{"corpus_id":66989640,"paper_sha":"ee502e050db85368ebec8dd46f6d519650e8c9b8","doi":"10.1038/s41598-019-38558-y","arxiv_id":null,"pmid":30778117,"pmcid":"6379421","mag_id":2913171106,"dblp_id":null,"acl_id":null,"title":"Harnessing neurovascular interaction to guide axon growth","year":2019,"publication_date":"2019-02-18","venue":"Scientific Reports","journal":{"name":"Scientific Reports","pages":null,"volume":"9"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article","Research Support, Non-U.S. Gov't"],"s2_fields_of_study":["Medicine","Chemistry","Engineering"],"reference_count":51,"citation_count":21,"influential_citation_count":0,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Axon Guidance","mj":false,"qs":[{"q":"physiology","mj":true,"ui":"Q000502"}],"ui":"D000071437"},{"d":"Coculture Techniques","mj":false,"ui":"D018920"},{"d":"Disease Models, Animal","mj":false,"ui":"D004195"},{"d":"Endothelial Cells","mj":false,"qs":[{"q":"physiology","mj":false,"ui":"Q000502"}],"ui":"D042783"},{"d":"Female","mj":false,"ui":"D005260"},{"d":"Guided Tissue Regeneration","mj":false,"ui":"D048091"},{"d":"In Vitro Techniques","mj":false,"ui":"D066298"},{"d":"Microvessels","mj":false,"qs":[{"q":"growth & development","mj":false,"ui":"Q000254"},{"q":"physiology","mj":false,"ui":"Q000502"}],"ui":"D055806"},{"d":"Nerve Regeneration","mj":false,"qs":[{"q":"physiology","mj":true,"ui":"Q000502"}],"ui":"D009416"},{"d":"Neural Stem Cells","mj":false,"qs":[{"q":"physiology","mj":false,"ui":"Q000502"},{"q":"transplantation","mj":false,"ui":"Q000637"}],"ui":"D058953"},{"d":"Rats","mj":false,"ui":"D051381"},{"d":"Rats, Sprague-Dawley","mj":false,"ui":"D017207"},{"d":"Spinal Cord","mj":false,"qs":[{"q":"blood supply","mj":false,"ui":"Q000098"}],"ui":"D013116"},{"d":"Spinal Cord Injuries","mj":false,"qs":[{"q":"pathology","mj":false,"ui":"Q000473"},{"q":"physiopathology","mj":false,"ui":"Q000503"}],"ui":"D013119"},{"d":"Tissue Scaffolds","mj":false,"ui":"D054457"}],"chemicals":null,"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://www.nature.com/articles/s41598-019-38558-y.pdf","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/ee502e050db85368ebec8dd46f6d519650e8c9b8","s2_open_access_license":"CCBY","s2_open_access_status":"GOLD","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Regulating the intrinsic interactions between blood vessels and nerve cells has the potential to enhance repair and regeneration of the central nervous system. Here, we evaluate the efficacy of aligned microvessels to induce and control directional axon growth from neural progenitor cells in vitro and host axons in a rat spinal cord injury model. Interstitial fluid flow aligned microvessels generated from co-cultures of cerebral-derived endothelial cells and pericytes in a three-dimensional scaffold. The endothelial barrier function was evaluated by immunostaining for tight junction proteins and quantifying the permeability coefficient (~10−7 cm/s). Addition of neural progenitor cells to the co-culture resulted in the extension of Tuj-positive axons in the direction of the microvessels. To validate these findings in vivo, scaffolds were transplanted into an acute spinal cord hemisection injury with microvessels aligned with the rostral-caudal direction. At three weeks post-surgery, sagittal sections indicated close alignment between the host axons and the transplanted microvessels. Overall, this work demonstrates the efficacy of exploiting neurovascular interaction to direct axon growth in the injured spinal cord and the potential to use this strategy to facilitate central nervous system regeneration.","claims":[{"public_id":"cl_12934383c4e7e1a89d90d244f17601a3","status":"active","text":"Addition of neural progenitor cells to the co-culture caused Tuj-positive axons to extend in the direction of the microvessels.","confidence":0.95,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_12934383c4e7e1a89d90d244f17601a3"},{"public_id":"cl_c909b34eef603de7262d753c8ef63ba1","status":"active","text":"Aligned microvessels can induce and control directional axon growth from neural progenitor cells in vitro and host axons in a rat spinal cord injury model.","confidence":0.97,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_c909b34eef603de7262d753c8ef63ba1"},{"public_id":"cl_79ee8fcc52dacc64a75437e9b5e5244f","status":"active","text":"Exploiting neurovascular interaction provides a strategy to direct axon growth in the injured spinal cord and may facilitate central nervous system regeneration.","confidence":0.91,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_79ee8fcc52dacc64a75437e9b5e5244f"},{"public_id":"cl_45b7d079984982b8d35033c27cb5e13a","status":"active","text":"Interstitial fluid flow aligned microvessels generated from co-cultures of cerebral-derived endothelial cells and pericytes in a three-dimensional scaffold.","confidence":0.94,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_45b7d079984982b8d35033c27cb5e13a"},{"public_id":"cl_8e206b06858264c527f456ed0ebd4f43","status":"active","text":"Scaffolds transplanted into an acute spinal cord hemisection injury showed close alignment between host axons and transplanted microvessels at three weeks post-surgery.","confidence":0.96,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_8e206b06858264c527f456ed0ebd4f43"}],"concepts":[{"public_id":"co_079facdfa50f1ede0689c534dfa2afca","status":"active","name":"three-dimensional scaffold","description":"A 3D matrix used to support co-culture and microvessel assembly.","types":["biomaterial scaffold"],"aliases":["3D 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