{"corpus_id":79039255,"paper_sha":"3667ab5ef37d341d2982dd52a3b7faed0a418325","doi":"10.1016/S0254-6272(17)30021-3","arxiv_id":null,"pmid":null,"pmcid":null,"mag_id":2600408549,"dblp_id":null,"acl_id":null,"title":"Sini decoction as an adjuvant therapy for angina pectoris: a systematic review of randomized controlled trials.","year":2017,"publication_date":"2017-02-15","venue":"","journal":{"name":"Journal of Traditional Chinese Medicine","pages":"12-22","volume":"37"},"journal_issn":null,"journal_title":null,"publication_types":["Review"],"pubmed_pub_types":null,"s2_fields_of_study":["Medicine"],"reference_count":34,"citation_count":3,"influential_citation_count":0,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":null,"chemicals":null,"comments_corrections":null,"source_flags":1,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"Abstract OBJECTIVE To systematically assess the effects and safety of Sini decoction as an adjuvant therapy for patients with angina pectoris. METHODS We searched PubMed, Excerpt Medica Database, the Cochrane library, Wanfang Database, China National Knowledge Infrastructure Database, China Science and Technology Journal Database from the date of its inception until August 1, in 2014. Available literatures were selected according to the inclusion criteria. Two reviewers finished data extraction, checked the data and assessed the methodological quality of studies, independently. The Review Manage Software 5.1.0 was used for data analysis. RESULTS Six trials involving 453 participants were eligible. None of the trials reported the mortality due to angina pectoris. The secondary outcomes showed that Sini decoction, together with nitroglycerin when necessary, may have some effects on reducing the number of angina attacks and the amount of nitroglycerin. But in terms of reducing the duration of angina and improvement of electrocardiogram, there were no statistical differences between Sini decoction group and isosorbide dinitrate group. Only one reported that no adverse events were found. CONCLUSION Based on this systematic review, Sini decoction can reduce the dosage of nitroglycerin, when compared with isosorbide dinitrate group. And there were no enough evidence in the papers to draw any conclusions for the safety of Sini decoction.","claims":[{"public_id":"cl_d577cfb2179c1ffff4773b182b7ac3cb","status":"active","text":"None of the six included trials reported mortality due to angina pectoris.","confidence":0.95,"contributors":[{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["extraction"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"},{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["review"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/claims/cl_d577cfb2179c1ffff4773b182b7ac3cb"},{"public_id":"cl_e78bb63e1a2fc7e25281ca4c85bad5cc","status":"active","text":"Only one trial reported no adverse events, and the review concluded there was insufficient evidence on the safety of Sini decoction.","confidence":0.9,"contributors":[{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["extraction"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"},{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["review"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/claims/cl_e78bb63e1a2fc7e25281ca4c85bad5cc"},{"public_id":"cl_022740a6a5d5dfc323d5549c13820f51","status":"active","text":"Sini decoction as an adjuvant therapy may reduce the number of angina attacks and the amount of nitroglycerin needed, but no statistical difference was found in reducing angina duration or improving electrocardiogram compared to isosorbide dinitrate.","confidence":0.85,"contributors":[{"id":2,"public_id":"4715169a40","public_label":"AK (4715169a40)","roles":["extraction"],"url":"https://sah.borca.ai/u/4715169a40"},{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["review"],"url":"https://sah.borca.ai/u/12632b8b5f"},{"id":32,"public_id":"7c402c1b98","public_label":"뀨 (7c402c1b98)","roles":["review"],"url":"https://sah.borca.ai/u/7c402c1b98"},{"id":1165,"public_id":"ezd9qvkvax","public_label":"The Reverser‮ (ezd9qvkvax)","roles":["review"],"url":"https://sah.borca.ai/u/ezd9qvkvax"}],"url":"https://sah.borca.ai/claims/cl_022740a6a5d5dfc323d5549c13820f51"}],"concepts":[{"public_id":"co_09f57b3d81579cf3a075e5731f43f610","status":"active","name":"electrocardiogram","description":"A diagnostic test for cardiac ischemia; improvement on electrocardiogram showed no statistical difference between 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