{"corpus_id":680335,"paper_sha":"417ef03bd88c117fa314c94586962778bfd3f79a","doi":"10.1016/0012-1606(71)90109-6","arxiv_id":null,"pmid":5000057,"pmcid":null,"mag_id":2041793696,"dblp_id":null,"acl_id":null,"title":"Aldehyde oxidase in Drosophila melanogaster: a system for genetic studies on developmental regulation.","year":1971,"publication_date":"1971-09-01","venue":"Developmental Biology","journal":{"name":"Developmental biology","pages":"\n          77-86\n        ","volume":"26 1"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article"],"s2_fields_of_study":["Biology","Medicine"],"reference_count":20,"citation_count":51,"influential_citation_count":1,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Aldehydes","mj":false,"ui":"D000447"},{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Culture Techniques","mj":false,"ui":"D046508"},{"d":"Drosophila melanogaster","mj":false,"qs":[{"q":"cytology","mj":false,"ui":"Q000166"},{"q":"enzymology","mj":true,"ui":"Q000201"},{"q":"growth & development","mj":false,"ui":"Q000254"}],"ui":"D004331"},{"d":"Female","mj":false,"ui":"D005260"},{"d":"Histocytochemistry","mj":false,"ui":"D006651"},{"d":"Larva","mj":false,"qs":[{"q":"enzymology","mj":false,"ui":"Q000201"}],"ui":"D007814"},{"d":"Male","mj":false,"ui":"D008297"},{"d":"Morphogenesis","mj":false,"ui":"D009024"},{"d":"Mutation","mj":false,"ui":"D009154"},{"d":"Ovary","mj":false,"qs":[{"q":"enzymology","mj":false,"ui":"Q000201"}],"ui":"D010053"},{"d":"Ovum","mj":false,"ui":"D010063"},{"d":"Oxidoreductases","mj":false,"qs":[{"q":"biosynthesis","mj":true,"ui":"Q000096"}],"ui":"D010088"},{"d":"Time Factors","mj":false,"ui":"D013997"}],"chemicals":[{"n":"Aldehydes","ui":"D000447","reg":"0"},{"n":"Oxidoreductases","ui":"D010088","reg":"EC 1.-"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://zenodo.org/records/10742199/files/Dickinson,%201971.pdf","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/417ef03bd88c117fa314c94586962778bfd3f79a","s2_open_access_license":"CCBY","s2_open_access_status":"GREEN","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Abstract The enzyme aldehyde oxidase in Drosophila melanogaster has been examined with respect to the normal pattern of developmental regulation and differentiation. Genetic evidence indicates that synthesis begins earlier than previously believed, but not until after hatching of the egg. The overall developmental curve is reproducible for a given strain of Drosophila . The differentiated tissue distribution in both larvae and adults is very precise and discontinuous and is also highly reproducible for a given strain. Both quantitative and histochemical determinations of the distribution are given. Synthesis of the enzyme is shown to be autonomous, at least in ovaries. We conclude that this enzyme provides a suitable case for seeking mutations that affect differentiated expression of a single, specific gene product (i.e., mutations causing altered developmental pattern or altered tissue specificity). The basis of observed strain specific variation in aldehyde oxidase expression is being investigated, and new variants are being sought.","claims":[{"public_id":"cl_0e6448b925c4faf7ac610e77bd6cea83","status":"active","text":"Aldehyde oxidase is a suitable system for identifying mutations that alter developmental pattern or tissue specificity of a single gene product.","confidence":0.93,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_0e6448b925c4faf7ac610e77bd6cea83"},{"public_id":"cl_3ecab7ca5783872516999f741cd11eeb","status":"active","text":"Aldehyde oxidase shows a precise, discontinuous, and highly reproducible tissue distribution in larvae and adults of a given strain.","confidence":0.95,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous 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