{"corpus_id":39875172,"paper_sha":"26fd6d4e71bc21324e2ab2aeeec3a1e35961bb56","doi":"10.2460/ajvr.1996.57.04.522","arxiv_id":null,"pmid":8712518,"pmcid":null,"mag_id":18210461,"dblp_id":null,"acl_id":null,"title":"Evaluation of injections of collagenase and oxytetracycline via the umbilical artery as treatment for retained placenta in cattle.","year":1996,"publication_date":"1996-04-01","venue":"American Journal of Veterinary Research","journal":{"name":"American journal of veterinary research","pages":"\n          522-5\n        ","volume":"57 4"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle","ClinicalTrial"],"pubmed_pub_types":["Clinical Trial","Controlled Clinical Trial","Journal Article","Research Support, Non-U.S. Gov't"],"s2_fields_of_study":["Agricultural and Food Sciences","Medicine","Chemistry"],"reference_count":0,"citation_count":9,"influential_citation_count":0,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Anti-Bacterial Agents","mj":false,"qs":[{"q":"administration & dosage","mj":false,"ui":"Q000008"},{"q":"pharmacokinetics","mj":false,"ui":"Q000493"},{"q":"therapeutic use","mj":true,"ui":"Q000627"}],"ui":"D000900"},{"d":"Cattle","mj":false,"ui":"D002417"},{"d":"Cattle Diseases","mj":true,"ui":"D002418"},{"d":"Clostridium","mj":false,"ui":"D003013"},{"d":"Collagenases","mj":false,"qs":[{"q":"administration & dosage","mj":false,"ui":"Q000008"},{"q":"therapeutic use","mj":true,"ui":"Q000627"}],"ui":"D017364"},{"d":"Drug Therapy, Combination","mj":false,"ui":"D004359"},{"d":"Female","mj":false,"ui":"D005260"},{"d":"Injections, Intra-Arterial","mj":false,"ui":"D007269"},{"d":"Manometry","mj":false,"ui":"D008365"},{"d":"Milk","mj":false,"qs":[{"q":"chemistry","mj":false,"ui":"Q000737"}],"ui":"D008892"},{"d":"Oxytetracycline","mj":false,"qs":[{"q":"administration & dosage","mj":false,"ui":"Q000008"},{"q":"pharmacokinetics","mj":false,"ui":"Q000493"},{"q":"therapeutic use","mj":true,"ui":"Q000627"}],"ui":"D010118"},{"d":"Placenta, Retained","mj":false,"qs":[{"q":"drug therapy","mj":false,"ui":"Q000188"},{"q":"veterinary","mj":true,"ui":"Q000662"}],"ui":"D018457"},{"d":"Pregnancy","mj":false,"ui":"D011247"},{"d":"Pressure","mj":false,"ui":"D011312"},{"d":"Probability","mj":false,"ui":"D011336"},{"d":"Prospective Studies","mj":false,"ui":"D011446"},{"d":"Reproducibility of Results","mj":false,"ui":"D015203"},{"d":"Umbilical Arteries","mj":false,"ui":"D014469"}],"chemicals":[{"n":"Anti-Bacterial Agents","ui":"D000900","reg":"0"},{"n":"Collagenases","ui":"D017364","reg":"EC 3.4.24.-"},{"n":"Oxytetracycline","ui":"D010118","reg":"X20I9EN955"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://avmajournals.avma.org/downloadpdf/view/journals/ajvr/57/4/ajvr.1996.57.04.522.pdf","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/26fd6d4e71bc21324e2ab2aeeec3a1e35961bb56","s2_open_access_license":null,"s2_open_access_status":"BRONZE","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"OBJECTIVES\nTo test whether oxytetracycline inactivates collagenase when combined as a potential treatment for retained fetal membranes in cattle and to determine whether oxytetracycline passes to blood from fetal membranes after intraplacental injection.\n\n\nDESIGN\nProspective, controlled study.\n\n\nSAMPLE POPULATION\n288 placentomes from 12 cows in their third trimester of pregnancy and 4 cows at term pregnancy.\n\n\nPROCEDURE\n8 experimental groups were established: saline control, collagenase, collagenase plus oxytetracycline at 3 dosages, and oxytetracycline at 3 dosages. Placentomes were infused through an umbilical vessel with the test solutions and incubated at 39 C for 4 hours. Immediately after incubation, the force needed to detach cotyledons from caruncles was measured by a manometric technique. Cotyledon-caruncle interface fluids were analyzed for hydroxyproline (collagen breakdown) and total protein contents. A combination of collagenase and oxytetracycline was injected via umbilical arteries of cows undergoing cesarean section and in cows with retained fetal membranes after natural delivery. Antibiotic residue in blood was determined by the Bacillus stearothermophilus disk assay.\n\n\nRESULTS\nThere were no significant differences among collagenase and collagenase plus oxytetracycline groups in the amount of pressure needed to separate cotyledon from caruncle, amount of hydroxyproline released, and amount of total protein broken down. The 4 cows tested negative for oxytetracycline in the blood.\n\n\nCLINICAL RELEVANCE\nOxytetracycline and collagenase may be a potential combination treatment for retained fetal membranes in cattle. In addition, the lack of antibiotic residue detection in blood may be of regulatory relevance.","claims":[{"public_id":"cl_621a1d6286224009b909ffefec9758fd","status":"active","text":"After intraplacental injection of oxytetracycline, no antibiotic residue was detected in the blood of cows.","confidence":0.95,"contributors":[{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["extraction"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"}],"url":"https://sah.borca.ai/claims/cl_621a1d6286224009b909ffefec9758fd"},{"public_id":"cl_8e3dc298279cafeaa944024aba2109ba","status":"active","text":"Oxytetracycline and collagenase may be a potential combination treatment for retained fetal membranes in cattle.","confidence":0.8,"contributors":[{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["extraction"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"}],"url":"https://sah.borca.ai/claims/cl_8e3dc298279cafeaa944024aba2109ba"},{"public_id":"cl_82d3e92ae380a11d9eaf0ebbfc963559","status":"active","text":"Oxytetracycline does not inactivate collagenase when combined as a potential treatment for retained fetal membranes in cattle.","confidence":0.9,"contributors":[{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["extraction"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"}],"url":"https://sah.borca.ai/claims/cl_82d3e92ae380a11d9eaf0ebbfc963559"}],"concepts":[{"public_id":"co_1aba6f5bb7f51b3fe365b5a6105c4149","status":"active","name":"intraplacental injection","description":"Injection of test solutions into placentomes via the umbilical artery.","types":["administration route"],"aliases":["umbilical artery injection"],"contributors":[{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["extraction"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"}],"url":"https://sah.borca.ai/concepts/co_1aba6f5bb7f51b3fe365b5a6105c4149"},{"public_id":"co_46da8243a0162a5281895503fa7a01a7","status":"active","name":"collagenase","description":"A proteolytic enzyme used in the experimental treatment for retained fetal membranes in cattle.","types":["enzyme","treatment"],"aliases":[],"contributors":[{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["extraction"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"}],"url":"https://sah.borca.ai/concepts/co_46da8243a0162a5281895503fa7a01a7"},{"public_id":"co_4d5b6acf667078bfda7642b9aee78b82","status":"active","name":"retained fetal membranes","description":"The condition of retained placenta in cattle, targeted by the proposed treatment.","types":["condition"],"aliases":["retained placenta in cattle"],"contributors":[{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["extraction"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"}],"url":"https://sah.borca.ai/concepts/co_4d5b6acf667078bfda7642b9aee78b82"},{"public_id":"co_6cb0e09aa33815603381f19c6f3fb599","status":"active","name":"placentomes","description":"Fetal-maternal contact units used as experimental models in the study.","types":["anatomical structure"],"aliases":[],"contributors":[{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["extraction"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"}],"url":"https://sah.borca.ai/concepts/co_6cb0e09aa33815603381f19c6f3fb599"},{"public_id":"co_95f521665d6dfec877e4b39e062aed91","status":"active","name":"hydroxyproline","description":"A marker of collagen breakdown measured at the cotyledon-caruncle interface.","types":["biomarker"],"aliases":[],"contributors":[{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["extraction"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"}],"url":"https://sah.borca.ai/concepts/co_95f521665d6dfec877e4b39e062aed91"},{"public_id":"co_a7db69ad4a945d7cc9f87abee43f3fe3","status":"active","name":"cotyledon-caruncle interface","description":"The interface between fetal cotyledon and maternal caruncle where separation force and fluid analysis were performed.","types":["interface","measurement site"],"aliases":[],"contributors":[{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["extraction"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"}],"url":"https://sah.borca.ai/concepts/co_a7db69ad4a945d7cc9f87abee43f3fe3"},{"public_id":"co_ad2ce1769c31e43b1b8c767c550012f6","status":"active","name":"Bacillus stearothermophilus disk assay","description":"A microbiological disk assay used to detect oxytetracycline in blood samples.","types":["assay"],"aliases":["disk assay"],"contributors":[{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["extraction"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"}],"url":"https://sah.borca.ai/concepts/co_ad2ce1769c31e43b1b8c767c550012f6"},{"public_id":"co_db030ff98d696cb1c53d0399e488408b","status":"active","name":"antibiotic residue in blood","description":"Detection of oxytetracycline in blood serum using a disk assay.","types":["measurement","outcome"],"aliases":["oxytetracycline blood residue"],"contributors":[{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["extraction"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"}],"url":"https://sah.borca.ai/concepts/co_db030ff98d696cb1c53d0399e488408b"},{"public_id":"co_dcacb236bace0f732aad9692e59bde7a","status":"active","name":"oxytetracycline","description":"An antibiotic tested alone and combined with collagenase for treatment of retained fetal membranes.","types":["antibiotic","treatment"],"aliases":[],"contributors":[{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["extraction"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"}],"url":"https://sah.borca.ai/concepts/co_dcacb236bace0f732aad9692e59bde7a"},{"public_id":"co_e256d532087053cd87bd52b9bfef959d","status":"active","name":"total protein","description":"Total protein content measured in fluids at the cotyledon-caruncle interface.","types":["measurement"],"aliases":[],"contributors":[{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["extraction"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"}],"url":"https://sah.borca.ai/concepts/co_e256d532087053cd87bd52b9bfef959d"}],"external_ids":{"DOI":"10.2460/ajvr.1996.57.04.522","ArXiv":null,"PubMed":8712518,"PubMedCentral":null,"MAG":18210461,"DBLP":null,"ACL":null},"open_access":{"is_open_access":true,"pdf_url":"https://avmajournals.avma.org/downloadpdf/view/journals/ajvr/57/4/ajvr.1996.57.04.522.pdf","landing_url":"https://www.semanticscholar.org/paper/26fd6d4e71bc21324e2ab2aeeec3a1e35961bb56","source":"semantic_scholar","pdf_url_source":"semantic_scholar_open_access_pdf","license":null,"status":"BRONZE","reason":null},"reference_availability":{"status":"unknown","references_indexed":false,"full_text_available":false,"full_text_source":null,"count_basis":"semantic_scholar_metadata","extraction_status":"not_applicable","reason":null},"source":{"provider":"episteme2","base_corpus":"semantic_scholar_dump","freshness_mode":"unknown","basis":["semantic_scholar_metadata","postgres_metadata"],"limits":["paper metadata is based on indexed upstream scholarly datasets","claims and concepts are available only for extracted papers","absence of claims or concepts means no extracted graph data is available in this response"],"status":"available","degraded":false,"degraded_reasons":[],"diagnostics":{"status":"available","degraded":false,"degraded_reasons":[],"metadata_status":"available","graph_status":"available","abstract_status":"available"},"source_flags":5},"paper_id":631009,"paper_uid":"5257f518-cfe8-4b14-bb48-1db0da74a454","canonical_identity":{"paper_id":631009,"paper_uid":"5257f518-cfe8-4b14-bb48-1db0da74a454","identity_status":"available","lookup_basis":"semantic_scholar_external_id","compatibility_path":"corpus_id"},"url":"https://sah.borca.ai/papers/39875172"}