{"corpus_id":765530,"paper_sha":"c70fdf1eefc80a1190de34b31e0268aed98b3356","doi":"10.1084/JEM.183.6.2593","arxiv_id":null,"pmid":8676080,"pmcid":"2192621","mag_id":2158854771,"dblp_id":null,"acl_id":null,"title":"T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines","year":1996,"publication_date":"1996-06-01","venue":"Journal of Experimental Medicine","journal":{"name":"The Journal of Experimental Medicine","pages":"2593 - 2603","volume":"183"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle","Study"],"pubmed_pub_types":["Comparative Study","Journal Article"],"s2_fields_of_study":["Biology","Medicine"],"reference_count":42,"citation_count":1717,"influential_citation_count":76,"is_open_access":true,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Amino Acid Sequence","mj":false,"ui":"D000595"},{"d":"Animals","mj":false,"ui":"D000818"},{"d":"Arthritis, Rheumatoid","mj":false,"qs":[{"q":"immunology","mj":false,"ui":"Q000276"}],"ui":"D001172"},{"d":"Base Sequence","mj":false,"ui":"D001483"},{"d":"Cytokines","mj":false,"qs":[{"q":"biosynthesis","mj":true,"ui":"Q000096"}],"ui":"D016207"},{"d":"Dinoprostone","mj":false,"qs":[{"q":"biosynthesis","mj":false,"ui":"Q000096"}],"ui":"D015232"},{"d":"Endothelium, Vascular","mj":false,"qs":[{"q":"drug effects","mj":false,"ui":"Q000187"},{"q":"immunology","mj":true,"ui":"Q000276"}],"ui":"D004730"},{"d":"Fibroblasts","mj":false,"qs":[{"q":"immunology","mj":false,"ui":"Q000276"}],"ui":"D005347"},{"d":"Granulocyte Colony-Stimulating Factor","mj":false,"qs":[{"q":"biosynthesis","mj":false,"ui":"Q000096"}],"ui":"D016179"},{"d":"Hematopoiesis","mj":false,"ui":"D006410"},{"d":"Hematopoietic Stem Cells","mj":false,"qs":[{"q":"drug effects","mj":false,"ui":"Q000187"},{"q":"immunology","mj":true,"ui":"Q000276"}],"ui":"D006412"},{"d":"Herpesvirus 2, Saimiriine","mj":false,"qs":[{"q":"genetics","mj":false,"ui":"Q000235"},{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D006567"},{"d":"Humans","mj":false,"ui":"D006801"},{"d":"Inflammation","mj":false,"ui":"D007249"},{"d":"Interferon-gamma","mj":false,"qs":[{"q":"pharmacology","mj":false,"ui":"Q000494"}],"ui":"D007371"},{"d":"Interleukin-17","mj":false,"ui":"D020381"},{"d":"Interleukin-6","mj":false,"qs":[{"q":"biosynthesis","mj":false,"ui":"Q000096"}],"ui":"D015850"},{"d":"Interleukin-8","mj":false,"qs":[{"q":"biosynthesis","mj":false,"ui":"Q000096"}],"ui":"D016209"},{"d":"Interleukins","mj":false,"qs":[{"q":"biosynthesis","mj":true,"ui":"Q000096"},{"q":"chemistry","mj":false,"ui":"Q000737"},{"q":"immunology","mj":false,"ui":"Q000276"}],"ui":"D007378"},{"d":"Lymphocytes","mj":false,"qs":[{"q":"immunology","mj":false,"ui":"Q000276"}],"ui":"D008214"},{"d":"Macromolecular Substances","mj":false,"ui":"D046911"},{"d":"Mice","mj":false,"ui":"D051379"},{"d":"Molecular Sequence Data","mj":false,"ui":"D008969"},{"d":"Open Reading Frames","mj":false,"ui":"D016366"},{"d":"Recombinant Proteins","mj":false,"qs":[{"q":"biosynthesis","mj":false,"ui":"Q000096"}],"ui":"D011994"},{"d":"Reference Values","mj":false,"ui":"D012016"},{"d":"Sequence Homology, Amino Acid","mj":false,"ui":"D017386"},{"d":"Skin","mj":false,"qs":[{"q":"immunology","mj":false,"ui":"Q000276"}],"ui":"D012867"},{"d":"Stromal Cells","mj":false,"qs":[{"q":"drug effects","mj":false,"ui":"Q000187"},{"q":"immunology","mj":false,"ui":"Q000276"}],"ui":"D017154"},{"d":"Synovial Membrane","mj":false,"qs":[{"q":"immunology","mj":false,"ui":"Q000276"}],"ui":"D013583"},{"d":"T-Lymphocytes","mj":false,"qs":[{"q":"immunology","mj":true,"ui":"Q000276"}],"ui":"D013601"},{"d":"Transfection","mj":false,"ui":"D014162"},{"d":"Tumor Necrosis Factor-alpha","mj":false,"qs":[{"q":"pharmacology","mj":false,"ui":"Q000494"}],"ui":"D014409"},{"d":"Viral Proteins","mj":false,"qs":[{"q":"biosynthesis","mj":false,"ui":"Q000096"},{"q":"chemistry","mj":false,"ui":"Q000737"}],"ui":"D014764"}],"chemicals":[{"n":"Cytokines","ui":"D016207","reg":"0"},{"n":"Interleukin-17","ui":"D020381","reg":"0"},{"n":"Interleukin-6","ui":"D015850","reg":"0"},{"n":"Interleukin-8","ui":"D016209","reg":"0"},{"n":"Interleukins","ui":"D007378","reg":"0"},{"n":"Macromolecular Substances","ui":"D046911","reg":"0"},{"n":"ORF13 protein, Herpesvirus saimiri","ui":"C100346","reg":"0"},{"n":"Recombinant Proteins","ui":"D011994","reg":"0"},{"n":"Tumor Necrosis Factor-alpha","ui":"D014409","reg":"0"},{"n":"Viral Proteins","ui":"D014764","reg":"0"},{"n":"Granulocyte Colony-Stimulating Factor","ui":"D016179","reg":"143011-72-7"},{"n":"Interferon-gamma","ui":"D007371","reg":"82115-62-6"},{"n":"Dinoprostone","ui":"D015232","reg":"K7Q1JQR04M"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":"https://rupress.org/jem/article-pdf/183/6/2593/1108210/2593.pdf","s2_open_access_landing_url":"https://www.semanticscholar.org/paper/c70fdf1eefc80a1190de34b31e0268aed98b3356","s2_open_access_license":"CCBYNCSA","s2_open_access_status":"BRONZE","pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Analysis of the cDNA encoding murine interleukin (IL) 17 (cytotoxic T lymphocyte associated antigen 8) predicted a secreted protein sharing 57% amino acid identity with the protein predicted from ORF13, an open reading frame of Herpesvirus saimiri. Here we report on the cloning of human IL-17 (hIL-17), the human counterpart of murine IL-17. hIL-17 is a glycoprotein of 155 amino acids secreted as an homodimer by activated memory CD4+ T cells. Although devoid of direct effects on cells of hematopoietic origin, hIL-17 and the product of its viral counterpart, ORF13, stimulate epithelial, endothelial, and fibroblastic cells to secrete cytokines such as IL-6, IL-8, and granulocyte-colony- stimulating factor, as well as prostaglandin E2. Furthermore, when cultured in the presence of hIL-17, fibroblasts could sustain the proliferation of CD34+ hematopoietic progenitors and their preferential maturation into neutrophils. These observations suggest that hIL-17 may constitute (a) an early initiator of the T cell-dependent inflammmatory reaction; and (b) an element of the cytokine network that bridges the immune system to hematopoiesis.","claims":[{"public_id":"cl_3f6aaf22e3a7ea658110274f142e74fa","status":"active","text":"Human interleukin-17 and herpesvirus saimiri ORF13 stimulate epithelial, endothelial, and fibroblastic cells to secrete IL-6, IL-8, granulocyte-colony stimulating factor, and prostaglandin E2.","confidence":0.97,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_3f6aaf22e3a7ea658110274f142e74fa"},{"public_id":"cl_86dade4267ab55d3aee112852257a802","status":"active","text":"Human interleukin-17 has no direct effects on cells of hematopoietic origin.","confidence":0.94,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_86dade4267ab55d3aee112852257a802"},{"public_id":"cl_fc97763491b0eff45daf18c5a9438651","status":"active","text":"Human interleukin-17 is a 155-amino-acid glycoprotein secreted as a homodimer by activated memory CD4+ T cells.","confidence":0.98,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_fc97763491b0eff45daf18c5a9438651"},{"public_id":"cl_8da97f4c1b71fea9290357c83bdf9251","status":"active","text":"Human interleukin-17 may act as an early initiator of T cell-dependent inflammatory reactions and as a bridge between the immune system and hematopoiesis.","confidence":0.9,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_8da97f4c1b71fea9290357c83bdf9251"},{"public_id":"cl_05158b1c091ec7506f8cf192fea0799b","status":"active","text":"In the presence of human interleukin-17, fibroblasts support proliferation of CD34+ hematopoietic progenitors and their preferential maturation into neutrophils.","confidence":0.96,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_05158b1c091ec7506f8cf192fea0799b"}],"concepts":[{"public_id":"co_084bc35a9dc60a04fee1e80ae4ac8eb5","status":"active","name":"homodimer","description":"A protein complex composed of two identical subunits.","types":["molecular form"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_084bc35a9dc60a04fee1e80ae4ac8eb5"},{"public_id":"co_0dc4e92382f0c86edaac8c0980393ea9","status":"active","name":"granulocyte-colony stimulating factor","description":"A hematopoietic cytokine induced by interleukin-17 in responsive cells.","types":["cytokine"],"aliases":["G-CSF"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_0dc4e92382f0c86edaac8c0980393ea9"},{"public_id":"co_0f2c5388f4612be805d163a38167b4d9","status":"active","name":"murine interleukin-17","description":"The mouse counterpart of interleukin-17 used for comparison with the human protein.","types":["cytokine"],"aliases":["murine IL-17"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_0f2c5388f4612be805d163a38167b4d9"},{"public_id":"co_1409d75b44d026faa781d48a25c384ba","status":"active","name":"activated memory CD4+ T cells","description":"Activated T lymphocytes of the memory CD4+ subset that secrete human interleukin-17.","types":["cell type"],"aliases":["activated memory CD4 positive T cells"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_1409d75b44d026faa781d48a25c384ba"},{"public_id":"co_1ecd624cd1d694a5115ab89bdaec555c","status":"active","name":"neutrophils","description":"A granulocyte lineage toward which hematopoietic progenitors preferentially mature in the described culture conditions.","types":["cell type"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_1ecd624cd1d694a5115ab89bdaec555c"},{"public_id":"co_31455319f04146e8625ed23f28dfab2a","status":"active","name":"T cell-dependent inflammatory reaction","description":"An inflammatory response initiated or supported by T cells.","types":["immune process"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_31455319f04146e8625ed23f28dfab2a"},{"public_id":"co_4958dc525a7c84711e2bf1a62a51806f","status":"active","name":"epithelial, endothelial, and fibroblastic cells","description":"Non-hematopoietic stromal and barrier cell types that respond to interleukin-17 by producing mediators.","types":["cell type"],"aliases":["epithelial cells","endothelial cells","fibroblastic cells"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_4958dc525a7c84711e2bf1a62a51806f"},{"public_id":"co_55acd476827975a7a24f30b78824fcc0","status":"active","name":"Herpesvirus saimiri ORF13","description":"A viral open reading frame encoding a product related to interleukin-17.","types":["viral gene product"],"aliases":["ORF13"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_55acd476827975a7a24f30b78824fcc0"},{"public_id":"co_68882bc3c5e9f360297e0190561f4cd0","status":"active","name":"IL-6","description":"Interleukin-6, a cytokine induced by interleukin-17 in responsive cells.","types":["cytokine"],"aliases":["interleukin-6"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_68882bc3c5e9f360297e0190561f4cd0"},{"public_id":"co_8ae342dee08f501123b6eafb3993837a","status":"active","name":"hematopoiesis","description":"The process of blood cell formation.","types":["biological process"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_8ae342dee08f501123b6eafb3993837a"},{"public_id":"co_949fd521cfb1d87be636a7c74395fcf4","status":"active","name":"prostaglandin E2","description":"A lipid mediator produced by responsive cells after interleukin-17 stimulation.","types":["mediator"],"aliases":["PGE2"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_949fd521cfb1d87be636a7c74395fcf4"},{"public_id":"co_94f460cf235fd4553def0bd2da5eb633","status":"active","name":"fibroblasts","description":"Connective tissue cells that, in culture, support hematopoietic progenitor proliferation in the presence of interleukin-17.","types":["cell type"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_94f460cf235fd4553def0bd2da5eb633"},{"public_id":"co_a2a1f6c60d47b6b208053ee6552106d2","status":"active","name":"hematopoietic cells","description":"Cells of blood-forming lineages used here to assess direct effects of interleukin-17.","types":["cell type"],"aliases":["cells of hematopoietic origin"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_a2a1f6c60d47b6b208053ee6552106d2"},{"public_id":"co_a8aad3f3ba705398d29ac45c87b208bb","status":"active","name":"CD34+ hematopoietic progenitors","description":"Early blood-forming progenitor cells marked by CD34 expression.","types":["progenitor cell"],"aliases":["CD34 positive hematopoietic progenitors"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_a8aad3f3ba705398d29ac45c87b208bb"},{"public_id":"co_bc97ef29f0c86123d2fee2ccc0835b8b","status":"active","name":"IL-8","description":"Interleukin-8, a cytokine induced by interleukin-17 in responsive cells.","types":["cytokine"],"aliases":["interleukin-8"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_bc97ef29f0c86123d2fee2ccc0835b8b"},{"public_id":"co_fbf73e018107aabe9c530e264f32ef5f","status":"active","name":"human interleukin-17","description":"A human cytokine corresponding to murine interleukin-17 and secreted by activated memory CD4+ T cells.","types":["cytokine"],"aliases":["hIL-17","IL-17","interleukin 17"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_fbf73e018107aabe9c530e264f32ef5f"}],"external_ids":{"DOI":"10.1084/JEM.183.6.2593","ArXiv":null,"PubMed":8676080,"PubMedCentral":"2192621","MAG":2158854771,"DBLP":null,"ACL":null},"open_access":{"is_open_access":true,"pdf_url":"https://rupress.org/jem/article-pdf/183/6/2593/1108210/2593.pdf","landing_url":"https://www.semanticscholar.org/paper/c70fdf1eefc80a1190de34b31e0268aed98b3356","source":"semantic_scholar","pdf_url_source":"semantic_scholar_open_access_pdf","license":"CCBYNCSA","status":"BRONZE","reason":null},"reference_availability":{"status":"available","references_indexed":true,"full_text_available":false,"full_text_source":null,"count_basis":"semantic_scholar_metadata","extraction_status":"not_applicable","reason":null},"source":{"provider":"episteme2","base_corpus":"semantic_scholar_dump","freshness_mode":"unknown","basis":["semantic_scholar_metadata","postgres_metadata"],"limits":["paper metadata is based on indexed upstream scholarly datasets","claims and concepts are available only for extracted papers","absence of claims or concepts means no extracted graph data is available in this response"],"status":"available","degraded":false,"degraded_reasons":[],"diagnostics":{"status":"available","degraded":false,"degraded_reasons":[],"metadata_status":"available","graph_status":"available","abstract_status":"available"},"source_flags":5},"paper_id":637142,"paper_uid":"21bc97bb-b144-485a-9da1-7af8b404f610","canonical_identity":{"paper_id":637142,"paper_uid":"21bc97bb-b144-485a-9da1-7af8b404f610","identity_status":"available","lookup_basis":"semantic_scholar_external_id","compatibility_path":"corpus_id"},"url":"https://sah.borca.ai/papers/765530"}