{"corpus_id":45204272,"paper_sha":"566c7c6ef6e5ac5bdcfb01b9740e764cd8c1216a","doi":"10.1074/JBC.M005458200","arxiv_id":null,"pmid":11053409,"pmcid":null,"mag_id":1985016681,"dblp_id":null,"acl_id":null,"title":"JAM-2, a Novel Immunoglobulin Superfamily Molecule, Expressed by Endothelial and Lymphatic Cells*","year":2001,"publication_date":"2001-01-26","venue":"Journal of Biological Chemistry","journal":{"name":"The Journal of Biological Chemistry","pages":"2733 - 2741","volume":"276"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, Non-U.S. Gov't"],"s2_fields_of_study":["Biology","Medicine"],"reference_count":51,"citation_count":260,"influential_citation_count":20,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Amino Acid Sequence","mj":false,"ui":"D000595"},{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Base Sequence","mj":false,"ui":"D001483"},{"d":"Cell Adhesion Molecules","mj":false,"qs":[{"q":"genetics","mj":false,"ui":"Q000235"},{"q":"isolation & purification","mj":true,"ui":"Q000302"}],"ui":"D015815"},{"d":"Cell Compartmentation","mj":false,"ui":"D002451"},{"d":"Cell Polarity","mj":false,"ui":"D016764"},{"d":"Endothelium, Lymphatic","mj":false,"qs":[{"q":"chemistry","mj":true,"ui":"Q000737"},{"q":"ultrastructure","mj":false,"ui":"Q000648"}],"ui":"D004729"},{"d":"Endothelium, Vascular","mj":false,"qs":[{"q":"chemistry","mj":true,"ui":"Q000737"},{"q":"ultrastructure","mj":false,"ui":"Q000648"}],"ui":"D004730"},{"d":"Immunoglobulins","mj":false,"qs":[{"q":"genetics","mj":false,"ui":"Q000235"},{"q":"isolation & purification","mj":true,"ui":"Q000302"}],"ui":"D007136"},{"d":"Kidney","mj":false,"qs":[{"q":"blood supply","mj":false,"ui":"Q000098"}],"ui":"D007668"},{"d":"Membrane Proteins","mj":false,"qs":[{"q":"genetics","mj":false,"ui":"Q000235"},{"q":"isolation & purification","mj":true,"ui":"Q000302"}],"ui":"D008565"},{"d":"Mice","mj":false,"ui":"D051379"},{"d":"Molecular Sequence Data","mj":false,"ui":"D008969"},{"d":"Receptors, Cell Surface","mj":true,"ui":"D011956"},{"d":"Sequence Homology, Amino Acid","mj":false,"ui":"D017386"},{"d":"Tight Junctions","mj":false,"qs":[{"q":"chemistry","mj":true,"ui":"Q000737"},{"q":"ultrastructure","mj":false,"ui":"Q000648"}],"ui":"D019108"},{"d":"Tissue Distribution","mj":false,"ui":"D014018"},{"d":"Junctional Adhesion Molecule B","mj":false,"ui":"D062765"}],"chemicals":[{"n":"Cell Adhesion Molecules","ui":"D015815","reg":"0"},{"n":"Immunoglobulins","ui":"D007136","reg":"0"},{"n":"Membrane Proteins","ui":"D008565","reg":"0"},{"n":"Receptors, Cell Surface","ui":"D011956","reg":"0"},{"n":"F11r protein, mouse","ui":"C498686","reg":"0"},{"n":"Jam2 protein, mouse","ui":"C498781","reg":"0"},{"n":"Junctional Adhesion Molecule B","ui":"D062765","reg":"0"},{"n":"Jam3 protein, mouse","ui":"C486723","reg":"0"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"http://www.jbc.org/article/S0021925818466239/pdf","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/566c7c6ef6e5ac5bdcfb01b9740e764cd8c1216a","s2_open_access_license":"CCBY","s2_open_access_status":"HYBRID","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Cell-cell contacts are essential for morphogenesis and tissue function and play a vital role in mediating endothelial cohesion within the vascular system during vessel growth and organization. We identified a novel junctional adhesion molecule, named JAM-2, by a selective RNA display method, which allowed identification of transcripts encoding immunoglobulin superfamily molecules regulated during coculture of endothelial cells with tumor cells. The JAM-2 transcript is highly expressed during embryogenesis and is detected in lymph node and Peyer's patches RNA of adult mice. Accordingly, antibodies specific for JAM-2 stain high endothelial venules and lymphatic vessels in lymphoid organs, and vascular structures in the kidney. Using real time video microscopy, we show that JAM-2 is localized within minutes to the newly formed cell-cell contact. The role of the protein in the sealing of cell-cell contact is further suggested by the reduced paracellular permeability of cell monolayer transfected with JAM-2 cDNA, and by the localization of JAM-2 to tight junctional complexes of polarized cells. Taken together, our results suggest that JAM-2 is a novel vascular molecule, which participates in interendothelial junctional complexes.","claims":[{"public_id":"cl_c61b5b975d8d7ca88949cc63ce8e0b5f","status":"active","text":"Antibodies specific for JAM-2 stain high endothelial venules and lymphatic vessels in lymphoid organs, and vascular structures in the kidney.","confidence":0.9,"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":171,"public_id":"b9tnx83g25","public_label":"eunsjani (b9tnx83g25)","roles":["review"],"url":"https://sah.borca.ai/u/b9tnx83g25"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/claims/cl_c61b5b975d8d7ca88949cc63ce8e0b5f"},{"public_id":"cl_eefe2894cd12cddb8b707ea69e1cb316","status":"active","text":"JAM-2 is a novel immunoglobulin superfamily molecule expressed by endothelial and lymphatic cells, identified by a selective RNA display method that detected transcripts regulated during coculture of endothelial cells with tumor cells.","confidence":0.95,"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":171,"public_id":"b9tnx83g25","public_label":"eunsjani (b9tnx83g25)","roles":["review"],"url":"https://sah.borca.ai/u/b9tnx83g25"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/claims/cl_eefe2894cd12cddb8b707ea69e1cb316"},{"public_id":"cl_f953786d27c246ad838b5fcda78d12db","status":"active","text":"JAM-2 localizes within minutes to newly formed cell-cell contacts, as shown by real-time video microscopy.","confidence":0.85,"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":171,"public_id":"b9tnx83g25","public_label":"eunsjani (b9tnx83g25)","roles":["review"],"url":"https://sah.borca.ai/u/b9tnx83g25"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/claims/cl_f953786d27c246ad838b5fcda78d12db"},{"public_id":"cl_00c83497c0a2583010f1588df1b9347c","status":"active","text":"JAM-2 transcript is highly expressed during embryogenesis and detected in lymph node and Peyer's patches RNA of adult mice.","confidence":0.9,"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":171,"public_id":"b9tnx83g25","public_label":"eunsjani (b9tnx83g25)","roles":["review"],"url":"https://sah.borca.ai/u/b9tnx83g25"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/claims/cl_00c83497c0a2583010f1588df1b9347c"},{"public_id":"cl_86fd1ea952a96286c2004434ecb87399","status":"active","text":"Transfection of JAM-2 cDNA reduces paracellular permeability of cell monolayers, and JAM-2 localizes to tight junctional complexes of polarized cells, suggesting a role in sealing cell-cell contacts.","confidence":0.85,"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":171,"public_id":"b9tnx83g25","public_label":"eunsjani (b9tnx83g25)","roles":["review"],"url":"https://sah.borca.ai/u/b9tnx83g25"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/claims/cl_86fd1ea952a96286c2004434ecb87399"}],"concepts":[{"public_id":"co_1931d892347b40f79002798e18b0c565","status":"active","name":"JAM-2 cDNA","description":"Complementary DNA encoding JAM-2, used for transfection into cell monolayers to study paracellular permeability.","types":["reagent"],"aliases":[],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":171,"public_id":"b9tnx83g25","public_label":"eunsjani (b9tnx83g25)","roles":["review"],"url":"https://sah.borca.ai/u/b9tnx83g25"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/concepts/co_1931d892347b40f79002798e18b0c565"},{"public_id":"co_29807bbf36743c7337ac77a394c07e01","status":"active","name":"real-time video microscopy","description":"Microscopy technique used to visualize JAM-2 localization to newly formed cell-cell contacts over time.","types":["method"],"aliases":[],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":171,"public_id":"b9tnx83g25","public_label":"eunsjani (b9tnx83g25)","roles":["review"],"url":"https://sah.borca.ai/u/b9tnx83g25"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/concepts/co_29807bbf36743c7337ac77a394c07e01"},{"public_id":"co_29916a56fc9acdfebe27b4ecfae396c2","status":"active","name":"lymph node","description":"A lymphoid organ where JAM-2 transcript is detected in adult mice and where JAM-2-specific antibodies stain high endothelial venules.","types":["anatomical structure"],"aliases":[],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":171,"public_id":"b9tnx83g25","public_label":"eunsjani (b9tnx83g25)","roles":["review"],"url":"https://sah.borca.ai/u/b9tnx83g25"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/concepts/co_29916a56fc9acdfebe27b4ecfae396c2"},{"public_id":"co_2efc82eff695d230f0fbc31b3f83cf3c","status":"active","name":"embryogenesis","description":"The developmental process during which JAM-2 transcript is highly expressed.","types":["biological process"],"aliases":[],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":171,"public_id":"b9tnx83g25","public_label":"eunsjani (b9tnx83g25)","roles":["review"],"url":"https://sah.borca.ai/u/b9tnx83g25"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/concepts/co_2efc82eff695d230f0fbc31b3f83cf3c"},{"public_id":"co_37515d07b3546830c6611795b6d1daaa","status":"active","name":"lymphatic vessels","description":"Vessels of the lymphatic system stained by JAM-2-specific antibodies in lymphoid organs.","types":["anatomical structure"],"aliases":[],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":171,"public_id":"b9tnx83g25","public_label":"eunsjani (b9tnx83g25)","roles":["review"],"url":"https://sah.borca.ai/u/b9tnx83g25"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/concepts/co_37515d07b3546830c6611795b6d1daaa"},{"public_id":"co_388415ef7364e48ec26e6d6d083698e9","status":"active","name":"JAM-2 transcript","description":"The RNA transcript encoding JAM-2, highly expressed during embryogenesis and detected in adult mouse lymph node and Peyer's patches.","types":["transcript"],"aliases":[],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":171,"public_id":"b9tnx83g25","public_label":"eunsjani (b9tnx83g25)","roles":["review"],"url":"https://sah.borca.ai/u/b9tnx83g25"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/concepts/co_388415ef7364e48ec26e6d6d083698e9"},{"public_id":"co_4fad727c2f95d2546088a2abf14d089e","status":"active","name":"paracellular permeability","description":"The permeability of cell monolayers through intercellular spaces, reduced upon transfection with JAM-2 cDNA.","types":["measurement"],"aliases":[],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":171,"public_id":"b9tnx83g25","public_label":"eunsjani (b9tnx83g25)","roles":["review"],"url":"https://sah.borca.ai/u/b9tnx83g25"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/concepts/co_4fad727c2f95d2546088a2abf14d089e"},{"public_id":"co_58d2592c7911628759714ab29bc009f1","status":"active","name":"Peyer's patches","description":"Lymphoid nodules in the small intestine where JAM-2 transcript is detected in adult mice.","types":["anatomical structure"],"aliases":[],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":171,"public_id":"b9tnx83g25","public_label":"eunsjani (b9tnx83g25)","roles":["review"],"url":"https://sah.borca.ai/u/b9tnx83g25"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/concepts/co_58d2592c7911628759714ab29bc009f1"},{"public_id":"co_62f293108886171209352c1632dcbb8f","status":"active","name":"vascular structures in kidney","description":"Blood vessel structures in the kidney stained by JAM-2-specific antibodies.","types":["anatomical structure"],"aliases":[],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":171,"public_id":"b9tnx83g25","public_label":"eunsjani (b9tnx83g25)","roles":["review"],"url":"https://sah.borca.ai/u/b9tnx83g25"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/concepts/co_62f293108886171209352c1632dcbb8f"},{"public_id":"co_8859b4fb0371a0bd4776aa5cff85a4e1","status":"active","name":"immunoglobulin superfamily","description":"A family of cell-surface proteins characterized by immunoglobulin-like domains, to which JAM-2 belongs.","types":["protein family"],"aliases":["IgSF"],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":171,"public_id":"b9tnx83g25","public_label":"eunsjani (b9tnx83g25)","roles":["review"],"url":"https://sah.borca.ai/u/b9tnx83g25"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/concepts/co_8859b4fb0371a0bd4776aa5cff85a4e1"},{"public_id":"co_8afe690daa810871a1d863b892bfa38d","status":"active","name":"selective RNA display method","description":"A technique used to identify transcripts encoding immunoglobulin superfamily molecules regulated during coculture of endothelial cells with tumor cells.","types":["method"],"aliases":[],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":171,"public_id":"b9tnx83g25","public_label":"eunsjani (b9tnx83g25)","roles":["review"],"url":"https://sah.borca.ai/u/b9tnx83g25"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/concepts/co_8afe690daa810871a1d863b892bfa38d"},{"public_id":"co_b3ded0fc20775a8715509b20fbd088e9","status":"active","name":"high endothelial venules","description":"Specialized blood vessels in lymphoid organs stained by JAM-2-specific antibodies.","types":["anatomical structure"],"aliases":["HEVs"],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":171,"public_id":"b9tnx83g25","public_label":"eunsjani (b9tnx83g25)","roles":["review"],"url":"https://sah.borca.ai/u/b9tnx83g25"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/concepts/co_b3ded0fc20775a8715509b20fbd088e9"},{"public_id":"co_b50ba1ddf594e2a2f79f60170356cb8e","status":"active","name":"cell-cell contacts","description":"Newly formed junctions between cells where JAM-2 localizes within minutes, observed by real-time video microscopy.","types":["cellular structure"],"aliases":[],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":171,"public_id":"b9tnx83g25","public_label":"eunsjani (b9tnx83g25)","roles":["review"],"url":"https://sah.borca.ai/u/b9tnx83g25"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/concepts/co_b50ba1ddf594e2a2f79f60170356cb8e"},{"public_id":"co_bfac59c60385022f8888866e3c33d658","status":"active","name":"tight junctional complexes","description":"Intercellular junction structures where JAM-2 localizes in polarized cells, contributing to sealing of cell-cell contacts.","types":["cellular structure"],"aliases":[],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":171,"public_id":"b9tnx83g25","public_label":"eunsjani (b9tnx83g25)","roles":["review"],"url":"https://sah.borca.ai/u/b9tnx83g25"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/concepts/co_bfac59c60385022f8888866e3c33d658"},{"public_id":"co_dd285de140002eea4b32d5d09ef82046","status":"active","name":"JAM-2","description":"A novel junctional adhesion molecule belonging to the immunoglobulin superfamily, expressed by endothelial and lymphatic cells.","types":["protein","molecule"],"aliases":["junctional adhesion molecule 2"],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":171,"public_id":"b9tnx83g25","public_label":"eunsjani (b9tnx83g25)","roles":["review"],"url":"https://sah.borca.ai/u/b9tnx83g25"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/concepts/co_dd285de140002eea4b32d5d09ef82046"},{"public_id":"co_fb3fe7a5f9bc21759d4e046b543dc06e","status":"active","name":"JAM-2-specific antibodies","description":"Antibodies that bind specifically to JAM-2, used to stain high endothelial venules, lymphatic vessels, and kidney vascular structures.","types":["reagent"],"aliases":[],"contributors":[{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["extraction"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":171,"public_id":"b9tnx83g25","public_label":"eunsjani (b9tnx83g25)","roles":["review"],"url":"https://sah.borca.ai/u/b9tnx83g25"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/concepts/co_fb3fe7a5f9bc21759d4e046b543dc06e"}],"external_ids":{"DOI":"10.1074/JBC.M005458200","ArXiv":null,"PubMed":11053409,"PubMedCentral":null,"MAG":1985016681,"DBLP":null,"ACL":null},"open_access":{"is_open_access":true,"pdf_url":"http://www.jbc.org/article/S0021925818466239/pdf","landing_url":"https://www.semanticscholar.org/paper/566c7c6ef6e5ac5bdcfb01b9740e764cd8c1216a","source":"semantic_scholar","pdf_url_source":"semantic_scholar_open_access_pdf","license":"CCBY","status":"HYBRID","reason":null},"reference_availability":{"status":"available","references_indexed":true,"full_text_available":false,"full_text_source":null,"count_basis":"semantic_scholar_metadata","extraction_status":"not_applicable","reason":null},"source":{"provider":"episteme2","base_corpus":"semantic_scholar_dump","freshness_mode":"unknown","basis":["semantic_scholar_metadata","postgres_metadata"],"limits":["paper metadata is based on indexed upstream scholarly datasets","claims and concepts are available only for extracted papers","absence of claims or concepts means no extracted graph data is available in this response"],"status":"available","degraded":false,"degraded_reasons":[],"diagnostics":{"status":"available","degraded":false,"degraded_reasons":[],"metadata_status":"available","graph_status":"available","abstract_status":"available"},"source_flags":5},"paper_id":638579,"paper_uid":"6ed35e63-f023-4145-bbc0-3b8c8d2baee3","canonical_identity":{"paper_id":638579,"paper_uid":"6ed35e63-f023-4145-bbc0-3b8c8d2baee3","identity_status":"available","lookup_basis":"semantic_scholar_external_id","compatibility_path":"corpus_id"},"url":"https://sah.borca.ai/papers/45204272"}