{"corpus_id":45156267,"paper_sha":"a52dcd89e856fe660c4cf294f98b05900e7a90e8","doi":"10.1016/0014-5793(76)80811-3","arxiv_id":null,"pmid":1001470,"pmcid":null,"mag_id":1967794225,"dblp_id":null,"acl_id":null,"title":"In vitro studies into the effect of inhibition of rat brain succinic semialdehyde dehydrogenase on GABA synthesis and degradation","year":1976,"publication_date":"1976-12-15","venue":"FEBS Letters","journal":{"name":"FEBS Letters","pages":null,"volume":"72"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article"],"s2_fields_of_study":["Biology","Medicine","Chemistry"],"reference_count":14,"citation_count":45,"influential_citation_count":0,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Aldehyde Oxidoreductases","mj":false,"qs":[{"q":"metabolism","mj":true,"ui":"Q000378"}],"ui":"D000445"},{"d":"Aldehydes","mj":false,"qs":[{"q":"pharmacology","mj":false,"ui":"Q000494"}],"ui":"D000447"},{"d":"Aminobutyrates","mj":false,"qs":[{"q":"metabolism","mj":true,"ui":"Q000378"}],"ui":"D000613"},{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Brain","mj":false,"qs":[{"q":"metabolism","mj":true,"ui":"Q000378"}],"ui":"D001921"},{"d":"Fatty Acids, Nonesterified","mj":false,"qs":[{"q":"pharmacology","mj":false,"ui":"Q000494"}],"ui":"D005230"},{"d":"Rats","mj":false,"ui":"D051381"},{"d":"Succinates","mj":false,"qs":[{"q":"pharmacology","mj":false,"ui":"Q000494"}],"ui":"D013386"},{"d":"gamma-Aminobutyric Acid","mj":false,"qs":[{"q":"metabolism","mj":true,"ui":"Q000378"}],"ui":"D005680"}],"chemicals":[{"n":"Aldehydes","ui":"D000447","reg":"0"},{"n":"Aminobutyrates","ui":"D000613","reg":"0"},{"n":"Fatty Acids, Nonesterified","ui":"D005230","reg":"0"},{"n":"Succinates","ui":"D013386","reg":"0"},{"n":"gamma-Aminobutyric Acid","ui":"D005680","reg":"56-12-2"},{"n":"Aldehyde Oxidoreductases","ui":"D000445","reg":"EC 1.2.-"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2876%2980811-3","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/a52dcd89e856fe660c4cf294f98b05900e7a90e8","s2_open_access_license":null,"s2_open_access_status":"BRONZE","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"The inhibitory role of GABA in certain central nervous system mechanisms is well known [ 1 ] . As GABA itself does not normally traverse the bloodbrain barrier various inhibitors of GABA transaminase have been used in order to increase its cerebral level [2]. However, most of these inhibitors which cross the blood-brain barrier act on the coenzyme, pyridoxal phosphate, and hence are very toxic and. not specific for GABA-T. Some branched chain fatty acids inhibit purified GABA-T [3-51 as well as succinic semialdehyde dehydrogenase [6-71. 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