{"corpus_id":4203568,"paper_sha":"d95f8aa46a7a1e9d2ee7ac3eec9617b7bfe79c5d","doi":"10.18632/oncotarget.16959","arxiv_id":null,"pmid":28454102,"pmcid":"5514915","mag_id":2605018548,"dblp_id":null,"acl_id":null,"title":"An inverse association between tea consumption and colorectal cancer risk","year":2017,"publication_date":"2017-04-08","venue":"OncoTarget","journal":{"name":"Oncotarget","pages":"37367 - 37376","volume":"8"},"journal_issn":null,"journal_title":null,"publication_types":["MetaAnalysis","JournalArticle"],"pubmed_pub_types":["Journal Article","Meta-Analysis"],"s2_fields_of_study":["Medicine"],"reference_count":59,"citation_count":47,"influential_citation_count":4,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"China","mj":false,"qs":[{"q":"epidemiology","mj":false,"ui":"Q000453"}],"ui":"D002681"},{"d":"Colonic Neoplasms","mj":false,"qs":[{"q":"epidemiology","mj":true,"ui":"Q000453"},{"q":"prevention & control","mj":false,"ui":"Q000517"}],"ui":"D003110"},{"d":"Colorectal Neoplasms","mj":false,"qs":[{"q":"epidemiology","mj":true,"ui":"Q000453"},{"q":"prevention & control","mj":false,"ui":"Q000517"}],"ui":"D015179"},{"d":"Eating","mj":false,"ui":"D004435"},{"d":"Female","mj":false,"ui":"D005260"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Male","mj":false,"ui":"D008297"},{"d":"Odds Ratio","mj":false,"ui":"D016017"},{"d":"Plant Extracts","mj":false,"qs":[{"q":"administration & dosage","mj":false,"ui":"Q000008"}],"ui":"D010936"},{"d":"Risk","mj":false,"ui":"D012306"},{"d":"Sex Factors","mj":false,"ui":"D012737"},{"d":"Tea","mj":true,"ui":"D013662"}],"chemicals":[{"n":"Plant Extracts","ui":"D010936","reg":"0"},{"n":"Tea","ui":"D013662","reg":"0"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=16959&path%5B%5D=54265","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/d95f8aa46a7a1e9d2ee7ac3eec9617b7bfe79c5d","s2_open_access_license":"CCBY","s2_open_access_status":"GOLD","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"It is well known that the tea extracts, mainly polyphenols as chemo-preventive elements, could act as cancer progression blockers. Although the association between tea consumption and colorectal cancer risk has been widely investigated, the results still remain inconsistent. We conducted a dose-response meta-analysis to evaluate their relationships by enrolling qualified 29 literatures. The summary odds ratio (OR) of colorectal cancer for the highest vs. lowest tea consumption was 0.93 with 0.87–1.00 of 95% confidence intervals (CIs) among all studies with modest heterogeneity (P = 0.001, I2 = 43.4%). Stratified analysis revealed that tea, especially green tea, had a protective effect among female and rectal cancer patients. Particularly, the dose-response analysis showed that there was a significant inverse association between an increment of 1 cup/day of tea consumption and colorectal cancer risk in the subgroup of the green tea drinking (OR = 0.98, 95% CI = 0.96–1.01, Pnonlinear = 0.003) and female (OR = 0.68, 95% CI = 0.56-0.81, Pnonlinear < 0.001). Our findings indicate that tea consumption has an inverse impact on colorectal cancer risk, which may have significant public health implications in the prevention of colorectal cancer and further similar researches.","claims":[{"public_id":"cl_77f10606771ff584f04e916bece8025a","status":"active","text":"Each 1 cup/day increment in green tea consumption is inversely associated with colorectal cancer risk (OR = 0.98, 95% CI 0.96–1.01, Pnonlinear = 0.003).","confidence":0.8,"contributors":[{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["extraction"],"url":"https://sah.borca.ai/u/322360f1c1"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ 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