeast chromosome on which RPC19 is mapped.","types":["chromosome"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_1af176a8ada10c12b65bc9e1789a2049"},{"public_id":"co_2e333b1e28483e2e0989518b263c3e03","status":"active","name":"Escherichia coli RNA polymerase alpha subunit","description":"The alpha subunit of the bacterial RNA polymerase from Escherichia coli.","types":["protein subunit"],"aliases":["E. coli RNA polymerase alpha subunit"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_2e333b1e28483e2e0989518b263c3e03"},{"public_id":"co_35db4394028565d988f93e0586912f09","status":"active","name":"human hRPB33 product","description":"A human gene product mentioned as sharing the conserved amino acid motif.","types":["protein"],"aliases":["hRPB33"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_35db4394028565d988f93e0586912f09"},{"public_id":"co_36340b309f00c00bfb625f30d7507d1a","status":"active","name":"RNA polymerase A and C subunit genes","description":"Genes encoding subunits of RNA polymerases A and C that share the PAC box element.","types":["gene set"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_36340b309f00c00bfb625f30d7507d1a"},{"public_id":"co_3ebc78c7936d58f3725db184cb1df5a5","status":"active","name":"motif common to RNA polymerase and related proteins","description":"A shared amino acid sequence motif present in multiple RNA polymerase-associated proteins.","types":["sequence motif"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_3ebc78c7936d58f3725db184cb1df5a5"},{"public_id":"co_490ae9778124b30fda026b3dd26ddd0e","status":"active","name":"yeast RNA polymerases A (I) and C (III)","description":"Two yeast RNA polymerase complexes that share the AC19 subunit.","types":["protein complex"],"aliases":["RNA polymerases A (I) and C (III)"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_490ae9778124b30fda026b3dd26ddd0e"},{"public_id":"co_4b0db2154ae3d9b6ca486e99287967c0","status":"active","name":"AC19","description":"A subunit shared by yeast RNA polymerases A (I) and C (III).","types":["protein subunit"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_4b0db2154ae3d9b6ca486e99287967c0"},{"public_id":"co_53e016ce34f090f3ad372f88a3562698","status":"active","name":"PAC box","description":"A conserved sequence element present in upstream regions of multiple RNA polymerase subunit genes.","types":["sequence element"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_53e016ce34f090f3ad372f88a3562698"},{"public_id":"co_6c3c3cc26291e1713c8e4026ee9ac4c8","status":"active","name":"RPC19","description":"The yeast gene identified in this study that encodes the AC19 RNA polymerase subunit.","types":["gene"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_6c3c3cc26291e1713c8e4026ee9ac4c8"},{"public_id":"co_9ceaf33484d17010681b23b5343884ee","status":"active","name":"5'-upstream region","description":"The promoter-proximal DNA region upstream of the RPC19 coding sequence.","types":["genomic region"],"aliases":["5-prime upstream region"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_9ceaf33484d17010681b23b5343884ee"},{"public_id":"co_aac227998cc118460dc3e9ceb4f2567f","status":"active","name":"cell viability","description":"The ability of yeast cells to survive and grow.","types":["phenotype"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_aac227998cc118460dc3e9ceb4f2567f"},{"public_id":"co_f7f10e02127b43fff3c2073cf6083ece","status":"active","name":"open reading frame of 143 amino acid residues","description":"The intron-free protein-coding sequence encoded by RPC19.","types":["genetic element"],"aliases":["143 amino acid residues ORF"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_f7f10e02127b43fff3c2073cf6083ece"}],"external_ids":{"DOI":"10.1016/s0021-9258(18)98616-3","ArXiv":null,"PubMed":1869554,"PubMedCentral":null,"MAG":1530113860,"DBLP":null,"ACL":null},"open_access":{"is_open_access":false,"pdf_url":null,"landing_url":"https://sah.borca.ai/papers/39523966","source":null,"pdf_url_source":null,"license":null,"reason":"pdf_url_not_indexed"},"reference_availability":{"status":"unknown","references_indexed":false,"full_text_available":false,"full_text_source":null,"count_basis":"semantic_scholar_metadata","extraction_status":"not_applicable","reason":null},"source":{"provider":"episteme2","base_corpus":"semantic_scholar_dump","freshness_mode":"unknown","basis":["semantic_scholar_metadata","postgres_metadata"],"limits":["paper metadata is based on indexed upstream scholarly datasets","claims and concepts are available only for extracted papers","absence of claims or concepts means no extracted graph data is available in this response"],"status":"available","degraded":false,"degraded_reasons":[],"diagnostics":{"status":"available","degraded":false,"degraded_reasons":[],"metadata_status":"available","graph_status":"available","abstract_status":"available"},"source_flags":5},"paper_id":638490,"paper_uid":"e40105ce-fabe-4abd-ae84-41f2396aa0a8","canonical_identity":{"paper_id":638490,"paper_uid":"e40105ce-fabe-4abd-ae84-41f2396aa0a8","identity_status":"available","lookup_basis":"semantic_scholar_external_id","compatibility_path":"corpus_id"},"url":"https://sah.borca.ai/papers/39523966"}