{"corpus_id":7980674,"paper_sha":"d6624c03a1aa5f4c06d223b7a62d20195c7304a8","doi":"10.1146/ANNUREV.ARPLANT.53.100301.135248","arxiv_id":null,"pmid":12221977,"pmcid":null,"mag_id":2096719701,"dblp_id":null,"acl_id":null,"title":"The lipoxygenase pathway.","year":2003,"publication_date":"2003-11-28","venue":"Annual Review of Plant Biology","journal":{"name":"Annual review of plant biology","pages":"\n          275-97\n        ","volume":"53"},"journal_issn":null,"journal_title":null,"publication_types":["Review","JournalArticle"],"pubmed_pub_types":["Journal Article","Review"],"s2_fields_of_study":["Biology","Medicine","Chemistry","Environmental Science"],"reference_count":131,"citation_count":1447,"influential_citation_count":97,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Lipoxygenase","mj":false,"qs":[{"q":"metabolism","mj":true,"ui":"Q000378"}],"ui":"D008084"},{"d":"Plants","mj":false,"qs":[{"q":"enzymology","mj":true,"ui":"Q000201"},{"q":"metabolism","mj":false,"ui":"Q000378"}],"ui":"D010944"}],"chemicals":[{"n":"Lipoxygenase","ui":"D008084","reg":"EC 1.13.11.12"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"▪ Abstract Lipid peroxidation is common to all biological systems, both appearing in developmentally and environmentally regulated processes of plants. The hydroperoxy polyunsaturated fatty acids, synthesized by the action of various highly specialized forms of lipoxygenases, are substrates of at least seven different enzyme families. Signaling compounds such as jasmonates, antimicrobial and antifungal compounds such as leaf aldehydes or divinyl ethers, and a plant-specific blend of volatiles including leaf alcohols are among the numerous products. Cloning of many lipoxygenases and other key enzymes within the lipoxygenase pathway, as well as analyses by reverse genetic and metabolic profiling, revealed new reactions and the first hints of enzyme mechanisms, multiple functions, and regulation. These aspects are reviewed with respect to activation of this pathway as an initial step in the interaction of plants with pathogens, insects, or abiotic stress and at distinct stages of development.","claims":[{"public_id":"cl_86716c9a73908f5a6a59304375306304","status":"active","text":"Activation of the lipoxygenase pathway is associated with plant interactions with pathogens, insects, and abiotic stress, as well as with distinct stages of development.","confidence":0.91,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_86716c9a73908f5a6a59304375306304"},{"public_id":"cl_a03a476d8abfa3f4bc35f10c6ee91a63","status":"active","text":"Cloning of lipoxygenases and related enzymes, together with reverse genetics and metabolic profiling, revealed new reactions and initial evidence for enzyme mechanisms, multiple functions, and regulation in the lipoxygenase pathway.","confidence":0.93,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_a03a476d8abfa3f4bc35f10c6ee91a63"},{"public_id":"cl_14786dfbe19f5522e3f8d9a8168547eb","status":"active","text":"Hydroperoxy polyunsaturated fatty acids produced by specialized lipoxygenases serve as substrates for at least seven enzyme families.","confidence":0.98,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_14786dfbe19f5522e3f8d9a8168547eb"},{"public_id":"cl_4f3501595456da5fa752251a0606579a","status":"active","text":"Jasmonates, leaf aldehydes, divinyl ethers, and plant-specific volatile blends including leaf alcohols are products of the lipoxygenase pathway.","confidence":0.95,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_4f3501595456da5fa752251a0606579a"}],"concepts":[{"public_id":"co_036da21379afa5096d33c6f4da8156e3","status":"active","name":"divinyl ethers","description":"Oxygenated lipid-derived compounds formed in the lipoxygenase pathway.","types":["metabolite","defense compound"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_036da21379afa5096d33c6f4da8156e3"},{"public_id":"co_06ee86ac0440c5eac8f7a9b5afacf6f0","status":"active","name":"hydroperoxy polyunsaturated fatty acids","description":"Oxidized polyunsaturated fatty acids that act as key intermediates in the 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