{"corpus_id":45301612,"paper_sha":"660084324e8ef7c5edd6421f7d1318df008bad1a","doi":"10.1006/BBRC.1995.2296","arxiv_id":null,"pmid":7677742,"pmcid":null,"mag_id":2073743870,"dblp_id":null,"acl_id":null,"title":"Induction of tumor suppressor p21 protein by kinase inhibitors in MCF-7 cells.","year":1995,"publication_date":"1995-09-14","venue":"Biochemical and Biophysical Research Communications - BBRC","journal":{"name":"Biochemical and biophysical research communications","pages":"\n          361-6\n        ","volume":"214 2"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, U.S. Gov't, P.H.S."],"s2_fields_of_study":["Biology","Medicine","Chemistry"],"reference_count":0,"citation_count":22,"influential_citation_count":0,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","mj":false,"ui":"D019307"},{"d":"Alkaloids","mj":false,"qs":[{"q":"pharmacology","mj":true,"ui":"Q000494"}],"ui":"D000470"},{"d":"Breast Neoplasms","mj":false,"ui":"D001943"},{"d":"Bucladesine","mj":false,"qs":[{"q":"pharmacology","mj":false,"ui":"Q000494"}],"ui":"D003994"},{"d":"Cell Cycle","mj":false,"qs":[{"q":"drug effects","mj":false,"ui":"Q000187"}],"ui":"D002453"},{"d":"Cell Division","mj":false,"qs":[{"q":"drug effects","mj":false,"ui":"Q000187"}],"ui":"D002455"},{"d":"Cell Line","mj":false,"ui":"D002460"},{"d":"Cyclin-Dependent Kinase Inhibitor p21","mj":false,"ui":"D050759"},{"d":"Cyclins","mj":false,"qs":[{"q":"biosynthesis","mj":true,"ui":"Q000096"},{"q":"isolation & purification","mj":false,"ui":"Q000302"}],"ui":"D016213"},{"d":"Enzyme Inhibitors","mj":true,"ui":"D004791"},{"d":"Flow Cytometry","mj":false,"ui":"D005434"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Isoquinolines","mj":false,"qs":[{"q":"pharmacology","mj":true,"ui":"Q000494"}],"ui":"D007546"},{"d":"Kinetics","mj":false,"ui":"D007700"},{"d":"Piperazines","mj":false,"qs":[{"q":"pharmacology","mj":true,"ui":"Q000494"}],"ui":"D010879"},{"d":"Protein Kinase C","mj":false,"qs":[{"q":"antagonists & inhibitors","mj":true,"ui":"Q000037"}],"ui":"D011493"},{"d":"Protein Serine-Threonine Kinases","mj":false,"qs":[{"q":"antagonists & inhibitors","mj":true,"ui":"Q000037"}],"ui":"D017346"},{"d":"Staurosporine","mj":false,"ui":"D019311"},{"d":"Tumor Cells, Cultured","mj":false,"ui":"D014407"}],"chemicals":[{"n":"Alkaloids","ui":"D000470","reg":"0"},{"n":"CDKN1A protein, human","ui":"C493956","reg":"0"},{"n":"Cyclin-Dependent Kinase Inhibitor p21","ui":"D050759","reg":"0"},{"n":"Cyclins","ui":"D016213","reg":"0"},{"n":"Enzyme Inhibitors","ui":"D004791","reg":"0"},{"n":"Isoquinolines","ui":"D007546","reg":"0"},{"n":"Piperazines","ui":"D010879","reg":"0"},{"n":"Bucladesine","ui":"D003994","reg":"63X7MBT2LQ"},{"n":"1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine","ui":"D019307","reg":"84477-87-2"},{"n":"Protein Serine-Threonine Kinases","ui":"D017346","reg":"EC 2.7.11.1"},{"n":"Protein Kinase C","ui":"D011493","reg":"EC 2.7.11.13"},{"n":"Staurosporine","ui":"D019311","reg":"H88EPA0A3N"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"The expression level of tumor suppressor p21 protein in response to protein kinase inhibitors was examined in MCF-7 cells. 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