{"corpus_id":47828587,"paper_sha":"eef24aedb65def4543bbe9b45c88d8bffadc9114","doi":"10.1016/s0021-9258(18)72992-x","arxiv_id":null,"pmid":null,"pmcid":null,"mag_id":169193098,"dblp_id":null,"acl_id":null,"title":"INCREASED EXCRETION OF URINARY AMMONIA IN THE DOG FOLLOWING THE INTRAVENOUS INJECTION OF BOTH NATURAL AND UNNATURAL FORMS OF CERTAIN AMINO ACIDS","year":1941,"publication_date":null,"venue":"","journal":{"name":"Journal of Biological Chemistry","pages":"217-225","volume":"137"},"journal_issn":null,"journal_title":null,"publication_types":["Review"],"pubmed_pub_types":null,"s2_fields_of_study":["Biology","Medicine"],"reference_count":1,"citation_count":10,"influential_citation_count":0,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":null,"chemicals":null,"comments_corrections":null,"source_flags":1,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"The purpose of this investigation was to determine whether or not there would be an increased excretion of urinary ammonia when amino acids were furnished as precursors for this ammonia formation in addition to the amino acids already available in the blood stream. When it was found that there was increased ammonia elimination following the intravenous injection of amino acids, attention was direct.ed to the effectiveness of the natural and unnatural forms. Until recently the view has been held that tissue proteins yield only the I forms (Wohl-Freudenberg nomenclature) of amino acids on hydrolysis, and, under the circumstances, only these natural forms were thought of as being available for any reactions that amino acids might undergo in the animal body. This view was fortified by a large body of evidence which has been reviewed by Berg and Potgieter (1). They state, “It is obvious, therefore, that the unnatural component of a racemic modification of an amino acid is less readily attacked in the body than is the naturally occurring isomer.” These authors raised the question whether this difference in utilization is an absolute one or not. “Whether this difference in susceptibility to attack is sufficient to render effective utilization of an optical isomer impossible when only small amounts of its antipode are required (as, for example, in growth) may well be questioned.” Evidence has been accumulating to indicate that the animal","claims":[{"public_id":"cl_bec6cd0ac9ba86709a55f48ed8c2b9bf","status":"active","text":"Both natural and unnatural forms of certain amino acids can trigger increased urinary ammonia excretion.","confidence":0.93,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous 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