{"corpus_id":42063104,"paper_sha":"59c89998ccb7c1b70b8f7f38c7c534256caa89d9","doi":"10.1006/VIRO.2001.0949","arxiv_id":null,"pmid":11437658,"pmcid":null,"mag_id":2012082229,"dblp_id":null,"acl_id":null,"title":"Identification of dna components required for induction of cotton leaf curl disease.","year":2001,"publication_date":"2001-07-05","venue":"Virology","journal":{"name":"Virology","pages":"\n          234-43\n        ","volume":"285 2"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, Non-U.S. Gov't"],"s2_fields_of_study":["Biology","Medicine","Environmental Science"],"reference_count":32,"citation_count":500,"influential_citation_count":42,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Base Sequence","mj":false,"ui":"D001483"},{"d":"DNA, Circular","mj":false,"ui":"D004270"},{"d":"DNA, Viral","mj":false,"qs":[{"q":"physiology","mj":true,"ui":"Q000502"}],"ui":"D004279"},{"d":"Geminiviridae","mj":false,"qs":[{"q":"genetics","mj":true,"ui":"Q000235"},{"q":"physiology","mj":false,"ui":"Q000502"}],"ui":"D017791"},{"d":"Gossypium","mj":false,"qs":[{"q":"virology","mj":true,"ui":"Q000821"}],"ui":"D003368"},{"d":"Molecular Sequence Data","mj":false,"ui":"D008969"},{"d":"Plant Diseases","mj":false,"qs":[{"q":"virology","mj":false,"ui":"Q000821"}],"ui":"D010935"},{"d":"Sequence Analysis, DNA","mj":false,"ui":"D017422"}],"chemicals":[{"n":"DNA, Circular","ui":"D004270","reg":"0"},{"n":"DNA, Viral","ui":"D004279","reg":"0"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Cotton leaf curl disease (CLCuD) is a major constraint to cotton production in Pakistan. Infectious clones of the monopartite begomovirus cotton leaf curl virus (CLCuV), associated with diseased cotton, are unable to induce typical symptoms in host plants. We have identified and isolated a single-stranded DNA molecule approximately 1350 nucleotides in length which, when coinoculated with the begomovirus to cotton, induces symptoms typical of CLCuD, including vein swelling, vein darkening, leaf curling, and enations. This molecule (termed DNA beta) requires the begomovirus for replication and encapsidation. The CLCuV/DNA 1/DNA beta complex, together with a similar complex previously identified in Ageratum conyzoides, represent members of an entirely new type of infectious, disease-causing agents. The implications of this finding to our understanding of the evolution of new disease-causing agents are discussed.","claims":[{"public_id":"cl_2a050862ba5285cd5c1f972944aefa40","status":"active","text":"A single-stranded DNA molecule of approximately 1350 nucleotides, termed DNA beta, when coinoculated with the monopartite begomovirus cotton leaf curl virus (CLCuV), induces symptoms typical of cotton leaf curl disease, including vein swelling, vein darkening, leaf curling, and enations.","confidence":0.95,"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":127,"public_id":"yy3835ars5","public_label":"Anonymous 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conyzoides, represents members of an entirely new type of infectious, disease-causing agents.","confidence":0.85,"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"},{"id":127,"public_id":"yy3835ars5","public_label":"Anonymous (yy3835ars5)","roles":["review"],"url":"https://sah.borca.ai/u/yy3835ars5"}],"url":"https://sah.borca.ai/claims/cl_b3117280bf476147db1b3b59d0ca4089"}],"concepts":[{"public_id":"co_0830ebf544780681c0859881c7f2ca06","status":"active","name":"cotton leaf curl disease","description":"A major constraint to cotton production in Pakistan, characterized by symptoms including vein swelling, vein darkening, leaf curling, and 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