{"corpus_id":4312285,"paper_sha":"bd0f80add71db1018d47d832d98e40b1b342ad6b","doi":"10.1093/molbev/msx140","arxiv_id":null,"pmid":28444389,"pmcid":"5850712","mag_id":2403973474,"dblp_id":null,"acl_id":null,"title":"SmithRNAs: Could Mitochondria “Bend” Nuclear Regulation?","year":2017,"publication_date":"2017-04-21","venue":"Molecular biology and evolution","journal":{"name":"Molecular Biology and Evolution","pages":"1960 - 1973","volume":"34"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, Non-U.S. Gov't"],"s2_fields_of_study":["Biology","Medicine"],"reference_count":102,"citation_count":50,"influential_citation_count":1,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Base Sequence","mj":false,"ui":"D001483"},{"d":"Bivalvia","mj":false,"qs":[{"q":"genetics","mj":true,"ui":"Q000235"}],"ui":"D049872"},{"d":"DNA, Mitochondrial","mj":false,"qs":[{"q":"genetics","mj":false,"ui":"Q000235"}],"ui":"D004272"},{"d":"Gene Expression Regulation","mj":false,"ui":"D005786"},{"d":"Genes, Mitochondrial","mj":false,"qs":[{"q":"genetics","mj":false,"ui":"Q000235"}],"ui":"D050259"},{"d":"Genome, Mitochondrial","mj":false,"qs":[{"q":"genetics","mj":false,"ui":"Q000235"}],"ui":"D054629"},{"d":"Gonads","mj":false,"ui":"D006066"},{"d":"Inheritance Patterns","mj":false,"qs":[{"q":"genetics","mj":false,"ui":"Q000235"}],"ui":"D040582"},{"d":"Mitochondria","mj":false,"qs":[{"q":"genetics","mj":true,"ui":"Q000235"}],"ui":"D008928"},{"d":"RNA Interference","mj":false,"qs":[{"q":"physiology","mj":false,"ui":"Q000502"}],"ui":"D034622"},{"d":"RNA, Small Untranslated","mj":false,"qs":[{"q":"genetics","mj":true,"ui":"Q000235"},{"q":"physiology","mj":false,"ui":"Q000502"}],"ui":"D058727"},{"d":"Sequence Analysis, RNA","mj":false,"qs":[{"q":"methods","mj":false,"ui":"Q000379"}],"ui":"D017423"},{"d":"Transcription, Genetic","mj":false,"qs":[{"q":"genetics","mj":false,"ui":"Q000235"}],"ui":"D014158"}],"chemicals":[{"n":"DNA, Mitochondrial","ui":"D004272","reg":"0"},{"n":"RNA, Small Untranslated","ui":"D058727","reg":"0"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://academic.oup.com/mbe/article-pdf/34/8/1960/24367304/msx140.pdf","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/bd0f80add71db1018d47d832d98e40b1b342ad6b","s2_open_access_license":"CCBYNC","s2_open_access_status":"HYBRID","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Abstract Typically, animal mitochondria have very compact genomes, with few short intergenic regions, and no introns. Hence, it may seem that there is little space for unknown functions in mitochondrial DNA (mtDNA). However, mtDNA can also operate through RNA interference, as small non coding RNAs (sncRNAs) produced by mtDNA have already been proposed for humans. We sequenced sncRNA libraries from isolated mitochondria of Ruditapes philippinarum (Mollusca Bivalvia) gonads, a species with doubly uniparental inheritance of mitochondria, and identified several putative sncRNAs of mitochondrial origin. Some sncRNAs are transcribed by intergenic regions that form stable stem-hairpin structures, which makes them good miRNA-like candidates. We decided to name them small mitochondrial highly-transcribed RNAs (smithRNAs). Many concurrent data support that we have recovered sncRNAs of mitochondrial origin that might be involved in gonad formation and able to affect nuclear gene expression. This possibility has been never suggested before. If mtDNA can affect nuclear gene expression through RNA interference, this opens a plethora of new possibilities for it to interact with the nucleus, and makes metazoan mtDNA a much more complex genome than previously thought.","claims":[{"public_id":"cl_dc5750ff04530a0569a969a94f04a8d7","status":"active","text":"Mitochondrial DNA can affect nuclear gene expression through RNA interference, making metazoan mitochondrial DNA a more complex genome than previously thought.","confidence":0.6,"contributors":[{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["extraction"],"url":"https://sah.borca.ai/u/322360f1c1"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ 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might be involved in gonad formation and able to affect nuclear gene expression.","confidence":0.7,"contributors":[{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["extraction"],"url":"https://sah.borca.ai/u/322360f1c1"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/claims/cl_6a215eee5d7db1ea92a78cdc8e12c524"},{"public_id":"cl_e164af97892359966253a1e88a7ac1df","status":"active","text":"sncRNA libraries sequenced from isolated mitochondria of Ruditapes philippinarum gonads yielded several putative small non coding RNAs of mitochondrial origin.","confidence":0.9,"contributors":[{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale 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