{"corpus_id":676984,"paper_sha":"2f159775928d54b8679f128b954bb1b32894060a","doi":"10.3389/fnhum.2013.00232","arxiv_id":null,"pmid":23755001,"pmcid":"3665907","mag_id":2152273217,"dblp_id":null,"acl_id":null,"title":"Segregation of the human medial prefrontal cortex in social cognition","year":2013,"publication_date":"2013-04-03","venue":"Frontiers in Human Neuroscience","journal":{"name":"Frontiers in Human Neuroscience","pages":null,"volume":"7"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article"],"s2_fields_of_study":["Medicine","Psychology"],"reference_count":156,"citation_count":215,"influential_citation_count":12,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":null,"chemicals":null,"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://www.frontiersin.org/articles/10.3389/fnhum.2013.00232/pdf","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/2f159775928d54b8679f128b954bb1b32894060a","s2_open_access_license":"CCBY","s2_open_access_status":"GOLD","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"While the human medial prefrontal cortex (mPFC) is widely believed to be a key node of neural networks relevant for socio-emotional processing, its functional subspecialization is still poorly understood. We thus revisited the often assumed differentiation of the mPFC in social cognition along its ventral-dorsal axis. Our neuroinformatic analysis was based on a neuroimaging meta-analysis of perspective-taking that yielded two separate clusters in the ventral and dorsal mPFC, respectively. We determined each seed region's brain-wide interaction pattern by two complementary measures of functional connectivity: co-activation across a wide range of neuroimaging studies archived in the BrainMap database and correlated signal fluctuations during unconstrained (“resting”) cognition. Furthermore, we characterized the functions associated with these two regions using the BrainMap database. Across methods, the ventral mPFC was more strongly connected with the nucleus accumbens, hippocampus, posterior cingulate cortex, and retrosplenial cortex, while the dorsal mPFC was more strongly connected with the inferior frontal gyrus, temporo-parietal junction, and middle temporal gyrus. Further, the ventral mPFC was selectively associated with reward related tasks, while the dorsal mPFC was selectively associated with perspective-taking and episodic memory retrieval. The ventral mPFC is therefore predominantly involved in bottom-up-driven, approach/avoidance-modulating, and evaluation-related processing, whereas the dorsal mPFC is predominantly involved in top–down-driven, probabilistic-scene-informed, and metacognition-related processing in social cognition.","claims":[{"public_id":"cl_f5e754eb4912df1c0f2f1cb932b85532","status":"active","text":"A neuroinformatic analysis of perspective-taking identified separate ventral and dorsal medial prefrontal cortex clusters and characterized their brain-wide interaction patterns using functional connectivity measures.","confidence":0.93,"contributors":[{"id":35,"public_id":"b2adb6bfad","public_label":"Anonymous (b2adb6bfad)","roles":["extraction"],"url":"https://sah.borca.ai/u/b2adb6bfad"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/claims/cl_f5e754eb4912df1c0f2f1cb932b85532"},{"public_id":"cl_ae7c83e095a8b8165d009b9d2b14996a","status":"active","text":"The dorsal mPFC was more strongly connected with regions including the inferior frontal gyrus, temporo-parietal junction, and middle temporal gyrus across the connectivity methods.","confidence":0.95,"contributors":[{"id":35,"public_id":"b2adb6bfad","public_label":"Anonymous (b2adb6bfad)","roles":["extraction"],"url":"https://sah.borca.ai/u/b2adb6bfad"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/claims/cl_ae7c83e095a8b8165d009b9d2b14996a"},{"public_id":"cl_f99756e8f810261f1a19faa7a37fac46","status":"active","text":"The ventral mPFC is predominantly involved in bottom-up-driven evaluation-related processing, while the dorsal mPFC is predominantly involved in top-down-driven metacognition-related processing in social cognition.","confidence":0.9,"contributors":[{"id":35,"public_id":"b2adb6bfad","public_label":"Anonymous (b2adb6bfad)","roles":["extraction"],"url":"https://sah.borca.ai/u/b2adb6bfad"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/claims/cl_f99756e8f810261f1a19faa7a37fac46"},{"public_id":"cl_945a6e70c51086bbdcb2dd620aebe983","status":"active","text":"The ventral mPFC was more strongly connected with regions including the nucleus accumbens, hippocampus, posterior cingulate cortex, and retrosplenial cortex across the connectivity methods.","confidence":0.95,"contributors":[{"id":35,"public_id":"b2adb6bfad","public_label":"Anonymous (b2adb6bfad)","roles":["extraction"],"url":"https://sah.borca.ai/u/b2adb6bfad"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/claims/cl_945a6e70c51086bbdcb2dd620aebe983"},{"public_id":"cl_261a465010672b93bc367b6d8a875394","status":"active","text":"The ventral mPFC was selectively associated with reward related tasks, whereas the dorsal mPFC was selectively associated with perspective-taking and episodic memory retrieval.","confidence":0.95,"contributors":[{"id":35,"public_id":"b2adb6bfad","public_label":"Anonymous (b2adb6bfad)","roles":["extraction"],"url":"https://sah.borca.ai/u/b2adb6bfad"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/claims/cl_261a465010672b93bc367b6d8a875394"}],"concepts":[{"public_id":"co_0c8a2e927eaef8a6ca97b13ecaf6d77a","status":"active","name":"nucleus accumbens","description":"A brain region included among the connectivity targets compared for medial prefrontal cortex subdivisions.","types":["brain region"],"aliases":[],"contributors":[{"id":35,"public_id":"b2adb6bfad","public_label":"Anonymous (b2adb6bfad)","roles":["extraction"],"url":"https://sah.borca.ai/u/b2adb6bfad"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/concepts/co_0c8a2e927eaef8a6ca97b13ecaf6d77a"},{"public_id":"co_40b1a80e4293087ee9bf7da51e0ec5f9","status":"active","name":"temporo-parietal junction","description":"A cortical region included among the connectivity targets compared for medial prefrontal cortex subdivisions.","types":["brain region"],"aliases":[],"contributors":[{"id":35,"public_id":"b2adb6bfad","public_label":"Anonymous (b2adb6bfad)","roles":["extraction"],"url":"https://sah.borca.ai/u/b2adb6bfad"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/concepts/co_40b1a80e4293087ee9bf7da51e0ec5f9"},{"public_id":"co_44eee159b3a34b90306cc079bb4ff31e","status":"active","name":"social cognition","description":"A domain of cognition involving socio-emotional processing and perspective-related mental operations.","types":["cognitive domain"],"aliases":[],"contributors":[{"id":35,"public_id":"b2adb6bfad","public_label":"Anonymous (b2adb6bfad)","roles":["extraction"],"url":"https://sah.borca.ai/u/b2adb6bfad"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/concepts/co_44eee159b3a34b90306cc079bb4ff31e"},{"public_id":"co_4672742fa08445f5f1f5d5bf4138920e","status":"active","name":"reward related tasks","description":"Tasks involving reward processing used to characterize functional associations of medial prefrontal cortex regions.","types":["task domain"],"aliases":[],"contributors":[{"id":35,"public_id":"b2adb6bfad","public_label":"Anonymous (b2adb6bfad)","roles":["extraction"],"url":"https://sah.borca.ai/u/b2adb6bfad"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/concepts/co_4672742fa08445f5f1f5d5bf4138920e"},{"public_id":"co_61035bad991c62a1d464b774423c7a21","status":"active","name":"functional connectivity","description":"Measures of brain-wide interaction patterns based on co-activation and correlated signal fluctuations.","types":["measurement approach"],"aliases":[],"contributors":[{"id":35,"public_id":"b2adb6bfad","public_label":"Anonymous (b2adb6bfad)","roles":["extraction"],"url":"https://sah.borca.ai/u/b2adb6bfad"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/concepts/co_61035bad991c62a1d464b774423c7a21"},{"public_id":"co_9b6753f0951d31128cdd929cdbdecf9d","status":"active","name":"BrainMap database","description":"A database of archived neuroimaging studies used for co-activation analysis and functional characterization.","types":["database"],"aliases":[],"contributors":[{"id":35,"public_id":"b2adb6bfad","public_label":"Anonymous (b2adb6bfad)","roles":["extraction"],"url":"https://sah.borca.ai/u/b2adb6bfad"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/concepts/co_9b6753f0951d31128cdd929cdbdecf9d"},{"public_id":"co_bd4bbaea6b2a7dc6b0cce6ae946ce2e1","status":"active","name":"human medial prefrontal cortex","description":"A medial prefrontal brain region examined for functional subspecialization in socio-emotional processing.","types":["brain region"],"aliases":["mPFC"],"contributors":[{"id":35,"public_id":"b2adb6bfad","public_label":"Anonymous (b2adb6bfad)","roles":["extraction"],"url":"https://sah.borca.ai/u/b2adb6bfad"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/concepts/co_bd4bbaea6b2a7dc6b0cce6ae946ce2e1"},{"public_id":"co_d3e43ffa18798e55bf88507e21eb086c","status":"active","name":"perspective-taking","description":"A social-cognitive task domain used to derive medial prefrontal cortex clusters in the neuroimaging meta-analysis.","types":["cognitive process"],"aliases":[],"contributors":[{"id":35,"public_id":"b2adb6bfad","public_label":"Anonymous (b2adb6bfad)","roles":["extraction"],"url":"https://sah.borca.ai/u/b2adb6bfad"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/concepts/co_d3e43ffa18798e55bf88507e21eb086c"},{"public_id":"co_d92bcb9e8d771e295b5578e6c08fb685","status":"active","name":"hippocampus","description":"A brain region included among the connectivity targets compared for medial prefrontal cortex subdivisions.","types":["brain region"],"aliases":[],"contributors":[{"id":35,"public_id":"b2adb6bfad","public_label":"Anonymous (b2adb6bfad)","roles":["extraction"],"url":"https://sah.borca.ai/u/b2adb6bfad"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/concepts/co_d92bcb9e8d771e295b5578e6c08fb685"},{"public_id":"co_e8706ce2c8e177d6650fb294a1a4b1d1","status":"active","name":"neuroinformatic analysis","description":"A computational analysis approach used to combine neuroimaging meta-analysis, connectivity measures, and functional characterization.","types":["method"],"aliases":[],"contributors":[{"id":35,"public_id":"b2adb6bfad","public_label":"Anonymous (b2adb6bfad)","roles":["extraction"],"url":"https://sah.borca.ai/u/b2adb6bfad"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/concepts/co_e8706ce2c8e177d6650fb294a1a4b1d1"},{"public_id":"co_ee0abd71524a0a35fc53fa5c0f689d28","status":"active","name":"inferior frontal gyrus","description":"A frontal brain region included among the connectivity targets compared for medial prefrontal cortex subdivisions.","types":["brain region"],"aliases":[],"contributors":[{"id":35,"public_id":"b2adb6bfad","public_label":"Anonymous (b2adb6bfad)","roles":["extraction"],"url":"https://sah.borca.ai/u/b2adb6bfad"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/concepts/co_ee0abd71524a0a35fc53fa5c0f689d28"},{"public_id":"co_efba3f620321cdeeb6deee0360120394","status":"active","name":"ventral mPFC","description":"The ventral medial prefrontal cortex seed region analyzed as one subdivision of the human medial prefrontal cortex.","types":["brain region"],"aliases":[],"contributors":[{"id":35,"public_id":"b2adb6bfad","public_label":"Anonymous (b2adb6bfad)","roles":["extraction"],"url":"https://sah.borca.ai/u/b2adb6bfad"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/concepts/co_efba3f620321cdeeb6deee0360120394"},{"public_id":"co_ff142fde00de229df28cc0eca5bf5608","status":"active","name":"dorsal mPFC","description":"The dorsal medial prefrontal cortex seed region analyzed as one subdivision of the human medial prefrontal cortex.","types":["brain region"],"aliases":[],"contributors":[{"id":35,"public_id":"b2adb6bfad","public_label":"Anonymous (b2adb6bfad)","roles":["extraction"],"url":"https://sah.borca.ai/u/b2adb6bfad"},{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["review"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":17,"public_id":"322360f1c1","public_label":"Killer Whale (322360f1c1)","roles":["review"],"url":"https://sah.borca.ai/u/322360f1c1"}],"url":"https://sah.borca.ai/concepts/co_ff142fde00de229df28cc0eca5bf5608"}],"external_ids":{"DOI":"10.3389/fnhum.2013.00232","ArXiv":null,"PubMed":23755001,"PubMedCentral":"3665907","MAG":2152273217,"DBLP":null,"ACL":null},"open_access":{"is_open_access":true,"pdf_url":"https://www.frontiersin.org/articles/10.3389/fnhum.2013.00232/pdf","landing_url":"https://www.semanticscholar.org/paper/2f159775928d54b8679f128b954bb1b32894060a","source":"semantic_scholar","pdf_url_source":"semantic_scholar_open_access_pdf","license":"CCBY","status":"GOLD","reason":null},"reference_availability":{"status":"available","references_indexed":true,"full_text_available":false,"full_text_source":null,"count_basis":"semantic_scholar_metadata","extraction_status":"not_applicable","reason":null},"source":{"provider":"episteme2","base_corpus":"semantic_scholar_dump","freshness_mode":"unknown","basis":["semantic_scholar_metadata","postgres_metadata"],"limits":["paper metadata is based on indexed upstream scholarly datasets","claims and concepts are available only for extracted papers","absence of claims or concepts means no extracted graph data is available in this response"],"status":"available","degraded":false,"degraded_reasons":[],"diagnostics":{"status":"available","degraded":false,"degraded_reasons":[],"metadata_status":"available","graph_status":"available","abstract_status":"available"},"source_flags":5},"paper_id":630644,"paper_uid":"36d51ecc-ebd2-472a-8fa0-c27c8f249ba4","canonical_identity":{"paper_id":630644,"paper_uid":"36d51ecc-ebd2-472a-8fa0-c27c8f249ba4","identity_status":"available","lookup_basis":"semantic_scholar_external_id","compatibility_path":"corpus_id"},"url":"https://sah.borca.ai/papers/676984"}