{"corpus_id":806402,"paper_sha":"3a1f43944ce25f9669f9d9621e32583d11b3e80a","doi":"10.1016/s0022-3565(25)26415-1","arxiv_id":null,"pmid":14020934,"pmcid":null,"mag_id":1949839345,"dblp_id":null,"acl_id":null,"title":"The peripheral actions of oxotremorine, a metabolite of tremorine.","year":1962,"publication_date":"1962-11-01","venue":"Journal of Pharmacology and Experimental Therapeutics","journal":{"name":"The Journal of pharmacology and experimental therapeutics","pages":"\n          249-57\n        ","volume":"138"},"journal_issn":null,"journal_title":null,"publication_types":["JournalArticle"],"pubmed_pub_types":["Journal Article"],"s2_fields_of_study":["Medicine","Chemistry"],"reference_count":0,"citation_count":141,"influential_citation_count":1,"is_open_access":false,"arxiv_categories":null,"arxiv_license":null,"arxiv_journal_ref":null,"mesh_headings":[{"d":"Blood Pressure","mj":true,"ui":"D001794"},{"d":"Oxotremorine","mj":true,"ui":"D010095"},{"d":"Parasympathomimetics","mj":true,"ui":"D010277"},{"d":"Pyrroles","mj":true,"ui":"D011758"},{"d":"Tremorine","mj":true,"ui":"D014203"}],"chemicals":[{"n":"Parasympathomimetics","ui":"D010277","reg":"0"},{"n":"Pyrroles","ui":"D011758","reg":"0"},{"n":"Oxotremorine","ui":"D010095","reg":"5RY0UWH1JL"},{"n":"Tremorine","ui":"D014203","reg":"U817VZ1URQ"}],"comments_corrections":null,"source_flags":5,"s2_open_access_pdf_url":null,"s2_open_access_landing_url":null,"s2_open_access_license":null,"s2_open_access_status":null,"pmc_open_access_pdf_url":null,"pmc_open_access_landing_url":null,"pmc_open_access_license":null,"pmc_open_access_status":null,"unpaywall_open_access_pdf_url":null,"unpaywall_open_access_landing_url":null,"unpaywall_open_access_license":null,"unpaywall_open_access_status":null,"abstract":"The peripheral pharmacology of oxotremorine [1(2-oxopyrrolidino)-4-pyrrolidino-butyne-2], a metabolite of tremorine, has been described. This compound is a muscarinic agent equal in potency to acetylcholine, but completely lacking in nicotinic activity. It has been shown to exert its effects solely by stimulation of the postganglionic cholinergic receptors.\n\nStructure-activity relationships of oxotremorine and other muscarinic agents have been discussed.","claims":[{"public_id":"cl_a097463bacef9d11081c1a2f8663e705","status":"active","text":"Its peripheral effects are mediated solely by stimulation of postganglionic cholinergic receptors.","confidence":0.96,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_a097463bacef9d11081c1a2f8663e705"},{"public_id":"cl_3c9b7c89f999f3ad286ec3e6aeda6410","status":"active","text":"Oxotremorine is a muscarinic agent with potency equal to acetylcholine but with no nicotinic activity.","confidence":0.98,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_3c9b7c89f999f3ad286ec3e6aeda6410"},{"public_id":"cl_933a6ee66b83d85fd0322b8b5168a744","status":"active","text":"Structure-activity relationships of oxotremorine and other muscarinic agents are discussed.","confidence":0.78,"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/claims/cl_933a6ee66b83d85fd0322b8b5168a744"}],"concepts":[{"public_id":"co_0b0fa770fa77efee35318d2e48608c41","status":"active","name":"nicotinic activity","description":"Pharmacological activity at nicotinic cholinergic receptors.","types":["pharmacological activity"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous 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tremorine.","types":["compound","metabolite"],"aliases":["1(2-oxopyrrolidino)-4-pyrrolidino-butyne-2"],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_560603d162a29b9075a4461975ee6771"},{"public_id":"co_72381e35519eac4eee9f7b74df2a9c89","status":"active","name":"peripheral pharmacology","description":"The study of drug actions in the body's peripheral tissues and organs.","types":["field"],"aliases":[],"contributors":[{"id":1,"public_id":"12632b8b5f","public_label":"Anonymous (12632b8b5f)","roles":["extraction"],"url":"https://sah.borca.ai/u/12632b8b5f"}],"url":"https://sah.borca.ai/concepts/co_72381e35519eac4eee9f7b74df2a9c89"},{"public_id":"co_a190f105a9e635d8cc93f90256fefb06","status":"active","name":"acetylcholine","description":"An endogenous neurotransmitter used here as a potency comparator.","types":["neurotransmitter","reference 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