{"corpus_id":71307539,"paper_sha":"ffade339886f79b109c17273cc234c4895ae4a04","doi":"10.1590/S0482-50042005000400007","arxiv_id":null,"pmid":null,"pmcid":null,"mag_id":2007214341,"dblp_id":null,"acl_id":null,"title":"Transplante de células-tronco hematopoéticas em doenças reumáticas parte 1: experiência internacional","year":2005,"publication_date":"2005-08-01","venue":"","journal":{"name":"Revista Brasileira De Reumatologia","pages":"229-241","volume":"45"},"journal_issn":null,"journal_title":null,"publication_types":["Review"],"pubmed_pub_types":null,"s2_fields_of_study":["Medicine"],"reference_count":52,"citation_count":9,"influential_citation_count":0,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":null,"chemicals":null,"comments_corrections":null,"source_flags":1,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"In this review, we discuss the results of hematopoietic stem cell transplantation (HSCT) for severe and refractory rheumatic diseases performed abroad. We briefly review clinical and experimental basis for those transplants and the international results obtained in systemic lupus erythematosus (SLE) (33/50 complete remissions in the European registry with 10 relapses and 12 deaths, and 41 durable remissions in an American study with 2 deaths post-mobilisation and 4 deaths posttransplantation), adult rheumatoid arthritis (58/73 partial remissions with 85% of relapses and only one death in the European registry), juvenile idiopathic arthritis (18/34 durable remissions and 5 deaths in the European registry), systemic sclerosis (SSc) (46/50 responders in a multicentric European study with 35% of relapses and 23% of mortality, while in an US series, 4/19 patients died, 2 had progressive lung disease and all the survivors improved the skin scores and quality of life) and several other diseases, including vasculidities (9/15 complete responses in the European registry). We conclude that in the international experience, autologous HSCT induces sustained remission in most severe and refractory rheumatic diseases except for adult rheumatoid arthritis, and this finding justifies starting prospective randomized trials of HSCT compared to optimal conventional therapy.","claims":[{"public_id":"cl_294a6efc987acfe9fbded92f6d115107","status":"active","text":"Adult rheumatoid arthritis is the main exception to the overall remission pattern, with frequent relapses after transplantation.","confidence":0.92,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_294a6efc987acfe9fbded92f6d115107"},{"public_id":"cl_89019348730afc1bf72f230abeeb4416","status":"active","text":"Autologous hematopoietic stem cell transplantation induces sustained remission in most severe and refractory rheumatic diseases in the international experience.","confidence":0.96,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_89019348730afc1bf72f230abeeb4416"},{"public_id":"cl_b59231ba987e206098e1f141de56479d","status":"active","text":"Prospective randomized trials comparing hematopoietic stem cell transplantation with optimal conventional therapy are justified.","confidence":0.89,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_b59231ba987e206098e1f141de56479d"},{"public_id":"cl_2b98cc22d4ac25f58f55c603f9e88fe9","status":"active","text":"The reported international results include substantial complete or durable remission rates in systemic lupus erythematosus, juvenile idiopathic arthritis, systemic sclerosis, and vasculitides.","confidence":0.95,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_2b98cc22d4ac25f58f55c603f9e88fe9"}],"concepts":[{"public_id":"co_28bf84dbbcb617b8df6840b9458314a4","status":"active","name":"hematopoietic stem cell transplantation","description":"A transplant procedure that replaces or resets hematopoietic stem cells through collection, conditioning, and infusion.","types":["treatment"],"aliases":["HSCT"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_28bf84dbbcb617b8df6840b9458314a4"},{"public_id":"co_3451340dffc7ab9dea03b3843df0c268","status":"active","name":"vasculitides","description":"Inflammatory diseases of blood vessels.","types":["disease 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