{"corpus_id":6435401,"paper_sha":"e275c966a5aa801b5d3fd4f8f8ada2f49ed65f9b","doi":"10.1152/PHYSREV.1999.79.4.1127","arxiv_id":null,"pmid":10508231,"pmcid":null,"mag_id":1920479129,"dblp_id":null,"acl_id":null,"title":"Mitochondrial transport of cations: channels, exchangers, and permeability transition.","year":1999,"publication_date":"1999-01-10","venue":"Physiological Reviews","journal":{"name":"Physiological reviews","pages":"\n          1127-55\n        ","volume":"79 4"},"journal_issn":null,"journal_title":null,"publication_types":["Review","JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, Non-U.S. Gov't","Research Support, U.S. Gov't, P.H.S.","Review"],"s2_fields_of_study":["Biology","Medicine","Chemistry"],"reference_count":380,"citation_count":1514,"influential_citation_count":114,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Calcium","mj":false,"qs":[{"q":"metabolism","mj":true,"ui":"Q000378"}],"ui":"D002118"},{"d":"Carrier Proteins","mj":false,"qs":[{"q":"metabolism","mj":true,"ui":"Q000378"}],"ui":"D002352"},{"d":"Cations","mj":false,"qs":[{"q":"metabolism","mj":true,"ui":"Q000378"}],"ui":"D002412"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Intracellular Membranes","mj":false,"qs":[{"q":"metabolism","mj":true,"ui":"Q000378"}],"ui":"D007425"},{"d":"Ion Channels","mj":false,"qs":[{"q":"metabolism","mj":true,"ui":"Q000378"}],"ui":"D007473"},{"d":"Magnesium","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D008274"},{"d":"Mitochondria","mj":false,"qs":[{"q":"metabolism","mj":true,"ui":"Q000378"}],"ui":"D008928"},{"d":"Permeability","mj":false,"ui":"D010539"},{"d":"Potassium","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D011188"}],"chemicals":[{"n":"Carrier Proteins","ui":"D002352","reg":"0"},{"n":"Cations","ui":"D002412","reg":"0"},{"n":"Ion Channels","ui":"D007473","reg":"0"},{"n":"Magnesium","ui":"D008274","reg":"I38ZP9992A"},{"n":"Potassium","ui":"D011188","reg":"RWP5GA015D"},{"n":"Calcium","ui":"D002118","reg":"SY7Q814VUP"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"This review provides a selective history of how studies of mitochondrial cation transport (K+, Na+, Ca2+) developed in relation to the major themes of research in bioenergetics. It then covers in some detail specific transport pathways for these cations, and it introduces and discusses open problems about their nature and physiological function, particularly in relation to volume regulation and Ca2+ homeostasis. The review should provide the basic elements needed to understand both earlier mitochondrial literature and current problems associated with mitochondrial transport of cations and hopefully will foster new interest in the molecular definition of mitochondrial cation channels and exchangers as well as their roles in cell physiology.","claims":[{"public_id":"cl_96710ff2ec8aebe706d3a77f2a5b6ffe","status":"active","text":"Mitochondrial cation transport of K+, Na+, and Ca2+ is central to bioenergetics, volume regulation, and Ca2+ homeostasis.","confidence":0.9,"contributors":[{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["extraction"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/claims/cl_96710ff2ec8aebe706d3a77f2a5b6ffe"}],"concepts":[{"public_id":"co_0720b31277dbe484cb2d08acb9d8c3ca","status":"active","name":"mitochondrial cation transport","description":"The movement of potassium, sodium, and calcium ions across the mitochondrial membrane.","types":["biological process"],"aliases":[],"contributors":[{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["extraction"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/concepts/co_0720b31277dbe484cb2d08acb9d8c3ca"},{"public_id":"co_a852209ad42ce9c0da82dd8b3bf8746d","status":"active","name":"volume regulation","description":"The maintenance of cell volume through ion and water flux regulation.","types":["biological process"],"aliases":[],"contributors":[{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["extraction"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/concepts/co_a852209ad42ce9c0da82dd8b3bf8746d"},{"public_id":"co_f1940c8acb39df8b1efccce61fb82694","status":"active","name":"bioenergetics","description":"The study of energy production and utilization in biological systems, particularly involving mitochondria.","types":["scientific field"],"aliases":[],"contributors":[{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["extraction"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/concepts/co_f1940c8acb39df8b1efccce61fb82694"},{"public_id":"co_fd867666066371dabb3202109c88636e","status":"active","name":"Ca2+ homeostasis","description":"The maintenance of stable intracellular calcium levels, heavily influenced by mitochondrial uptake and release.","types":["biological process"],"aliases":[],"contributors":[{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["extraction"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/concepts/co_fd867666066371dabb3202109c88636e"}],"external_ids":{"DOI":"10.1152/PHYSREV.1999.79.4.1127","ArXiv":null,"PubMed":10508231,"PubMedCentral":null,"MAG":1920479129,"DBLP":null,"ACL":null},"open_access":{"is_open_access":false,"pdf_url":null,"landing_url":"https://sah.borca.ai/papers/6435401","source":null,"pdf_url_source":null,"license":null,"reason":"pdf_url_not_indexed"},"reference_availability":{"status":"available","references_indexed":true,"full_text_available":false,"full_text_source":null,"count_basis":"semantic_scholar_metadata","extraction_status":"not_applicable","reason":null},"source":{"provider":"episteme2","base_corpus":"semantic_scholar_dump","freshness_mode":"unknown","basis":["semantic_scholar_metadata","postgres_metadata"],"limits":["paper metadata is based on indexed upstream scholarly datasets","claims and concepts are available only for extracted papers","absence of claims or concepts means no extracted graph data is available in this response"],"status":"available","degraded":false,"degraded_reasons":[],"diagnostics":{"status":"available","degraded":false,"degraded_reasons":[],"metadata_status":"available","graph_status":"available","abstract_status":"available"},"source_flags":5},"paper_id":630593,"paper_uid":"b60d9eec-07f0-4c71-9f1f-4932972da5f0","canonical_identity":{"paper_id":630593,"paper_uid":"b60d9eec-07f0-4c71-9f1f-4932972da5f0","identity_status":"available","lookup_basis":"semantic_scholar_external_id","compatibility_path":"corpus_id"},"url":"https://sah.borca.ai/papers/6435401"}