{"corpus_id":583709,"paper_sha":"0ff4e72975dadf2a9d9856be170e4cabf8d9cdb0","doi":"10.1038/nrd2422","arxiv_id":null,"pmid":18049472,"pmcid":"7097588","mag_id":2030739472,"dblp_id":null,"acl_id":null,"title":"Interferons at age 50: past, current and future impact on biomedicine","year":2007,"publication_date":"2007-12-01","venue":"Nature reviews. Drug discovery","journal":{"name":"Nature Reviews. 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Studies of IFNs have resulted in fundamental insights into cellular signalling mechanisms, gene transcription and innate and acquired immunity. Further elucidation of the multitude of IFN-induced genes, as well as drug development strategies targeting IFN production via the activation of the Toll-like receptors (TLRs), will almost certainly lead to newer and more efficacious therapeutics. 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