{"corpus_id":6834738,"paper_sha":"1ebde1cce4ba96a08190e10a8d7aabd3e3a0e780","doi":"10.3390/nu9040349","arxiv_id":null,"pmid":28368310,"pmcid":"5409688","mag_id":2604907975,"dblp_id":null,"acl_id":null,"title":"Role of the Enterocyte in Fructose-Induced Hypertriglyceridaemia","year":2017,"publication_date":"2017-04-01","venue":"Nutrients","journal":{"name":"Nutrients","pages":null,"volume":"9"},"journal_issn":null,"journal_title":null,"publication_types":["Review","JournalArticle"],"pubmed_pub_types":["Journal Article","Review"],"s2_fields_of_study":["Biology","Medicine"],"reference_count":93,"citation_count":22,"influential_citation_count":0,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Chylomicrons","mj":false,"qs":[{"q":"blood","mj":false,"ui":"Q000097"},{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D002914"},{"d":"Dietary Carbohydrates","mj":false,"qs":[{"q":"adverse effects","mj":true,"ui":"Q000009"},{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D004040"},{"d":"Enterocytes","mj":false,"qs":[{"q":"metabolism","mj":true,"ui":"Q000378"},{"q":"pathology","mj":false,"ui":"Q000473"}],"ui":"D020895"},{"d":"Fructose","mj":false,"qs":[{"q":"adverse effects","mj":true,"ui":"Q000009"},{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D005632"},{"d":"Hepatocytes","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"},{"q":"pathology","mj":false,"ui":"Q000473"}],"ui":"D022781"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Hypertriglyceridemia","mj":false,"qs":[{"q":"blood","mj":false,"ui":"Q000097"},{"q":"etiology","mj":false,"ui":"Q000209"},{"q":"metabolism","mj":false,"ui":"Q000378"},{"q":"pathology","mj":true,"ui":"Q000473"}],"ui":"D015228"},{"d":"Intestine, Small","mj":false,"qs":[{"q":"metabolism","mj":false,"ui":"Q000378"},{"q":"pathology","mj":true,"ui":"Q000473"}],"ui":"D007421"},{"d":"Lipogenesis","mj":false,"ui":"D050155"},{"d":"Lipoproteins","mj":false,"qs":[{"q":"blood","mj":false,"ui":"Q000097"},{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D008074"},{"d":"Lipoproteins, VLDL","mj":false,"qs":[{"q":"blood","mj":false,"ui":"Q000097"},{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D008079"},{"d":"Models, Biological","mj":true,"ui":"D008954"},{"d":"Triglycerides","mj":false,"qs":[{"q":"blood","mj":false,"ui":"Q000097"},{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D014280"}],"chemicals":[{"n":"Chylomicrons","ui":"D002914","reg":"0"},{"n":"Dietary Carbohydrates","ui":"D004040","reg":"0"},{"n":"Lipoproteins","ui":"D008074","reg":"0"},{"n":"Lipoproteins, VLDL","ui":"D008079","reg":"0"},{"n":"Triglycerides","ui":"D014280","reg":"0"},{"n":"Fructose","ui":"D005632","reg":"30237-26-4"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://www.mdpi.com/2072-6643/9/4/349/pdf?version=1491382646","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/1ebde1cce4ba96a08190e10a8d7aabd3e3a0e780","s2_open_access_license":"CCBY","s2_open_access_status":"GOLD","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Dietary fructose has been linked to an increased post-prandial triglyceride (TG) level; which is an established independent risk factor for cardiovascular disease. Although much research has focused on the effects of fructose consumption on liver-derived very-low density lipoprotein (VLDL); emerging evidence also suggests that fructose may raise post-prandial TG levels by affecting the metabolism of enterocytes of the small intestine. Enterocytes have become well recognised for their ability to transiently store lipids following a meal and to thus control post-prandial TG levels according to the rate of chylomicron (CM) lipoprotein synthesis and secretion. The influence of fructose consumption on several aspects of enterocyte lipid metabolism are discussed; including de novo lipogenesis; apolipoprotein B48 and CM-TG production; based on the findings of animal and human isotopic tracer studies. Methodological issues affecting the interpretation of fructose studies conducted to date are highlighted; including the accurate separation of CM and VLDL. Although the available evidence to date is limited; disruption of enterocyte lipid metabolism may make a meaningful contribution to the hypertriglyceridaemia often associated with fructose consumption.","claims":[{"public_id":"cl_bb33899c1106a29af3a71d6709538c3d","status":"active","text":"Accurate separation of chylomicrons and very-low density lipoprotein is highlighted as a methodological issue affecting interpretation of fructose studies.","confidence":0.89,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_bb33899c1106a29af3a71d6709538c3d"},{"public_id":"cl_1e9f7066258ae56e9cad436989fc8082","status":"active","text":"Disruption of enterocyte lipid metabolism may make a meaningful contribution to the hypertriglyceridaemia associated with fructose 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