{"corpus_id":52173825,"paper_sha":"0f1777588112734f4cc64814c435c705f3a36b65","doi":"10.1021/acs.orglett.8b02421","arxiv_id":null,"pmid":30192556,"pmcid":null,"mag_id":2890704091,"dblp_id":null,"acl_id":null,"title":"Iridium-Catalyzed Reductive Nucleophilic Addition to Secondary Amides.","year":2018,"publication_date":"2018-09-07","venue":"Organic Letters","journal":{"name":"Organic letters","pages":"\n          5705-5708\n        ","volume":"20 18"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, Non-U.S. Gov't"],"s2_fields_of_study":["Medicine","Chemistry"],"reference_count":48,"citation_count":37,"influential_citation_count":0,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":null,"chemicals":null,"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"An iridium-catalyzed reductive nucleophilic addition to secondary amides is reported. After the iridium-catalyzed reduction, the resulting imines can undergo the Strecker reaction, the Mannich reaction, allylation, and [3 + 2]-cycloaddition. The method shows high chemoselectivity in the presence of other functional groups such as methyl ester.","claims":[{"public_id":"cl_e2093d569992258965b8ec59c8488c96","status":"active","text":"An iridium-catalyzed reductive nucleophilic addition to secondary amides is reported.","confidence":0.99,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_e2093d569992258965b8ec59c8488c96"},{"public_id":"cl_293df1511ef155e5af4a5372af8c6916","status":"active","text":"The method shows high chemoselectivity in the presence of other functional groups such as methyl ester.","confidence":0.92,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous 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