{"corpus_id":43703618,"paper_sha":"5ddbd16a351147562b70a8cf842f3f73d88878ef","doi":"10.1146/ANNUREV.ARPLANT.48.1.251","arxiv_id":null,"pmid":15012264,"pmcid":null,"mag_id":2164671653,"dblp_id":null,"acl_id":null,"title":"THE OXIDATIVE BURST IN PLANT DISEASE RESISTANCE.","year":1997,"publication_date":"1997-06-01","venue":"Annual Review of Plant Physiology and Plant Molecular Biology","journal":{"name":"Annual review of plant physiology and plant molecular biology","pages":"\n          251-275\n        ","volume":"48"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article"],"s2_fields_of_study":["Biology","Medicine","Environmental Science"],"reference_count":144,"citation_count":3296,"influential_citation_count":166,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":null,"chemicals":null,"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Rapid generation of superoxide and accumulation of H2O2 is a characteristic early feature of the hypersensitive response following perception of pathogen avirulence signals. Emerging data indicate that the oxidative burst reflects activation of a membrane-bound NADPH oxidase closely resembling that operating in activated neutrophils. The oxidants are not only direct protective agents, but H2O2 also functions as a substrate for oxidative cross-linking in the cell wall, as a threshold trigger for hypersensitive cell death, and as a diffusible signal for induction of cellular protectant genes in surrounding cells. 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