{"corpus_id":42161758,"paper_sha":"f9ab5c2df3b1653bc38e9e72d7e83599b3b6ccca","doi":"10.2460/ajvr.1981.42.04.629","arxiv_id":null,"pmid":7332124,"pmcid":null,"mag_id":2465444702,"dblp_id":null,"acl_id":null,"title":"Aqueous procaine penicillin G in the horse: serum, synovial, peritoneal, and urine concentrations after single-dose intramuscular administration.","year":1981,"publication_date":"1981-04-01","venue":"American Journal of Veterinary Research","journal":{"name":"American journal of veterinary research","pages":"\n          629-31\n        ","volume":"42 4"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, Non-U.S. Gov't"],"s2_fields_of_study":["Medicine","Chemistry"],"reference_count":0,"citation_count":22,"influential_citation_count":0,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Ascitic Fluid","mj":false,"qs":[{"q":"analysis","mj":true,"ui":"Q000032"}],"ui":"D001202"},{"d":"Female","mj":false,"ui":"D005260"},{"d":"Horses","mj":false,"qs":[{"q":"blood","mj":false,"ui":"Q000097"},{"q":"metabolism","mj":true,"ui":"Q000378"},{"q":"urine","mj":false,"ui":"Q000652"}],"ui":"D006736"},{"d":"Injections, Intramuscular","mj":false,"qs":[{"q":"veterinary","mj":false,"ui":"Q000662"}],"ui":"D007273"},{"d":"Penicillin G Procaine","mj":false,"qs":[{"q":"analysis","mj":true,"ui":"Q000032"},{"q":"blood","mj":false,"ui":"Q000097"},{"q":"urine","mj":false,"ui":"Q000652"}],"ui":"D010402"},{"d":"Synovial Fluid","mj":false,"qs":[{"q":"analysis","mj":true,"ui":"Q000032"}],"ui":"D013582"}],"chemicals":[{"n":"Penicillin G Procaine","ui":"D010402","reg":"17R794ESYN"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Six adult mares were given a single dose of aqueous suspension procaine penicillin G (300,000 IU/ml) IM at a dosage of 22,000 IU/kg of body weight (15.4 mg of penicillin G/kg). Serum, synovial fluid, peritoneal fluid, and urine penicillin concentrations were measured serially over a 48-hour period. The mean peak serum penicillin concentration was 1.42 microgram/ml at 3 hours. Penicillin was detected in synovial fluid and peritoneal fluid, which obtained mean peak penicillin concentrations of 0.62 microgram/ml and 0.58 microgram/ml, at 4 hours and 3 hours, respectively. These concentrations steadily decreased in parallel with serum concentrations and were still measurable at 48 hours. Urine concentrations of penicillin were relatively high, with a mean peak concentration of 525.81 microgram/ml at 8 hours.","claims":[{"public_id":"cl_8986f6359615c025c06a5efe841d782c","status":"active","text":"Mean peak penicillin concentrations in synovial fluid and peritoneal fluid were 0.62 microgram/ml at 4 hours and 0.58 microgram/ml at 3 hours, respectively.","confidence":0.99,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_8986f6359615c025c06a5efe841d782c"},{"public_id":"cl_fa7d013ed8da4dd8e13a265327654cc7","status":"active","text":"Mean peak serum penicillin concentration reached 1.42 microgram/ml at 3 hours after administration.","confidence":0.99,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous 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