{"corpus_id":43772583,"paper_sha":"ba6e514cc103e69653d68c37dad5193068cc6983","doi":"10.1016/S0735-1097(02)02572-X","arxiv_id":null,"pmid":12475448,"pmcid":null,"mag_id":3021087797,"dblp_id":null,"acl_id":null,"title":"A long-term perspective on the protective effects of an early invasive strategy in unstable coronary artery disease: two-year follow-up of the FRISC-II invasive study.","year":2002,"publication_date":"2002-12-04","venue":"Journal of the American College of Cardiology","journal":{"name":"Journal of the American College of Cardiology","pages":"\n          1902-14\n        ","volume":"40 11"},"journal_issn":null,"journal_title":null,"publication_types":["Study","JournalArticle","ClinicalTrial"],"pubmed_pub_types":["Clinical Trial","Comparative Study","Journal Article","Multicenter Study","Randomized Controlled Trial","Research Support, Non-U.S. Gov't"],"s2_fields_of_study":["Medicine"],"reference_count":18,"citation_count":154,"influential_citation_count":3,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Aged","mj":false,"ui":"D000368"},{"d":"Angina, Unstable","mj":false,"qs":[{"q":"complications","mj":false,"ui":"Q000150"},{"q":"prevention & control","mj":false,"ui":"Q000517"}],"ui":"D000789"},{"d":"Coronary Artery Disease","mj":false,"qs":[{"q":"complications","mj":false,"ui":"Q000150"},{"q":"mortality","mj":true,"ui":"Q000401"},{"q":"prevention & control","mj":true,"ui":"Q000517"}],"ui":"D003324"},{"d":"Female","mj":false,"ui":"D005260"},{"d":"Follow-Up Studies","mj":false,"ui":"D005500"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Male","mj":false,"ui":"D008297"},{"d":"Middle Aged","mj":false,"ui":"D008875"},{"d":"Myocardial Infarction","mj":false,"qs":[{"q":"complications","mj":false,"ui":"Q000150"},{"q":"mortality","mj":false,"ui":"Q000401"},{"q":"prevention & control","mj":false,"ui":"Q000517"}],"ui":"D009203"},{"d":"Myocardial Revascularization","mj":false,"ui":"D009204"},{"d":"Patient Readmission","mj":false,"ui":"D010359"},{"d":"Prospective Studies","mj":false,"ui":"D011446"},{"d":"Recurrence","mj":false,"ui":"D012008"},{"d":"Scandinavian and Nordic Countries","mj":false,"qs":[{"q":"epidemiology","mj":false,"ui":"Q000453"}],"ui":"D012537"},{"d":"Survival Analysis","mj":false,"ui":"D016019"},{"d":"Time","mj":false,"ui":"D013995"},{"d":"Time Factors","mj":false,"ui":"D013997"},{"d":"Treatment Outcome","mj":false,"ui":"D016896"}],"chemicals":null,"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"OBJECTIVES\nWe sought to report the first and repeat events and to separate spontaneous and procedure-related events over two years in the Fast Revascularization during InStability in Coronary artery disease (FRISC-II) invasive trial.\n\n\nBACKGROUND\nThe FRISC-II invasive trial compared the long-term effects of an early invasive versus noninvasive strategy, in terms of death and myocardial infarction (MI) and the need for repeat hospital admissions and late revascularization procedures in patients with coronary artery disease (UCAD).\n\n\nMETHODS\nIn the FRISC-II trial, 2,457 patients with UCAD were randomized to an early invasive or noninvasive strategy.\n\n\nRESULTS\nAt 24 month follow-up, there were reductions in mortality (n = 45 [3.7%] vs. 67 [5.4%]; risk ratio 0.68 [95% confidence interval (CI) 0.47 to 0.98]; p = 0.038), MI (n = 111 [9.2%] vs. 156 [12.7%]; risk ratio 0.72 [95% CI 0.57 to 0.91]; p = 0.005), and the composite end point of death or MI (n = 146 [12.1%] vs. 200 [16.3%]; risk ratio 0.74 [95% CI 0.61 to 0.90]; p = 0.003) in the invasive compared with the noninvasive group. Procedure-related MIs were two to three times more common, but spontaneous ones were three times less common in the invasive than in the noninvasive group. After the first year, there was no difference in mortality (n = 20 [1.7%]) between the two groups and fewer MIs in the invasive group (p = 0.031).\n\n\nCONCLUSIONS\nIn UCAD, the early invasive approach leads to a sustained reduction in mortality, cardiac morbidity, and the need for repeat hospital admissions and late revascularization procedures. Although the benefits are greatest during the first months, during the second year, cardiac morbidity is lower and the need for hospital care is less in the invasive group.","claims":[{"public_id":"cl_8d8815d624590f806bc65b7c1dc1c5d6","status":"active","text":"After the first year, mortality was similar between groups, but myocardial infarctions remained fewer in the invasive group.","confidence":0.9,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_8d8815d624590f806bc65b7c1dc1c5d6"},{"public_id":"cl_bd883b63c071c0cf4d02f0de21d46fcf","status":"active","text":"Early invasive strategy reduced 24-month mortality, myocardial infarction, and the composite end point of death or myocardial infarction compared with the noninvasive strategy in unstable coronary artery 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