{"corpus_id":45619982,"paper_sha":"976399369665f46824a98d6772191b5df8d92907","doi":"10.1016/s0022-3565(25)05801-x","arxiv_id":null,"pmid":20285832,"pmcid":null,"mag_id":2259579922,"dblp_id":null,"acl_id":null,"title":"The chronic toxicity and pathology of thiouracil in cats.","year":1947,"publication_date":"1947-02-01","venue":"Journal of Pharmacology and Experimental Therapeutics","journal":{"name":"The Journal of pharmacology and experimental therapeutics","pages":"\n          125-30\n        ","volume":"89 2"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article"],"s2_fields_of_study":["Medicine"],"reference_count":0,"citation_count":4,"influential_citation_count":0,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Cats","mj":false,"ui":"D002415"},{"d":"Thiouracil","mj":false,"qs":[{"q":"toxicity","mj":true,"ui":"Q000633"}],"ui":"D013889"}],"chemicals":[{"n":"Thiouracil","ui":"D013889","reg":"59X161SCYL"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Thiouracil fed to cats in doses of up to 300 mg. per kg. per day for a period of 7 to 8 months had no demonstrable toxic effects, it had no appreciable effect on the hematocrit, it had an inconstant effect on the hemoglobin, no effect on plasma bilirubin, and only slight effect in delaying the rate of elimination of intravenously injected bilirubin in about half of the animals. Daily doses of 500 mg. per kg. in three cats proved fatal in 38 to 90 days. The significant pathologic findings appear to be necrosis and scarring in the reticular zone of the adrenal cortex, moderate fatty degeneration in the liver, with glycogen preservation, atrophy of the thyroid and of the seminiferous tubules of the testis, hyperplasia of testicular interstitial cells and a moderate hepatic and splenic hemosiderosis.","claims":[{"public_id":"cl_303866920d4be49ea4f6e2f7dc42ffe5","status":"active","text":"Daily thiouracil doses of 500 mg/kg were fatal in three cats within 38 to 90 days.","confidence":0.99,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_303866920d4be49ea4f6e2f7dc42ffe5"},{"public_id":"cl_03a3b467eeb579ae1015cb2ca62a1071","status":"active","text":"The main pathologic findings were necrosis and scarring in the reticular zone of the adrenal cortex, moderate fatty degeneration in the liver with glycogen preservation, atrophy of the thyroid and seminiferous tubules, hyperplasia of testicular interstitial cells, and moderate hepatic and splenic hemosiderosis.","confidence":0.98,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_03a3b467eeb579ae1015cb2ca62a1071"},{"public_id":"cl_26b2d2513a4558090aa454f7d1a77059","status":"active","text":"Thiouracil at doses up to 300 mg/kg/day for 7 to 8 months produced no demonstrable toxic effects in cats.","confidence":0.99,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_26b2d2513a4558090aa454f7d1a77059"},{"public_id":"cl_b3d7bde06d4af14c5c8ac8bb9b18bfbb","status":"active","text":"Thiouracil had no appreciable effect on the hematocrit, no effect on plasma bilirubin, and only a slight delay in intravenous bilirubin elimination in about half of the cats.","confidence":0.98,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_b3d7bde06d4af14c5c8ac8bb9b18bfbb"}],"concepts":[{"public_id":"co_2169a534a1fbf88b9b8610aa01fb3b0c","status":"active","name":"intravenous bilirubin elimination","description":"The rate at which injected bilirubin is cleared from the bloodstream.","types":["physiological process","measurement"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_2169a534a1fbf88b9b8610aa01fb3b0c"},{"public_id":"co_2aa78bb906a5aa9e8599c5c21fd501ff","status":"active","name":"thiouracil","description":"A thiourea-derived antithyroid compound administered here in varying daily doses to cats.","types":["compound","drug"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_2aa78bb906a5aa9e8599c5c21fd501ff"},{"public_id":"co_3b29cf6aef44b28c46d3df6860090ae0","status":"active","name":"plasma bilirubin","description":"The concentration of bilirubin in blood plasma, used as a liver-related biochemical measure.","types":["laboratory measurement"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_3b29cf6aef44b28c46d3df6860090ae0"},{"public_id":"co_4c47fd62577410c3c8a97a9a3d9f0fea","status":"active","name":"liver","description":"The organ assessed for fatty degeneration, glycogen preservation, and hemosiderosis.","types":["anatomical structure"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_4c47fd62577410c3c8a97a9a3d9f0fea"},{"public_id":"co_4e9cb8c44c6ad217630a9d5500bde45e","status":"active","name":"hematocrit","description":"The proportion of blood volume occupied by red blood cells.","types":["laboratory measurement"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_4e9cb8c44c6ad217630a9d5500bde45e"},{"public_id":"co_5bf3d0c1d75ff6362f09c59c0f0055da","status":"active","name":"fatality","description":"Death of the treated animals following exposure.","types":["outcome"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_5bf3d0c1d75ff6362f09c59c0f0055da"},{"public_id":"co_64c2b7523cdc7db0f847ab74f2859d02","status":"active","name":"thyroid","description":"The endocrine gland examined for atrophy.","types":["anatomical structure"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_64c2b7523cdc7db0f847ab74f2859d02"},{"public_id":"co_96b31af93bdbb12e6ecde8a0c591e613","status":"active","name":"hemochromatosis-like hemosiderosis","description":"Pathological iron deposition in the liver and spleen.","types":["pathology"],"aliases":["hepatic and splenic hemosiderosis","hemosiderosis"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_96b31af93bdbb12e6ecde8a0c591e613"},{"public_id":"co_9e567986c18279b377dc1ff923a13067","status":"active","name":"adrenal cortex","description":"The outer region of the adrenal gland, examined for pathological change.","types":["anatomical structure"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_9e567986c18279b377dc1ff923a13067"},{"public_id":"co_a7148e209f762e2f456ece855a034218","status":"active","name":"toxic effects","description":"Adverse biological effects caused by exposure to a substance.","types":["outcome","toxicity endpoint"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_a7148e209f762e2f456ece855a034218"},{"public_id":"co_e059e6699e5acf91577b30ddc6cb86cd","status":"active","name":"cats","description":"The animal model used to assess thiouracil toxicity and pathology.","types":["animal model"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_e059e6699e5acf91577b30ddc6cb86cd"},{"public_id":"co_e0d81ce80d6f08a3d51e3242f0f8dbac","status":"active","name":"seminiferous tubules","description":"Testicular tubules involved in sperm production, assessed here for atrophy.","types":["anatomical structure"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_e0d81ce80d6f08a3d51e3242f0f8dbac"}],"external_ids":{"DOI":"10.1016/s0022-3565(25)05801-x","ArXiv":null,"PubMed":20285832,"PubMedCentral":null,"MAG":2259579922,"DBLP":null,"ACL":null},"open_access":{"is_open_access":false,"pdf_url":null,"landing_url":"https://sah.borca.ai/papers/45619982","source":null,"pdf_url_source":null,"license":null,"reason":"pdf_url_not_indexed"},"reference_availability":{"status":"unknown","references_indexed":false,"full_text_available":false,"full_text_source":null,"count_basis":"semantic_scholar_metadata","extraction_status":"not_applicable","reason":null},"source":{"provider":"episteme2","base_corpus":"semantic_scholar_dump","freshness_mode":"unknown","basis":["semantic_scholar_metadata","postgres_metadata"],"limits":["paper metadata is based on indexed upstream scholarly datasets","claims and concepts are available only for extracted papers","absence of claims or concepts means no extracted graph data is available in this response"],"status":"available","degraded":false,"degraded_reasons":[],"diagnostics":{"status":"available","degraded":false,"degraded_reasons":[],"metadata_status":"available","graph_status":"available","abstract_status":"available"},"source_flags":5},"paper_id":630542,"paper_uid":"7b0e44fe-7cbf-41e5-9047-a246b9c5b9ac","canonical_identity":{"paper_id":630542,"paper_uid":"7b0e44fe-7cbf-41e5-9047-a246b9c5b9ac","identity_status":"available","lookup_basis":"semantic_scholar_external_id","compatibility_path":"corpus_id"},"url":"https://sah.borca.ai/papers/45619982"}