{"corpus_id":45043550,"paper_sha":"8f6f5a31f96196bba83bcf36ce1836c35aeda7e5","doi":"10.1113/jphysiol.1952.sp004731","arxiv_id":null,"pmid":14946728,"pmcid":"PMC1392566","mag_id":1583607933,"dblp_id":null,"acl_id":null,"title":"The effect of inhalation of high and low concentrations of oxygen on the respiration of the premature infant","year":1952,"publication_date":"1952-05-28","venue":"Journal of Physiology","journal":{"name":"The Journal of Physiology","pages":null,"volume":"117"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article"],"s2_fields_of_study":["Medicine","Chemistry"],"reference_count":4,"citation_count":183,"influential_citation_count":3,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Administration, Inhalation","mj":true,"ui":"D000280"},{"d":"Cell Respiration","mj":true,"ui":"D019069"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Infant, Newborn","mj":false,"ui":"D007231"},{"d":"Infant, Premature","mj":true,"ui":"D007234"},{"d":"Oxygen","mj":false,"qs":[{"q":"pharmacology","mj":true,"ui":"Q000494"}],"ui":"D010100"},{"d":"Respiration","mj":false,"qs":[{"q":"drug effects","mj":true,"ui":"Q000187"}],"ui":"D012119"}],"chemicals":[{"n":"Oxygen","ui":"D010100","reg":"S88TT14065"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"In a previous investigation (Cross & Warner, 1951) the respiratory adjustments of the normal full-term infant were studied when 100 % oxygen and a mixture of 15 % oxygen and 85 % nitrogen were administered. There appeared to be marked quantitative differences between these results in the newborn and those reported by Dripps & Comroe (1947) in the adult human subject. But whether this was due to a true biological difference, or to a difference between the methods of recording, could not be judged. In this investigation we have studied the reactions of premature infants to the same gas mixtures, using the same apparatus as was used previously, and we have been able to examine whether the trends previously observed were continued in the least mature subjects. The results reported here are mainly concerned with minute volume because, if this figure may be interpreted in terms of Effective Alveolar Ventilation, it represents the single most important factor in external respiration. Tidal air has been reported as an average figure, derived from a measurement of the minute volume and respiration rate for each minute, but these three figures alone afford an incomplete picture of the respiratory behaviour of the baby. There may be not only phasic changes in rate and rhythm, but also frank respiratory irregularity in the sleeping baby, as is illustrated in Cross & Oppe (1952). Without making a complete analysis of these irregularities of rhythm, we have attempted to indicate in a simple quantitative fashion the major modifications of periodic breathing related to the test gases.","claims":[{"public_id":"cl_b25edb674475fc74dbc4c04c059343cf","status":"active","text":"Major modifications of periodic breathing related to the test gases were quantified in a simple way without a complete analysis of respiratory irregularities.","confidence":0.88,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_b25edb674475fc74dbc4c04c059343cf"},{"public_id":"cl_80f1ae12f9df05f05c54ac5b10dd89c3","status":"active","text":"Premature infants were studied with the same apparatus previously used for full-term infants while breathing 100% oxygen and a mixture of 15% oxygen and 85% nitrogen.","confidence":0.97,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_80f1ae12f9df05f05c54ac5b10dd89c3"},{"public_id":"cl_9e5ed8d329021440c864a97624408932","status":"active","text":"The investigation focused mainly on minute volume as the key measure of external respiration in these infants.","confidence":0.95,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_9e5ed8d329021440c864a97624408932"},{"public_id":"cl_c463df02e1d27e7b6ccfec8aa807a5f4","status":"active","text":"The measurements were used to assess whether the respiratory trends previously observed in full-term newborns extended to the least mature 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