{"corpus_id":39942103,"paper_sha":"950f06e557e31276147ed3089fe0347563f39f19","doi":"10.1021/OL050511W","arxiv_id":null,"pmid":15901156,"pmcid":"PMC1480406","mag_id":1977847221,"dblp_id":null,"acl_id":null,"title":"Synthetic studies on the bryostatins: preparation of a truncated BC-ring intermediate by pyran annulation.","year":2005,"publication_date":"2005-05-26","venue":"Organic Letters","journal":{"name":"Organic letters","pages":"\n          2149-52\n        ","volume":"7 11"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, N.I.H., Extramural","Research Support, U.S. Gov't, P.H.S."],"s2_fields_of_study":["Medicine","Chemistry"],"reference_count":20,"citation_count":39,"influential_citation_count":0,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Antineoplastic Agents","mj":false,"qs":[{"q":"chemical synthesis","mj":true,"ui":"Q000138"},{"q":"chemistry","mj":true,"ui":"Q000737"}],"ui":"D000970"},{"d":"Bryostatins","mj":false,"ui":"D054713"},{"d":"Catalysis","mj":false,"ui":"D002384"},{"d":"Macrolides","mj":false,"qs":[{"q":"chemical synthesis","mj":true,"ui":"Q000138"},{"q":"chemistry","mj":true,"ui":"Q000737"}],"ui":"D018942"},{"d":"Molecular Structure","mj":false,"ui":"D015394"},{"d":"Pyrans","mj":false,"qs":[{"q":"chemistry","mj":true,"ui":"Q000737"}],"ui":"D011714"}],"chemicals":[{"n":"Antineoplastic Agents","ui":"D000970","reg":"0"},{"n":"Bryostatins","ui":"D054713","reg":"0"},{"n":"Macrolides","ui":"D018942","reg":"0"},{"n":"Pyrans","ui":"D011714","reg":"0"},{"n":"bryostatin 1","ui":"C046785","reg":"37O2X55Y9E"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://figshare.com/articles/journal_contribution/Synthetic_Studies_on_the_Bryostatins_Preparation_of_a_Truncated_BC_Ring_Intermediate_by_Pyran_Annulation/3284710/1/files/5122450.pdf","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/950f06e557e31276147ed3089fe0347563f39f19","s2_open_access_license":"CCBYNC","s2_open_access_status":"GREEN","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"[reaction: see text]. A synthesis of a potential BC-ring subunit (C9-C27) for bryostatin 1, a remarkably potent anticancer agent, has been developed in 16 steps and 18% overall yield. 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